Quantitative Analysis of the Antimicrobial Activity and Membrane-perturbation Potencyof Antifouling Para-substituted Alkylphenols
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概要
- 論文の詳細を見る
To better understand the antifouling action of para-substituted phenolic compounds, the antimicrobial activity, which is known to be related to the antifouling activity, was examined with Trychophyton mentagrophytes. The effect of phenolic compounds on mitochondrial swelling was also investigated to elucidate their membrane-perturbation action. The variation of each activity was quantitatively analyzed by a regression analysis, using hydrophobic substituent parameter π. Each activity varied parabolically with increasing hydrophobicity of the para-substituent, the optimum π value being ca. 3. 5-4. 0. The introduction of a bulky substituent to the ortho position resulted in a drastic decrease in each activity. It is therefore likely that the antimicrobial activity is due to perturbation of the membrane structure. Considering the good correlation between the antifouling and antimicrobial activities of para-substituted phenols, the antifouling activity is assumed to be related to perturbation of the membrane structure and/or function.
- 社団法人日本農芸化学会の論文
- 1994-03-23
著者
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Watanabe N
Faculty Of Agriculture Shizuoka University
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Hayashi M
The Kitasaro Institute And School Of Pharmaceutical Sciences The Kitasato University
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Sugiyama Kimio
Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
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Iwamura Hajime
Department of Agricultural Chemistry, Faculty of Agriculture, Kyoto University
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Etoh Hideo
Faculty of Agriculture, Shizuoka University
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Ban Nobuyoshi
Faculty of Agriculture, Shizuoka University
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Fujiyoshi Junko
Faculty of Agriculture, Shizuoka University
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Murayama Nobuko
Faculty of Agriculture, Shizuoka University
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Sugiyama Kimio
Faculty of Agriculture, Shizuoka University
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Watanabe Naoharu
Faculty of Agriculture, Shizuoka University
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Sakata Kanzo
Faculty of Agriculture, Shizuoka University
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Ina Kazuo
Faculty of Agriculture, Shizuoka University
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Miyoshi Hideto
Department of Agricultural Chemistry, Kyoto University
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Hayashi Mitsuo
Institute For Life Science Research Asahi Chemical Industry Co. Ltd.
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Miyoshi H
Gakushuin Univ. Tokyo Jpn
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Miyoshi H
Kyoto Univ. Kyoto
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Miyoshi Hideto
Department Of Agricultural Chemistry Faculty Of Agriculture Kyoto University
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Ina Kazuo
Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University
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Hayashi Masahiko
Kitasato Institute For Life Sciences Kitasato University And The Kitasato Institute
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Watanabe Naoharu
Faculty Of Agriculture Shizuoka University
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Sugiyama K
Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
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Ina K
Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
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Etoh H
Faculty Of Agriculture Shizuoka University
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Etoh Hideo
Faculty Of Agriculture Shizuoka University
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Etoh Hideo
Faculty Of Pharmaceutical Sciences Meijo University
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Sakata Kanzo
Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
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Sakata Kanzo
Faculty Of Agriculture Shizuoka University
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Ban Nobuyoshi
Faculty Of Agriculture Shizuoka University
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Iwamura Hajime
Department Of Agricultural Chemistry Faculty Of Agriculture Kyoto University
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Iwamura Hajime
Department Of Agricultural Chemistry Kyoto University
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Sugiyama Kimio
Faculty Of Agriculture Shizuoka University
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Sakata K
Institute For Chemical Research Kyoto University
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Murayama Nobuko
Faculty Of Agriculture Shizuoka University
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Shimokihara Keiko
Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
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Fujiyoshi Junko
Faculty Of Agriculture Shizuoka University
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