Neurobehavioral effects of combined prenatal exposure to low-level mercury vapor and methylmercury

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概要

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• We evaluated the effects of prenatal exposure to low-level mercury (Hg0) or methylmercury (MeHg) as well as combined exposure (Hg0 + MeHg exposure) on the neurobehavioral function of mice. The Hg0 exposure group was exposed to Hg0 at a mean concentration of 0.030 mg/m3 for 6 hr/day during gestation period. The MeHg exposure was supplied with food containing 5 ppm of MeHg from gestational day 1 to postnatal day 10. The combined exposure group was exposed to both Hg0 vapor and MeHg according to above described procedure. After delivery, when their offspring reached the age of 8 weeks, behavioral analysis was performed. Open field (OPF) tests of the offspring showed an increase and decrease in voluntary activity in male and female mice, respectively, in the MeHg exposure group. In addition, the rate of central entries was significantly higher in this group than in the control group. The results of OPF tests in the Hg0 + MeHg exposure group were similar to those in the MeHg exposure group in both males and females. The results in the Hg0 exposure group did not significantly differ from those in the control group in males or females. Passive avoidance response (PA) tests revealed no significant differences in avoidance latency in the retention trial between the Hg0, MeHg, or Hg0 + MeHg exposure group and the control group in males or females. Morris water maze tests showed a delay in the latency to reach the platform in the MeHg and Hg0 + MeHg exposure groups compared with the control group in males but no significant differences between the Hg0, MeHg, or Hg0 + MeHg exposure group and the control group in females. The results of OPF tests revealed only slight effects of prenatal low-level Hg0 exposure (0.03 mg/m3), close to the no-observable-effect level (NOEL) stated by the WHO (0.025 mg/m3), on the subsequent neurobehavioral function. However, prenatal exposure to 5 ppm of MeHg affected exploratory activity in the OPF test, and, in particular, male mice were highly sensitive to MeHg. The MeHg and Hg0 + MeHg exposure groups showed similar neurobehavioral effects. Concerning the effects of prenatal mercury exposure under the conditions of this study, the effects of MeHg exposure may be more marked than those of Hg0 exposure.

• 2011-02-01

著者

• Yasutake A

  National Inst. For Minamata Disease Kumamoto Jpn

• Yasutake Akira

  Biochemistry Section National Inst. For Minamata Disease

• Yasutake Akira

  Biochemistry Section Department Of Basic Medical Sciences National Institute For Minamata Disease

• Yasutake Akira

  National Inst. For Minamata Disease

• SEO Makoto

  Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University

• YOSHIDA Minoru

  Faculty of Human Health Sciences, Hachinohe University

• Suzuki Megumi

  Department Of Applied Biological Chemistry Faculty Of Agriculture Niigata University

• Watanabe Chiho

  Department of Human Ecology, Graduate School of Medicine, University of Tokyo

• Seo Makoto

  Laboratory Of Hygienic Chemistry And Molecular Toxicology Gifu Pharmaceutical University

• Watanabe Chiho

  Department Of Environmental Health Sciences Tohoku University School Of Medicine

• Satoh Masahiko

  Laboratory Of Pharmaceutical Health Sciences School Of Pharmacy Aichi Gakuin University

• Watanabe Chiho

  Department Of Human Ecology Graduate School Of Medicine University Of Tokyo

• Satoh Masahiko

  Laboratory Of Hygienic Chemistry And Molecular Toxicology Gifu Pharmaceutical University

• Suzuki Megumi

  Department Of Chemistry Meisei University

• Yoshida Minoru

  Faculty Of Human Health Sciences Hachinohe University

• Yoshida Minoru

  Facul. Of Med. Res. Inst. For Dis. Of Chest Kyushu University

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