Suppressive Effect of Coffee on Lipopolysaccharide-induced Hepatitis in D-Galactosamine-sensitized Rats(Food & Nutrition Science)
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概要
- 論文の詳細を見る
A coffee extract significantly suppressed lipopolysaccharide (LPS)-induced hepatitis in D-galactosamine-sensitized rats, as assessed by the plasma alanine and aspartate aminotransferase activities, when it was added to the diet (30 g/kg) and fed to rats for 14 days. Its effect was as strong as that of a green tea extract. The coffee extract suppressed LPS-induced hepatitis when singly force-fed (1.2 g/kg) 1.5 h prior to the injection of the drugs, whereas a decaffeinated coffee extract had no significant effect. The hepatoprotective effect of caffeine was stronger than that of theobromine. These results indicate that coffee can protect animals from LPS-induced hepatitis, and that the effect of coffee might be mainly due to caffeine.
- 社団法人日本農芸化学会の論文
- 2001-08-23
著者
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SUGIYAMA Kimio
Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University
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HE Puming
Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University
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He P
Shizuoka Univ. Shizuoka Jpn
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Sugiyama K
Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
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NODA Yasuhiro
Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University
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He Puming
Department Of Applied Biochemistry Faculty Of Agriculture Shizuoka University
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Sakata Kanzo
Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
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Sugiyama Kimio
Department Of Applied Biochemistry Faculty Of Agriculture Shizuoka University
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Sakata K
Institute For Chemical Research Kyoto University
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Noda Y
Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
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SUGIYAMA Kimio
Department of Agricultural Chemistry, Faculty of Agriculture, Shizuoka University
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