Decrease of Food Intake in Rats after Ingestion of Medium-Chain Triacylglycerol

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概要

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• Previous studies have demonstrated that fatty acid oxidation in the liver may affect food intake. This study examined the influence of preloading of medium-chain triacylglycerol (MCT) on food intake in comparison with long-chain triacylglycerol (LCT). Male rats were fasted for 18 h and then administered LCT or MCT emulsion orally. Each group of rats was allowed to rest for 30 min, and then food intake during 1 h was measured. Food intake in the MCT group was significantly lower than that in the LCT group. To examine the influence of hepatic oxidation, the MCT+MA group was injected intraperitoneally with mercaptoacetate (MA), an inhibitor of fatty acid oxidation, 2 h before ingestion of MCT emulsion. Then, 30 min after ingestion of LCT or MCT emulsion, food intake was measured for 1 h. Food intake in the MCT group was significantly lower than that in the LCT group, but there was no significant difference between the MCT+MA group and the LCT group. Food intake in the MCT+MA group was significantly higher than that in the MCT group. The hepatic ATP content after MCT ingestion was significantly higher than that after LCT ingestion, but there was no significant difference between the MCT+MA group and the LCT group. The hepatic ATP content after MCT+MA ingestion was significantly lower than that after MCT ingestion. These results suggest that ingestion of medium-chain fatty acid (MCFA) increases the liver ATP content in fasted rats, consequently decreasing food intake.

• 2009-10-01

著者

• Kondo Kazuo

  長野県工業技術総合センター 食品技術部門加工食品部

• Kondo Kazuo

  Institute Of Environmental Science For Human Life Ochanomizu University

• Aoyama Toshiaki

  Novelty Materials Research Institute Hannan R&d Center Fuji Oil Co.ltd.

• Aoyama Toshiaki

  Division Of Healthcare Science Central Research Laboratory The Nisshin Oillio Group Ltd.

• Takeuchi Hisanao

  Department Of Applied Biochemical Chemistry Faculty Of Agriculture Shizuoka University

• OOYAMA Katsuhiko

  Division of Healthcare Science, Central Research Laboratory, The Nisshin OilliO Group, Ltd.

• Ooyama Katsuhiko

  Division Of Healthcare Science Central Research Laboratory The Nisshin Oillio Group Ltd.

• Kojima Keiichi

  Division Of Healthcare Science Central Research Laboratory The Nisshin Oillio Group Ltd.

• Kondo K

  Institute Of Environmental Science For Human Life Ochanomizu University

• Takeuchi Hiroyuki

  Division Of Healthcare Science Central Research Laboratory The Nisshin Oillio Group Ltd.

• Takeuchi Hiroyuki

  Division Of Food Science Research Laboratory Of Nisshin Oil Mills

• Aoyama Toshiaki

  Central Res. Lab. The Nisshin Oillio Group Ltd.

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