Effects of Phytosterol Ester-Enriched Vegetable Oil on Serum Cholesterol and Assessment of Safety in Healthy Men
スポンサーリンク
概要
- 論文の詳細を見る
The purpose of this study was to determine the effects of phytosterol ester-enriched vegetable oil on the serum concentration of cholesterol and to assess its safety in healthy subjects with normocholesterolemics. Twenty-two healthy subjects completed this study in a double blind, parallel arm design. The subjects were randomly divided into 2 groups: control group (n = 11) and phytosterol ester-enriched group (n = 11), and fed either 42 g of phytosterol ester-enriched vegetable oil or control vegetable oil, containing about 1.336 g and 0.117 g of phytosterol (as the major free sterol) respectively, daily for 4 weeks. Serum lipids, apolipoproteins, serum fat-soluble vitamins, serum phytosterols and biochemical parameters were measured. The subjects were asked to report any side effect. Phytosterol ester-enriched vegetable oil significantly reduced the concentrations of serum total cholesterol, low-density lipoprotein cholesterol and apolipoprotein B, by 3.3%, 4.4% and 3.2% respectively, compared with control oil. No significant changes were found in the concentrations of triacylglycerol, high-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, remnant-like lipoprotein cholesterol and other kinds of apolipoproteins. Neither vegetable oil affected the concentrations of fat-soluble vitamins (retinol and α-tocopherol) or β-carotene. Serum β-sitosterol and campesterol were significantly higher in the phytosterol ester-enriched vegetable oil group compared with the control oil group. The concentrations of biochemical parameters did not change in either group. There were no side effects or serious adverse events in either group during the administration. In conclusion, the results showed that a daily 1.336 g intake of phytosterol (as the major free sterol) is effective in lowering serum total- and LDL-cholesterol in healthy men and has no negative physiologic action.
- 日本油化学会の論文
- 2003-04-01
著者
-
Hidaka Ichirou
日清オイリオ研究所
-
Hidaka Ichirou
Division Of Healthcare Science Research Laboratory The Nisshin Oillio Ltd.
-
KONDO Kazuo
Institute of Environmental Science for Human Life, Ochanomizu University
-
Kondo Kazuo
長野県工業技術総合センター 食品技術部門加工食品部
-
Kondo Kazuo
Institute Of Environmental Science For Human Life Ochanomizu University
-
SEKI Shinji
Division of Healthcare Science Research Laboratory, The Nisshin OilliO, Ltd.
-
ABE Tatsuichirou
Division of Healthcare Science Research Laboratory, The Nisshin OilliO, Ltd.
-
KOJIMA Keiichi
Division of Healthcare Science Research Laboratory, The Nisshin OilliO, Ltd.
-
YOSHINO Hisako
Division of Healthcare Science Research Laboratory, The Nisshin OilliO, Ltd.
-
AOYAMA Toshiaki
Division of Healthcare Science Research Laboratory, The Nisshin OilliO, Ltd.
-
OKAZAKI Mitsuko
Kagawa Nutrition University
-
Aoyama Toshiaki
Novelty Materials Research Institute Hannan R&d Center Fuji Oil Co.ltd.
-
Aoyama Toshiaki
Division Of Healthcare Science Central Research Laboratory The Nisshin Oillio Group Ltd.
-
Seki Shinji
Division Of Healthcare Science Research Laboratory The Nisshin Oillio Ltd.
-
Kojima Keiichi
Division Of Healthcare Science Central Research Laboratory The Nisshin Oillio Group Ltd.
-
Yoshino Hisako
Division Of Healthcare Science Research Laboratory The Nisshin Oillio Ltd.
-
Kondo K
Institute Of Environmental Science For Human Life Ochanomizu University
-
Okazaki M
Kagawa Nutrition Univ.
-
Abe Tatsuichirou
Division Of Healthcare Science Research Laboratory The Nisshin Oillio Ltd.
-
Aoyama Toshiaki
Central Res. Lab. The Nisshin Oillio Group Ltd.
