Lowering Systolic Blood Pressure and Increases in Vasodilator Levels in SHR with Oral α-Linolenic Acid Administration
スポンサーリンク
概要
- 論文の詳細を見る
The present study attempted to clarify the antihypertensive effect and its mechanism when α-linolenic acid (ALA) is administered orally. For this purpose, 1 mL of flaxseed oil, which is rich in ALA, and high oleic safflower oil was administered orally to spontaneously hypertensive rats (SHR) of a control and an ALA group on days 1 and 5. Systolic blood pressure was measured on day 1, and blood and liver were collected on day 5. Four hours after the oral administration on day 1, systolic blood pressure of the ALA group was lower than that of the control group. Levels of plasma vasodilators, such as prostaglandin I2 metabolite, nitric oxide metabolites, and bradykinin, in the ALA group were significantly higher than those in the control group, but levels of vasoconstrictors, such as angiotensin II and thromboxane A2 metabolite, did not differ significantly. It is known that bradykinin induces prostaglandin I2 and nitric oxide. The present study shows that ALA reduced the systolic blood pressure of SHR, and its mechanism may be related to increases of prostaglandin I2 and nitric oxide through bradykinin stimulation.
- 日本油化学会の論文
著者
-
Sekine Seiji
Central Research Laboratory The Nisshin Oillio Group
-
Aoyama Toshiaki
Novelty Materials Research Institute Hannan R&d Center Fuji Oil Co.ltd.
-
Aoyama Toshiaki
Central Research Laboratory The Nisshin Oillio Group
-
Takeuchi Hiroyuki
Central Research Laboratory Of The Nisshin Oillio Group Ltd.
-
Sasanuki Shiho
Central Research Laboratory, The Nisshin Oillio Group, Ltd.
-
Aoyama Toshiaki
Central Research Laboratory Nisshin Oillio Group
-
Aoyama Toshiaki
Central Res. Lab. The Nisshin Oillio Group Ltd.
-
Sekine Seiji
Central Research Laboratory of The Nisshin OilliO Group, LTD.
関連論文
- Effect of Life-Long Dietary n-6/n-3 Fatty Acid Ratio on Life Span, Serum Lipids and Serum Glucose in Wistar Rats
- Characterization of glutamate decarboxylase mediating γ-amino butyric acid increase in the early germination stage of soybean (Glycine max [L.] Merr)(PLANT BIOTECHNOLOGY)
- Vegetable Oil Enriched with Phytosterol Ester and the Degree of Serum Cholesterol Lowering Effect in Healthy Subjects
- Effects of Phytosterol Esters on Serum Lipids and Fecal Steroids Excretion in Hamsters
- Effects of Phytosterol Ester-Enriched Vegetable Oil on Serum Cholesterol and Assessment of Safety in Healthy Men
- Combined Intervention of Medium-Chain Triacylglycerol Diet and Exercise Reduces Body Fat Mass and Enhances Energy Expenditure in Rats
- Randomly Interesterified Triacylglycerol Containing Medium- and Long-Chain Fatty Acids Stimulates Fatty Acid Metabolism in White Adipose Tissue of Rats
- Effect of Randomly Interesterified Triacylglycerols Containing Medium- and Long-Chain Fatty Acids on Energy Expenditure and Hepatic Fatty Acid Metabolism in Rats
- Effects of Ingestion of Margarine Containing Medium-Chain Triglycerides for 4 Weeks on Blood Parameters and Postprandial Thermogenesis
- Effects of Margarine Containing Medium-chain Triacylglycerols on Body Fat Reduction in Humans
- Effect of Medium-Chain Triglycerides on Postprandial Concentrations of Remnant-Like Particles in Healthy Men
- Effect of Medium-chain Triglycerides on the Postprandial Triglyceride Concentration in Healthy Men(Food & Nutrition Science)
- Comparison of Diet-Induced Thermogenesis of Foods Containing Medium- versus Long-Chain Triacylglycerols
- Effects of Dietary Medium-Chain Triacylglycerols on Serum Lipoproteins and Biochemical Parameters in Healthy Men(Food & Nutrition Sience)
- Decrease of Food Intake in Rats after Ingestion of Medium-Chain Triacylglycerol
- Reduction by Phytate-reduced Soybean β-Conglycinin of Plasma Triglyceride Level of Young and Adult Rats
- Effect of Soy and Milk Whey Protein Isolates and Their Hydrolysates on Weight Reduction in Genetically Obese Mice
- Physiological Effects of Water-soluble Soybean Fiber in Rats
- Larger Diet-Induced Thermogenesis and Less Body Fat Accumulation in Rats Fed Medium-Chain Triacylglycerols than in Those Fed Long-Chain Triacylglycerols
- Nutritional Effects of Randomly Interesterified and Physically Mixed Oils Containing Medium-chain Fatty Acids on Rats
- Effect of Medium-Chain Fatty Acids-Containing Dietary Oil on Hepatic Fatty Acid Oxidation Enzyme Activity in Rats
- Improvement in Storage Stability of Pork Fat Using Dietary Soybean Phospholipids
- Improvement in Storage Stability of Fish Fillets Using Dietary Soybean Phosphatidylcholine and Phosphatidylethanolamine
- Improvement in Storage Stability of Fish Fillet Using Dietary Soybean Phospholipids
- Effect of Dietary n-6/n-3 Ratio on Liver n-6/n-3 Ratio and Peroxisomal β-Oxidation Activity in Rats
- Effect of Randomly Interesterified Triacylglycerol Containing Medium- and Long-Chain Fatty Acids on Hepatic Fatty Acid Oxidation after a Single Administration to Rats
- Chinese Hypertriglycerideamic Subjects of Different Ages Responded Differently to Consuming Oil with Medium- and Long-Chain Fatty Acids
- Compensatory Expression of MRP3 in the Livers of MRP2-Deficient EHBRs Is Promoted by DHA Intake
- Dietary Alpha-Linolenic Acid Inhibits Angiotensin-Converting Enzyme Activity and mRNA Expression Levels in the Aorta of Spontaneously Hypertensive Rats
- Effect of Dietary Alpha-Linolenic Acid on Vascular Reactivity in Aorta of Spontaneously Hypertensive Rats
- Lowering Systolic Blood Pressure and Increases in Vasodilator Levels in SHR with Oral α-Linolenic Acid Administration
- Effect of Dietary Lard Containing Higher α-Linolenic Acid on Plasma Triacylglycerol in Rats
- Comparison of Diet-Induced Thermogenesis of Foods Containing Medium- versus Long-Chain Triacylglycerols
- Dietary Supplementation of Gamma-Linolenic Acid Improves Skin Parameters in Subjects with Dry Skin and Mild Atopic Dermatitis
- The Change in Conjugated Linoleic Acid Concentration in Blood of Japanese Fed a Conjugated Linoleic Acid Diet
- Medium-Chain Triacylglycerol Suppresses the Decrease of Plasma Albumin Level through the Insulin-Akt-mTOR Pathway in the Livers of Malnourished Rats