Vegetable Oil Enriched with Phytosterol Ester and the Degree of Serum Cholesterol Lowering Effect in Healthy Subjects
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概要
- 論文の詳細を見る
Phytosterols are natural dietary components and their lowering effect on serum cholesterol level has been well documented. There have been few reports about the effect of less than 1g/day of phytosterol on serum cholesterol level. We attempted to investigate serum cholesterol lowering effect of phytosterol at 2 relatively low doses. In a randomized, double-blind, 3-group parallel protocol, 67 healthy men with a total cholesterol of 221.5 ± 17.0 (mean ± SD, mg/dL) consumed each about 0.04 g/day, 0.29 g/day and 0.45 g/day of phytosterol (as the major free sterol) for 4 weeks. The level of total cholesterol decreased by 1.0%, 0.5% and 7.9% in the control, the low-and the high-phytosterol group, respectively. As for LDL-cholesterol level, these decreases were 1.8%, 1.0% and 9.5%, respectively. The relative reduction rates of total-and LDL-cholesterol levels in the high-phytosterol group were significantly different from the others, whereas no difference between the control and the low-phytosterol group were observed. No significant difference in the levels of VLDL-cholesterol, HDL-cholesterol or triacylglycerol were found among the groups. Apolipoprotein B and RLP-cholesterol levels were also lower in the higher group. These results indicate that a daily intake of about 0.45 g phytosterol beneficially affect the levels of total- and LDL-cholesterol even in healthy subjects with a slightly elevated serum cholesterol level, and that it may be helpful in reducing the risk of CHD.
- 日本油化学会の論文
- 2003-06-01
著者
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Hidaka Ichirou
日清オイリオ研究所
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Hidaka Ichirou
Division Of Healthcare Science Research Laboratory The Nisshin Oillio Ltd.
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KONDO Kazuo
Institute of Environmental Science for Human Life, Ochanomizu University
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Kondo Kazuo
長野県工業技術総合センター 食品技術部門加工食品部
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Kondo Kazuo
Institute Of Environmental Science For Human Life Ochanomizu University
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SEKI Shinji
Division of Healthcare Science Research Laboratory, The Nisshin OilliO, Ltd.
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ABE Tatsuichirou
Division of Healthcare Science Research Laboratory, The Nisshin OilliO, Ltd.
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KOJIMA Keiichi
Division of Healthcare Science Research Laboratory, The Nisshin OilliO, Ltd.
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YOSHINO Hisako
Division of Healthcare Science Research Laboratory, The Nisshin OilliO, Ltd.
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AOYAMA Toshiaki
Division of Healthcare Science Research Laboratory, The Nisshin OilliO, Ltd.
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OKAZAKI Mitsuko
Kagawa Nutrition University
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Aoyama Toshiaki
Novelty Materials Research Institute Hannan R&d Center Fuji Oil Co.ltd.
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Aoyama Toshiaki
Division Of Healthcare Science Central Research Laboratory The Nisshin Oillio Group Ltd.
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Seki Shinji
Division Of Healthcare Science Research Laboratory The Nisshin Oillio Ltd.
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Kojima Keiichi
Division Of Healthcare Science Central Research Laboratory The Nisshin Oillio Group Ltd.
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Yoshino Hisako
Division Of Healthcare Science Research Laboratory The Nisshin Oillio Ltd.
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Kondo K
Institute Of Environmental Science For Human Life Ochanomizu University
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Okazaki M
Kagawa Nutrition Univ.
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Abe Tatsuichirou
Division Of Healthcare Science Research Laboratory The Nisshin Oillio Ltd.
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Aoyama Toshiaki
Central Res. Lab. The Nisshin Oillio Group Ltd.
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