The crystal and molecular structure of albocycline.

スポンサーリンク

概要

• 論文の詳細を見る

• The detailed molecular geometry of albocycline (C<SUB>18</SUB>H<SUB>28</SUB>O<SUB>4</SUB>) has been examined by X-ray crystal analysis. The crystals are monoclinic, with four molecules in a unit cell with dimensions of <I>a</I>=16.177(2), <I>b</I>=9.562(1), <I>c</I>=11.742(2) Å, and β=90.43(1)°; the space group is P2<SUB>1</SUB>. 3062 unique intensity data were collected on a four-circle diffractometer with graphite-monochromated Mo <I>K</I>α radiation. The structure was elucidated by the Monte Carlo direct method, using the 30 reflections with the greatest |<I>E</I>| values as the starting set; the 174th random phase set led to the correct solution. The <I>R</I> value reached 0.057 by block-diagonal least-squares refinements. The two crystallographically-independent molecules are connected by two O–H···O hydrogen bonds, forming a hydrogen-bonded dimer. The conformations of the fourteen-membered macrolide rings in these two molecules are considerably different from each other; <I>e.g.</I>, great differences of 165, 153, and 108° are found for the torsion angles around the C(4)–C(5), C(6)–C(7), and C(7)–C(8) single bonds respectively.

