Eritadenine-induced Alterations of Plasma Lipoprotein Lipid Concentrations and Phosphatidylcholine Molecular Species Profile in Rats Fed Cholesterol-free and Cholesterol-enriched Diets(Food & Nutrition Science)
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概要
- 論文の詳細を見る
The effects of dietary eritadenine on the concentration of plasma lipoprotein lipids and the molecular species profile of plasma lipoprotein phosphatidylcholine (PC) were investigated in rats fed cholesterol-free and cholesterol-enriched diets to obtain insights into the relationship between the changes in PC molecular species profile and the hypocholesterolemic action of eritadenine. The effect of eritadenine on the secretion rate of very low density lipoprotein (VLDL) from the liver was also estimated. Rats were fed the control or eritadenine-supplemented (50 mg/kg) diets with or without exogenous cholesterol for 14 d. Eritadenine supplementation significantly decreased the cholesterol of major plasma lipoproteins, high density lipoprotein and VLDL, in rats fed cholesterol-free and cholesterolenriched diets, respectively. The ratio of PC to phosphatidylethanolamine, Δ6-desaturase activity, and the ratio of arachidonic acid to linoleic acid in liver microsomes were markedly decreased by eritadenine irrespective of the presence or absence of exogenous cholesterol. Dietary eritadenine increased the proportion of 16 : 0-18 : 2 molecular species with a decrease in 18 : 0-20 : 4 in plasma lipoprotein PC in both rats fed cholesterol-free and cholesterol-enriched diets. Eritadenine did not depress the secretion rate of VLDL in rats fed a cholesterol-free diet containing a high level of choline. The results indicate that dietary eritadenine elicits its hypocholesterolemic action with modulations of the fatty acid and molecular species profiles of PC irrespective of the presence or absence of exogenous cholesterol. The eritadenine-induced alteration of PC molcular species profile is discussed in relation to the hypocholesterolemic action of eritadenine.
- 社団法人日本農芸化学会の論文
- 2003-05-23
著者
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MORITA Tatsuya
Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University
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SUGIYAMA Kimio
Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University
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Sugiyama Kimio
静岡大学 農 応用生物化学科
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Sugiyama Kimio
静岡大学 農学部応用生物化学
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Morita Tatsuya
静岡大学 農学部応用生物化学
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Morita Tatsuya
Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
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Morita Tatsuya
Dep. Of Applied Biological Chemistry Fac. Of Agriculture Shizuoka Univ.
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SHIMADA Yasuhiko
Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University
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Shimada Yukihisa
Tsukuba Research Laboratories Kyowa Hakko Co. Ltd.:(present Address)plant Functions Laboratory The I
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杉山 公男
Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
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Sugiyama K
Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
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Sugiyama Kimio
岐阜大学 連合農学研究科
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Morita T
Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
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Sugiyama Kimio
Department Of Applied Biochemistry Faculty Of Agriculture Shizuoka University
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杉山 公男
静岡大学 農学部応用生物化学科
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Shimada Yasuhiko
Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
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SUGIYAMA Kimio
Department of Agricultural Chemistry, Faculty of Agriculture, Shizuoka University
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