関連論文
- Effect of Life-Long Dietary n-6/n-3 Fatty Acid Ratio on Life Span, Serum Lipids and Serum Glucose in Wistar Rats
- Inhibition of Low-Density Lipoprotein Oxidation by Nagano Purple Grape (Vitis vinifera×Vitis labrusca)
- Suppressive Effect of Cocoa Powder on Atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic Rabbits
- Antioxidant Ability of Various Flavonoids against DPPH Radicals and LDL Oxidation
- Lipoprotein Analysis Using Agarose Gel Electrophoresis and Differential Staining of Lipids
- Inhibition of Low-Density Lipoprotein Oxidation by Astaxanthin
- Regulation of Hepatic High Density Lipoprotein Binding Protein, HB_2, Expression after Administration of Simvastatin to Rabbits
- Effects of Cacao Liquor Polyphenols on the Susceptibility of Low-density Lipoprotein to Oxidation in Hypercholesterolemic Rabbits
- Antioxidant Effects of Polyphenols in Chocolate on Low-Density Lipoprotein both In Vitro and Ex Vivo
- Antioxidative Effects of Choi-joki-to and its Ability to Inhibit the Progression of Atheroma in KHC Rabbits
- A Candidate High Density Lipoprotein (HDL) Receptor, HB_2, with Possible Multiple Functions Shows Sequence Homology with Adhesion Molecules
- Analysis of (-)-Epigallocatechin Gallate in Human Serum Obtained after Ingesting Green Tea
- Vegetable Oil Enriched with Phytosterol Ester and the Degree of Serum Cholesterol Lowering Effect in Healthy Subjects
- Effects of Phytosterol Esters on Serum Lipids and Fecal Steroids Excretion in Hamsters
- Effects of Phytosterol Ester-Enriched Vegetable Oil on Serum Cholesterol and Assessment of Safety in Healthy Men
- Dose-Response Study of Daily Cocoa Intake on the Oxidative Susceptibility of Low-Density Lipoprotein in Healthy Human Volunteers
- Preparation of a Lemon Flavonoid Aglycone and its Suppressive Effect on the Susceptibility of LDL to Oxidation Following Human Ingestion
- Difference in Plasma Metabolite Concentration after Ingestion of Lemon Flavonoids and Their Aglycones in Humans
- PJ-719 Purified small dense LDL particle enhanced lipid accumulation and foam cell formation in THP-1 macrophage(Lipid disorders(04)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Combined Intervention of Medium-Chain Triacylglycerol Diet and Exercise Reduces Body Fat Mass and Enhances Energy Expenditure in Rats
- Dietary Medium- and Long-chain Triacylglycerols Accelerate Diet-Induced Thermogenesis in Humans
- Randomly Interesterified Triacylglycerol Containing Medium- and Long-Chain Fatty Acids Stimulates Fatty Acid Metabolism in White Adipose Tissue of Rats
- Effect of Randomly Interesterified Triacylglycerols Containing Medium- and Long-Chain Fatty Acids on Energy Expenditure and Hepatic Fatty Acid Metabolism in Rats
- Effects of Ingestion of Margarine Containing Medium-Chain Triglycerides for 4 Weeks on Blood Parameters and Postprandial Thermogenesis
- Effects of Margarine Containing Medium-chain Triacylglycerols on Body Fat Reduction in Humans
- Effect of Medium-Chain Triglycerides on Postprandial Concentrations of Remnant-Like Particles in Healthy Men
- Effect of Medium-chain Triglycerides on the Postprandial Triglyceride Concentration in Healthy Men(Food & Nutrition Science)
- Comparison of Diet-Induced Thermogenesis of Foods Containing Medium- versus Long-Chain Triacylglycerols
- Effects of Dietary Medium-Chain Triacylglycerols on Serum Lipoproteins and Biochemical Parameters in Healthy Men(Food & Nutrition Sience)
- Decrease of Food Intake in Rats after Ingestion of Medium-Chain Triacylglycerol
- The Coantioxidative Effects of Carboxyethyl-6-Hydroxychromans and α-Tocopherol
- γ-Tocopherol Enhances Sodium Excretion as a Natriuretic Hormone Precursor
- Wine Has Activity against Entero-pathogenic Bacteria in Vitro but not in Vivo
- Reduction by Phytate-reduced Soybean β-Conglycinin of Plasma Triglyceride Level of Young and Adult Rats
- Effect of Soy and Milk Whey Protein Isolates and Their Hydrolysates on Weight Reduction in Genetically Obese Mice
- Physiological Effects of Water-soluble Soybean Fiber in Rats
- Effects of Equol on Oxidized Low-Density Lipoprotein-Induced Apoptosis in Endothelial Cells
- Contribution of Rho A and Rho Kinase to Platelet-Derived Growth Factor-BB-Induced Proliferation of Vascular Smooth Muscle Cells