• 公益社団法人 日本化学会の論文

著者

• Harada Ken-ichi

  Faculty Of Pharmacy Meijo University

• Nakatsu Kazumi

  Faculty Of Science Kwansei Gakuin University

• Kinoshita Kenji

  Faculty Of Pharmaceutical Sciences Toho University

• Matsumoto Takeshi

  Department Of Biology Faculty Of Science Kumamoto University

• Suzuki Makoto

  Faculty Of Engineering Niigata University

• FURUSAKI Akio

  Department of Chemistry, Faculty of Science, Hokkaido University

• Hayashi Mitsuo

  Faculty of Science, Kwansei Gakuin University

関連論文

• Transvalencin Z, a New Antimicrobial Compound with Salicylic Acid Residue from Nocardia transvalensis IFM 10065
• Biotransformation of Bile Acids by Pathogenic Actinomycetes Nocardia otitidiscaviarum and Amycolatopsis sp. Strains
• Isolation and Structural Characterization of Siderophores, Madurastatins, Produced by a Pathogenic Actinomadura madurae
• Purification of quinoline yellow components using high-speed counter-current chromatography by stepwise increasing the flow-rate of the mobile phase
• Separation of spiramycin components using high-speed counter-current chromatography
• Identification of Lac Dye Components by Electrospray High Performance Liquid Chromatography-Tandem Mass Spectrometry.
• Total Structures of Colistin Minor Components
• Identification of Lac Dye Components by Electrospray High Performance Liquid Chromatography-Tandem Mass Spectrometry
• Improvement of chemical analysis of antibiotics XXIII : Identification of residual tetracyclines in bovine tissues by electrospray high-performance liquid chromatography-tandem mass spectrometry
• Total Structures and Antimicrobial Activity of Bacitracin Minor Components
• Hepatitis B and C Viruses Infection, Lifestyle and Genetic Polymorphisms as Risk Factors for Hepatocellular Carcinoma in Haimen, China
• Elevated levels of soluble fibrin in patients with venous thromboembolism
• Negative predictive value of D-dimer for diagnosis of venous thromboembolism
• Hybrid Biosynthesis by Targeted Inactivation of Polyketide Synthases in the Mycinamicin Producer, Micromonospora griseorubida
• Biomechanical Analysis of TMJ Soft Tissues under Asymmetric Jaw Movement(3D1 Dental Biomechanics)
• P-06 TRANSPORT MODEL OF PHYSIOLOGICAL SUBSTANCES IN CORTICAL BONE THROUGH POROUS CANAL NETWORK
• Synthesis of 2-Methyl 16-Membered Macrolide Derived from Tylosin
• Ployketide Synthase Gene Coupled to the Peptide Synthetase Module Involved the Biosynthesis of the Cyclic Heptapeptide Microcystin
• Three-dimensional quantitative analysis of glomerular microcirculatoion in diabetic nephropathy using syncrotron radiation X-ray micro-CT
• A Coupled Assay System for the Lysis of Cyanobacteria
• Goadsporin, a Chemical Substance witch Promotes Secondary Metabolism and Morphogenesis in Streptomycetes : II. Structure Determination
• ON VON NEUMANN REGULARITY, INJECTIVITY AND FLATNESS
• Structure Elucidation of Glykenin, Glycosidic Antibiotics from Basidiomycetes sp. VI. Structure Characterization of the GK Components Using Frit-FAB LC/MS
• Directed Biosynthesis of Fluorinated Pseurotin A, Synerazol and Gliotoxin
• Arisostatins A and B, New Members of Tetrocarcin Class of Antibiotics from Micromonospora sp. TP-A0316 : II. Structure Determination
• Digital Radiographic Quantification of Myocardial Blood Flow Around a Transmyocardial Laser Channel in Rabbit Hearts
• Daily Changes of Nutritional Status in Partially Hepatectomized Rats Receiving Total Parenteral Nutrition(Food & Nutrition)
• Uncoupling Mechanism of Glycoside Antibiotic Aculeximycin in Isolated Rat-Liver Mitochondria
• Structural Elucidation of Aculeximycin IV.Absolute Structure of Aculeximycin, Belonging to a New Class of Macrolide Antibiotics
• Structural Elucidation of Aculeximycin III.Planar Structure of Aculeximycin, Belonging to a New Class of Macrolide Antibiotics
• Uncoupling Action of Antibiotic Sporaviridins with Rat-liver Mitochondria
• Inactivation of Fusidic Acid by Pathogenic Nocardia
• Microcystin production during algal bloom occurrence in Laguna de Bay, the Philippines
• Genetic Analysis of the Peptide Synthetase Genes for a Cyclic Heptapeptide Microcystin in Microcystis spp.
• X-Ray Halo Scattering from Liquid Crystals
• Small Angle X-Ray Scattering near Nematic-Isotropic Transition Temperature
• X-Ray Study of Phase Transition in Liquid Crystals
• Coronary microcirculation : Physiology and mechanics
• High-intensity signals in the basal ganglia from gadolinium-enhanced T1-weighted MRI as an early change in toxoplasma encephalitis in an AIDS patient
• Microcirculatory heterogeneity of myocardial oxygen supply-consumption balance and flow in crystalloid-perfused rat hearts under hypoxia
• A New Proposal for Crossing Two or More Sheaths through Single Trans-Septal Puncture in Ablation of Atrial Fibrillation : Experience with Steerable Introducer
• Pretreatment of Immobilized Candida antarctica Lipase for Biodiesel Fuel Production from Plant Oil
• Biodiesel Fuel Production from Plant Oil Catalyzed by Rhizopus oryzae Lipase in a Water-Containing System without an Organic Solvent
• Importance of Imaginary Chemical Potential for QCD Phase Diagram in the PNJL Model(QCD Phase Diagram,New Frontiers in QCD 2010-Exotic Hadron Systems and Dense Matter-)
• Myocardial microvascular perfusion after transfusion of liposome-encapsulated hemoglobin evaluated in cross-circulated rat hearts using tracer digital radiography
• Effect of Artificial Red Blood Cells on Renal Microcirculation and Tissue Oxygen in DIC Rats(Thrombosis/Thrombolysis 2 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Increased Moleculer Mass of Hemicellulosic Polysaccharides is involeved in Growth Inhibition of Maize Coleoptiles and Mesocotyls under Hypergravity Conditions
