Structure Elucidation of Glykenin, Glycosidic Antibiotics from Basidiomycetes sp. VI. Structure Characterization of the GK Components Using Frit-FAB LC/MS
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概要
- 論文の詳細を見る
The structures of the glycosidic antibiotics, the glykenin (GK) family, produced by Basidiomycetes sp. were characterized using frit-FAB LC/MS. The GK was separated into nine components (GK-I-VII and DG) with differences in the number and positions of the acetyl groups in the sugar moiety. Although each of these components is further composed of three isomers depending on the three aglycones, it was difficult to isolate individual components because of the presence of the labile acetyl groups in the sugar moiety. For this reason, frit-FAB LC/MS in the negative ion mode was used for the structure characterization of each component. Three peaks were found in the mass chromatogram of each GK component monitored for the molecular ion species. The fragment ions related to the aglycone and sugar moieties were observed in each mass spectrum. Their molecular weights, the locations of the acetyl groups and the presence of three aglycones were confirmed using these ions. Furthermore, a profile analysis of the GK mixture was possible using a gradient elution mode.
- 日本質量分析学会の論文
- 1995-02-28
著者
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Meevootisom V.
マヒドン大・理
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HARADA Ken-ichi
Faculty of Pharmacy, Meijo University
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Meevootisom V
Faculty Of Science Mahidol University
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Meevootisom Vithaya
Faculty Of Science Mahidol University
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Harada K
Meijo Univ. Nagoya Jpn
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Flegel T
Faculty Of Science Mahidol University
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SUZUKI Makoto
Faculty of Pharmacy, Meijo University
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Suzuki M
Faculty Of Pharmacy Meijo University
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NISHIDA Fumiko
Faculty of Pharmacy, Meijo University
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MEEVOOTISOM Vithaya
Mahidol University
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FLEGEL Timothy
Mahidol University
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THEBTARANONTH Yodohathai
Mahidol University
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INTARARUANGSORN Suthum
Mahidol University
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MASUDA Katsuyoshi
Faculty of Pharmacy, Meijo University
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Harada Ken-ichi
Faculty Of Pharmacy Meijo University
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Harada K
Faculty Of Pharmacy Meijo University
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Masuda K
Meijo Univ. Nagoya
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Masuda Katsuyoshi
Faculty Of Pharmacy Meijo University
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Harada Keita
Department Of Biology Faculty Of Sience Osaka City University
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Nishida Fumiko
Instrumental Analytical Chemistry Faculty Of Pharmacy Meijo University
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Nishida Fumiko
Faculty Of Pharmacy Meijo University
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Intararuangsorn Suthum
Faculty Of Science Mahidol University
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Thebtharanonth Yodohathai
Faculty Of Science Mahidol University
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Suzuki Makoto
Faculty Of Pharmacy Meijo University
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Suzuki Makoto
Faculty Of Engineering Niigata University
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