- PJ-221 Sphingosine 1-phosphate (S1P) Inhibits Monocyte Adhesion via Modulation of RhoA Activity under Atherosclerosis-prone Condition(Atherosclerosis, basic-9, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Effects of Margarine Containing Medium-Chain Triglycerides on Diet-Induced Thermogenesis
- Larger Diet-Induced Thermogenesis and Less Body Fat Accumulation in Rats Fed Medium-Chain Triacylglycerols than in Those Fed Long-Chain Triacylglycerols
- Nutritional Effects of Randomly Interesterified and Physically Mixed Oils Containing Medium-chain Fatty Acids on Rats
- Effect of Medium-Chain Fatty Acids-Containing Dietary Oil on Hepatic Fatty Acid Oxidation Enzyme Activity in Rats
- Effects of Antioxidants on the Oxidative Susceptibility of Low-Density Lipoprotein
- The Polyphenol Content and Antioxidant Activities of the Main Edible Vegetables in Northern Vietnam
- Total Synthesis of (+)-Paulownin
- Total Synthesis of (+)-Phrymarolin I from (+)-Malic Acid
- Inhibitory Effects of Balsamic Vinegar on LDL Oxidation and Lipid Accumulation in THP-1 Macrophages
- Improved Procedure for the Enantiometric Synthesis of 1-Hydroxy/acetoxy-2,6-diaryl-3,7-dioxabicyclo [3 .3. 0] octane Lignans : Total Syntheses of (+)-Paulownin, (+)-Phrymarin I and (+)-Phrymarin II
- Effect of Dietary n-6/n-3 Ratio on Liver n-6/n-3 Ratio and Peroxisomal β-Oxidation Activity in Rats
- Effect of Randomly Interesterified Triacylglycerol Containing Medium- and Long-Chain Fatty Acids on Hepatic Fatty Acid Oxidation after a Single Administration to Rats
- Chinese Hypertriglycerideamic Subjects of Different Ages Responded Differently to Consuming Oil with Medium- and Long-Chain Fatty Acids
- Systematic Strategy for the Synthesis of Cyanobacterin and Its Stereoisomers. 2. Asymmetric Total Synthesis of the 2- and 3-Epimers of Dechloro-cyanobacterin(Organic Chemistry)
- Systematic Strategy for the Synthesis of Cyanobacterin and Its Stereoisomers. 1. Asymmetric Total Synthesis of Dechloro-cyanobacterin and Its Enantiomer(Organic Chemistry)
- Dietary Alpha-Linolenic Acid Inhibits Angiotensin-Converting Enzyme Activity and mRNA Expression Levels in the Aorta of Spontaneously Hypertensive Rats
- Effect of Dietary Alpha-Linolenic Acid on Vascular Reactivity in Aorta of Spontaneously Hypertensive Rats
- Separation and recovery of precious and base metals using a column packed with microcapsules containing an extractant
- Extraction of Precious and Base Metals with Microcapsules Containing an Extractant
- Lowering Systolic Blood Pressure and Increases in Vasodilator Levels in SHR with Oral α-Linolenic Acid Administration
- Safety of Dietary Conjugated Linoleic Acid (CLA) in a 12-weeks Trial in Healthy Overweight Japanese Male Volunteers
- Mechanism of Synergistic Extraction of Samarium Using Alkylphosphoric Acid as Main Extractant
- Effect of Dietary Lard Containing Higher α-Linolenic Acid on Plasma Triacylglycerol in Rats
- Effects of Antioxidants on the Oxidative Susceptibility of Low-Density Lipoprotein
- Comparison of Diet-Induced Thermogenesis of Foods Containing Medium- versus Long-Chain Triacylglycerols
- Efficacy of γ-linolenic Acid for Treatment of Premenstrual Syndrome, as Assessed by a Prospective Daily Rating System
- Dietary Supplementation of Gamma-Linolenic Acid Improves Skin Parameters in Subjects with Dry Skin and Mild Atopic Dermatitis
- Astaxanthin Enhances ATP-Binding Cassette Transporter A1/G1 Expressions and Cholesterol Efflux from Macrophages
- The Change in Conjugated Linoleic Acid Concentration in Blood of Japanese Fed a Conjugated Linoleic Acid Diet
- Antioxidant Activities of Perilla frutescens against Low-Density Lipoprotein Oxidation in Vitro and in Human Subjects
- Preliminary Research for the Anti-obesity Effect of Puerariae Flos Extract in Humans
- Consumption of Pueraria Flower Extract Reduces Body Mass Index via a Decrease in the Visceral Fat Area in Obese Humans
- Medium-Chain Triacylglycerol Suppresses the Decrease of Plasma Albumin Level through the Insulin-Akt-mTOR Pathway in the Livers of Malnourished Rats
- Position-scanning spectrophotometer as a means of observing multicomponent diffusion phenomena in liquid phase.