• Pradimicin S, A New Pradimicin Analog III.Application of the Erit-FAB LC/MS Technique to the Elucidation of the Pradimicin S Biosynthetic Pathway
• Desorption Chemical Ionization Mass Spectra of Underivatized Abscisic Acid-conjugated Metabolites, a Useful Aid for Structural Characterization(Organic Chemistry)
• Mass Spectrometric Studies of Peptides from Cyanobacteria under FAB MS/MS Conditions
• Direct Transformation of Unprotected Sugars to Aryl 1-Thio-β-glycosides in Aqueous Media Using 2-Chloro-1,3-dimethylimidazolinium Chloride
• Mass Spectrometric Analysis of Cyanobacterial Toxins (BMS特集号) -- (水とMS)
• Comparative Study on Desorption CI and Molecular SIMS for Aminoglycoside Antibiotics Containing Aminoacyl Group (イオン化特集)
• A New Glycosphingolipid from the Red Alga Corallina pilulifera
• Is the Ryukyu subduction zone in Japan coupled or decoupled? : The necessity of seafloor crustal deformation observation
• B-5-4 Structure of Lampterol(Terpenoids)
• Infrared Polarized Reflection Spectra of SrTiO_3 Thin Films on Metal/Si
• An Equivalence Checking Method for C Descriptions Based on Symbolic Simulation with Textual Differences(Simulation and Verification, VLSI Design and CAD Algorithms)
• Prevention of coronary slow flow/no reflow during percutaneous coronary intervention by the use of embolic protection device, 'Filtrap'
• Mg-Promoted Stereoselective Desulfonation of β-Arylvinyl Sulfone Derivatives
• Effect of Acetyl-phosphate and Pyridoxalphosphate on the Induced Synthesis of Peroxidase in Pseudomonas aeruginosa
• Mechanical Properties of Single Trabecula at Microscale : Elastic Modulus, Hardness and X-ray Diffraction Intensity(Micro- and Nano-biomechanics)
• Impact of chronic cyanosis and reoxygenation on the microheterogeneity of the myocardial blood flow : digital radiographic study in neonatal rats
• Increased fibrinolysis increases bleeding in orthopedic patients receiving prophylactic fondaparinux
• Monitoring for anti-Xa activity for prophylactic administration of Fondaparinux in patients with artificial joint replacement
• Characterization of the locus of genes encoding enzymes producing heptadepsipeptide micropeptin in the unicellular cyanobacterium Microcystis
• Frequent association of thrombophilia in cerebral venous sinus thrombosis
• The crystal and molecular structure of grayanotoxin XVIII. A new minor diterpene from Leucothoe Grayana Max.
• The crystal and molecular structure of grayanotoxin XIX. A new minor diterpene from Leucothoe grayana Max.
• Structures and Phytotoxicity of Metabolites from Valsa ceratosperma
• Δ9(10)-Octal-1-one and its Molecular Compound
• Efficacy of Early Intravenous Immunoglobulin for Eosinophilic Granulomatosis with Polyangiitis with Drastically Progressive Neuropathy: A Synopsis of Two Cases
• Structural Characterization of Abscisic Acid and Related Metabolites by Chemical Ionization Mass Spectrometry
• Characterization of a New Abscisic Acid-conjugated Metabolite in Crude Plant Extract by Desorption Chemical Ionization and Secondary Ion Mass Spectrometry
• A stereoselective total synthesis of methyl .ALPHA.-DL-daunosaminide.
• Molecular structure of 5.BETA.,6.BETA.-isopropylidenedioxy-15,16,17-trinorgrayan-10(20)-ene-3,14-dione as revealed by X-ray methods.
• Synthesis of Alkoxycyclopropane Derivatives, Intermediates in the Synthesis of Hirsutic Acid
• The crystal and molecular structure of pikromycin.
• Evaluation of Viscoelastic Property of Articular Cartilage Based on Mechanical Model Considering Tissue Microstructure
• X-ray structure of (10R)-10-bromo-10-deoxyhexahydrolaurefucin.
• The crystal and molecular structure of the photodimer of biphenylene.
• X-Ray Crystal Structure of Pyrenocine A, a Phytotoxin from Pyrenochaeta terrestris
• The crystal and molecular structure of palythine trihydrate.
• X-Ray structure of (1RS, 5RS, 7SR)-1-acetoxy-7-cyano-5-methylbicyclo-(3.2.0)heptan-2-one, a photocycloadduct of 2-acetoxy-3-methyl-2-cyclopenten-1-one and acrylonitrile.
• Trimethylsilyl triflate induced reaction of humulene 6,7-epoxide. Cyclization to 5-hydroxy-4,8,11,11-tetramethyltricyclo(6.3.0.02,4)undec-9-ene.
• Structure and Biological Activity of Bottrospicatol, a Novel Monoterpene Produced by Microbial Transformation of (-)-cis-Carveol
• Synthesis of hypacrone.
• Various acceleration conditions of Pummerer reaction observed in the total synthesis of illudins.
• Enzymatic synthesis of new pyridine nucleosides. Clitidine and its amide derivative.
• A cyclization of humulene by means of a mercuric salt in aceto- and benzonitrile.
• Synthesis of 5,5-Dimethyl-4-acetoxy-2-cyclopentenone, an Intermediate in the Total Synthesis of Illudin M, through Sulfur Compounds. A Novel Intramolecular Migration of Ethylenedioxy Group
• Stereospecific Reductions of Isoilludin S and M on Alumina Chromatography
• Serotobenine, a Novel Phenolic Amide from Safflower Seeds (Carthamus tinctorius L.)
• The Molecular and Crystal Structure of the p-Bromobenzoate of an Unusual Birch Reduction Product
• The Crystal Structure of d,l-1,1,4aα-Trimethyl-2α-hydroxy-8α-acetoxy-1,2,3,4,4α,5,6,7,8,9-decahydrophenanthrene
• Synthesis of 5,5-Dimethyl-4-acetoxy-2-cyclopentenone and 5-Methyl-t-5-acetoxymethyl-r-4-acetoxy-2-cyclopentenone Intermediates for Illudin M and S
• Lead tetraacetate oxidation of humulene and conformational analysis of the produced humulatrienediols.
• The crystal and molecular structure of albocycline.
• Uncoupling Mechanism of Glycoside Antibiotic Aculeximycin in Isolated Rat-Liver Mitochondria.
• Polyketide Synthase Gene Coupled to the Peptide Synthetase Module Involved in the Biosynthesis of the Cyclic Heptapeptide Microcystin.

もっと見る 閉じる

スポンサーリンク