1-Methylmalate from Camu-Camu (Myrciaria dubia) Suppressed D-Galactosamine-Induced Liver Injury in Rats
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概要
- 論文の詳細を見る
To evaluate the protective effects of fruit juices against D-galactosamine (GalN)-induced liver injury, lyophilized fruit juices (total 12 kinds) were fed to rats for 7 d, and then we evoked liver injury by injecting GalN. The juice of camu-camu (Myrciaria dubia) significantly suppressed GalN-induced liver injury when the magnitude of liver injury was assessed by plasma alanine aminotransferase and aspartate aminotransferase activities, although some other juices (acerola, dragon fruit, shekwasha, and star fruit) also tended to have suppressive effects. An active compound was isolated from camu-camu juice by solvent fractionation and silica gel column chromatography. The structure was determined to be 1-methylmalate. On the other hand, malate, 1,4-dimethylmalate, citrate, and tartrate had no significant effect on GalN-induced liver injury. It is suggested that 1-methylmalate might be a rather specific compound among organic acids and their derivatives in fruit juices in suppressing GalN-induced liver injury.
- 社団法人 日本農芸化学会の論文
- 2010-03-23
著者
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Akachi Toshiyuki
The United Graduate School Of Agricultural Science Gifu University
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SHIINA Yasuyuki
Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University
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KAWAGISHI Hirokazu
Graduate School of Science and Technology, Shizuoka University
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MORITA Tatsuya
Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University
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SUGIYAMA Kimio
Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University
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Kawaguchi Takumi
Dep. Of Applied Biological Chemistry Fac. Of Agriculture Shizuoka Univ.
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Kawaguchi Takumi
Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
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Sugiyama Kimio
静岡大学 農 応用生物化学科
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Sugiyama Kimio
静岡大学 農学部応用生物化学
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Morita Tatsuya
静岡大学 農学部応用生物化学
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Morita Tatsuya
Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
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Shiina Yasuyuki
Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
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Kawagishi Hirokazu
Graduate School Of Science And Technology Shizuoka University
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Kawagishi Hirokazu
Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
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Kawagishi Hirokazu
Graduate School Of Sci. And Technol. Shizuoka Univ.
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杉山 公男
Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
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Sugiyama Kimio
岐阜大学 連合農学研究科
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Morita Tatsuya
岐阜大学 連合農学研究科
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Sugiyama Kimio
Department Of Applied Biochemistry Faculty Of Agriculture Shizuoka University
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杉山 公男
静岡大学 農学部応用生物化学科
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Hayashi Kanako
Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
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赤地 利幸
大和製罐株式会社 総合研究所
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SUGIYAMA Kimio
Department of Agricultural Chemistry, Faculty of Agriculture, Shizuoka University
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