Hypoglycemic Effect of Water-soluble Polysaccharide from Auricularia auricula-judae Quel. on Genetically Diabetic KK-A^y Mice

概要

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The hypoglycemic effect of water-soluble polysaccharide (FA) from fruiting bodies of Auricularia auriculajudae Quel. was investigated on genetically diabetic mice (KK-A^y) from 10 to 14 weeks of age. Male mice were divided into 3 groups, the control group and FA-fed group having free access to the control diet or FA diet (30 g of FA/kg of diet). The food-restricted group had restricted access to the control diet at the level of the diet consumed by the FA-fed group. Compared with the control group, FA supplementation had a significant effect in lowering plasma glucose, insulin, urinary glucose, and food intake. FA administration also increased the tolerance to intraperitoneal glucose loading and the hepatic glycogen content. In the food-restricted group, the reduced food intake slightly lowered the plasma and urinary glucose levels, but did not improve hyperinsulinemia and glucose tolerance. This study shows that FA had a hypoglycemic effect on KK-A^y mice, and the reduced food consumption was not a major factor which contributed to the hypoglycemic action of FA.
社団法人日本農芸化学会の論文
1998-10-23