Effect of Randomly Interesterified Triacylglycerols Containing Medium- and Long-Chain Fatty Acids on Energy Expenditure and Hepatic Fatty Acid Metabolism in Rats
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概要
- 論文の詳細を見る
In our previous studies, medium- and long-chain triacylglycerols (MLCT), randomly interesterified triacylglycerols containing medium-chain and long-chain fatty acids in the same glycerol molecule, significantly reduced body fat accumulation in humans and rats. To clarify mechanism(s) for this effect of MLCT, we measured energy expenditure and hepatic fatty acid metabolism in rats by comparison with long-chain triacylglycerols (LCT) or medium-chain triacylglycerols (MCT). MLCT, compared with LCT, showed significantly lower body fat accumulation, higher 24-h energy expenditure and acyl-CoA dehydrogenase activity measured using octanoyl-CoA as a substrate, and similar lipogenic activity. MCT, compared with LCT, showed significantly higher energy expenditure, but fat accumulation was comparable. Additionally, MCT exhibited significantly higher lipogenic activity than the other oils. These data suggest that enhancement of energy expenditure and medium-chain fatty acids (MCFA) oxidation without activating de novo lipogenesis are responsible at least for the lower body fat accumulation in rats fed MLCT. The activation of hepatic lipogenesis by excessive intake of MCFA might counteract their preventive effects on body fat accumulation.
- 社団法人 日本農芸化学会の論文
- 2005-10-23
著者
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KASAI Michio
The Nisshin OilliO Group, Ltd.
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AOYAMA Toshiaki
Division of Healthcare Science Research Laboratory, The Nisshin OilliO, Ltd.
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Kasai M
The Nisshin Oillio Group Ltd.
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Aoyama Toshiaki
Novelty Materials Research Institute Hannan R&d Center Fuji Oil Co.ltd.
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Aoyama Toshiaki
Division Of Healthcare Science Central Research Laboratory The Nisshin Oillio Group Ltd.
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Kasai Michio
The Nisshin Oillio Group Ltd.
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KASAI Michio
Division of Healthcare Science, Central Research Laboratory, The Nisshin OilliO Group, Ltd.
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SHINOHARA Hisami
Division of Healthcare Science, Research Laboratory, The Nisshin OilliO Group, Ltd.
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OGAWA Akiko
Division of Healthcare Science, Research Laboratory, The Nisshin OilliO Group, Ltd.
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SHINOHARA Hisami
Central Research Laboratory, The Nisshin OilliO Group, Ltd.
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Shinohara Hisami
Central Research Laboratory The Nisshin Oillio Group Ltd.
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Kasai Michio
Division Of Healthcare Science Research Laboratory The Nisshin Oillio Group Ltd.
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Aoyama Toshiaki
Central Res. Lab. The Nisshin Oillio Group Ltd.
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SHINOHARA Hisami
Division of Healthcare Science Research Laboratory, Nisshin Oil Mills, LTD.
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