Uncoupling Action of Antibiotic Sporaviridins with Rat-liver Mitochondria
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概要
- 論文の詳細を見る
The effects of the glycoside antibiotic sporaviridins (SVDs) on oxidative phosphorylation of rat-liver mitochondria were examined. SVDs released state 4 respiration, dissipated transmembrane electrical potential, and accelerated ATPase activity. These facts demonstrated that SVDs are potent uncouplers of oxidative phosphorylation. During the uncoupling caused by SVDs, large amplitude swelling and oxidation of intramitochondrial NAD(P)H occurred, suggesting that SVDs greatly enhanced nonspecific permeability of the inner mitochondrial membrane. It is suggested that the uncoupling action of SVDs might be caused by dissipation of proton electrochemical potential due to an increase in the permeability of inner mitochondrial membrane.
- 社団法人日本農芸化学会の論文
- 1992-11-23
著者
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Hayashi M
The Kitasaro Institute And School Of Pharmaceutical Sciences The Kitasato University
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HARADA Ken-ichi
Faculty of Pharmacy, Meijo University
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Suzuki Megumi
Department Of Applied Biological Chemistry Faculty Of Agriculture Niigata University
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SUZUKI Makoto
Faculty of Pharmacy, Meijo University
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Murata H
Forestry & Forest Products Res. Inst. Ibaraki Jpn
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Iwamura Hajime
Department of Agricultural Chemistry, Faculty of Agriculture, Kyoto University
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Miyoshi Hideto
Department of Agricultural Chemistry, Kyoto University
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Hayashi Mitsuo
Institute For Life Science Research Asahi Chemical Industry Co. Ltd.
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Miyoshi H
Gakushuin Univ. Tokyo Jpn
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Miyoshi H
Kyoto Univ. Kyoto
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Miyoshi Hideto
Department Of Agricultural Chemistry Faculty Of Agriculture Kyoto University
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Suzuki M
Yamagata Univ. Yamagata Jpn
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Murata H
Faculty Of Agriculture Miyazaki University
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Hayashi Masahiko
Kitasato Institute For Life Sciences Kitasato University And The Kitasato Institute
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Harada Ken-ichi
Faculty Of Pharmacy Meijo University
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Suzuki Masakatsu
Laboratory Of Animal Products Chemistry
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Harada K
Hokkaido Electric Power Co. Inc. Hokkaido Jpn
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Iwamura H
Department Of Bio-technology School Of Biology-oriented Science And Technology Kinki University
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Iwamura Hajime
Department Of Agricultural Chemistry Faculty Of Agriculture Kyoto University
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TAMAKI Motohito
Department of Agricultural Chemistry, Kyoto University
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MURATA Hideaki
Faculty of Pharmacy, Meijo University
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Tamaki Motohito
Department Of Agricultural Chemistry Kyoto University
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Ina H
Tokyo College Of Pharmacy
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Suzuki Makoto
Faculty Of Pharmacy Meijo University
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Suzuki Makoto
Faculty Of Engineering Niigata University
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