The crystal and molecular structure of staurosporine, a new alkaloid from a Streptomyces strain.

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概要

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• The molecular sturcture of staurosporine, an alkaloid from a <I>Streptomyces</I> strain, has been determined by means of an X-ray crystallographic analysis of its methanol solvate (C<SUB>28</SUB>H<SUB>26</SUB>N<SUB>4</SUB>O<SUB>3</SUB>·CH<SUB>3</SUB>OH). The crystals are monoclinic, with four formula units in a unit cell with dimensions of <I>a</I>=23.487(6), <I>b</I>=7.636(3), <I>c</I>=15.638(4) Å, and β=116.71(5)°; the space group is C2. 2532 unique intensity data were collected on a four-circle diffractometer with LiF-monochromated Cu Kα radiation. The structure was solved by the Monte Carlo direct method, using the 20 strongest reflections as the starting set; the 72nd random phase set led to the correct solution. The <I>R</I> value reached 0.047 by block-diagonal least-squares refinements. Staurosporine has been found to contain a unique dimeric indole structure. Because of the steric hindrance, the indolo[2,3-<I>a</I>]carbazole aromatic system in the molecule is slightly bent; the two terminal benzene rings make an angle of 7.5° with each other.

• 公益社団法人 日本化学会の論文

著者

• IWAI Yuzuru

  The Kitasato Institute

• Matsumoto Takeshi

  Department Of Biology Faculty Of Science Kumamoto University

• FURUSAKI Akio

  Department of Chemistry, Faculty of Science, Hokkaido University

• Hashiba Nobuhiro

  Department of Chemistry, Faculty of Science, Hokkaido University

• Hirano Atsushi

  The Kitasato Institute and Kitasato University

• Iwai Yuzuru

  The Kitasato Institute and Kitasato University

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