Efficacy of Early Intravenous Immunoglobulin for Eosinophilic Granulomatosis with Polyangiitis with Drastically Progressive Neuropathy: A Synopsis of Two Cases
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概要
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Two women, 66-year-old and 63-year-old, were admitted for drastically progressive neuropathy, and diagnosed with eosinophilic granulomatosis with polyangiitis (EGPA). Steroid pulse therapy failed to exert effect upon neuropathy, so we administered early intravenous immunoglobulin (IVIG) for fear of immobilization of neuropathy. This resulted in marked improvement in neuropathy without apparent side effects. Recent evidence suggests the efficacy of IVIG for steroid refractory neuropathy associated with EGPA, but has previously been administered during the chronic phase resulting in slow improvement. Our two successfully treated cases indicate the efficacy of early IVIG in preventing the immobilization of neuropathy, especially in progressive cases.
著者
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Nagata Kazuma
Department of Respiratory Medicine, Kobe City Medical Center General Hospital, Japan
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Imai Yukihiro
Department Of Clinical Pathology Kobe City General Hospital
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Oka Nobuyuki
Department Of Internal Medicine Shimane Medical University
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Matsumoto Takeshi
Department Of Biology Faculty Of Science Kumamoto University
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Tachikawa Ryo
Department of Respiratory Medicine, Kobe City Medical Center General Hospital, Japan
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Tachikawa Ryo
Department of Respiratory Medicine, Kobe City Medical Center General Hospital
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Kawamoto Michi
Department of Neurology, Kobe City Medical Center General Hospital
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Tomii Keisuke
Department of Pulmonary Medicine, Kobe City General Hospital
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Otsuka Kojiro
Department of Respiratory Medicine, Kobe City Medical Center General Hospital, Japan
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Oka Nobuyuki
Department of Neurology, Minami-Kyoto National Hospital, Japan
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