Severe toxicity and cyclooxygenase (COX)-2 mRNA increase by lithium in the neonatal mouse kidney

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概要

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• Functions of the kidney of mammals are immature during the neonatal period, and the neonatal kidney could be susceptible to chemicals, including drugs and environmental toxicants. Among these chemicals, cyclooxygenase (COX)-inducing chemicals should be given attentions as the potential kidney toxicants during the period, and we hypothesized that lithium chloride (LiCl) has such toxicity. Neonatal mice of C57BL/J strain were intraperitoneally injected with LiCl (2mmol/kg body weight) daily until 21 days of age, and examined on 7 days and 21 days of age. Neonatal treatment of LiCl caused a significant increase in COX-2 mRNA and a decrease in mRNAs of aquaporins on day 7 of age. Osmolarity of urine from LiCl-treated neonates was significantly lower than that of control neonate. Most of the LiCl-treated neonates died during the second week of age. Histological examination revealed renal cysts on day 7 and hydronephrosis on day 21. in the surviving neonates. The present results showed that the kidney of mouse neonates is vulnerable to lithium, and suggested the possibility that COX-2 upregulation is responsible for the severe renal toxicity including hydronephrosis.

• 日本トキシコロジー学会の論文
• 2009-10-01

著者

• TOHYAMA Chiharu

  Center of Disease Biology and Integrated Medicine, Faculty of Medicine, The University of Tokyo

• Watanabe Chiho

  Department of Human Ecology, Graduate School of Medicine, University of Tokyo

• Watanabe Chiho

  Department Of Environmental Health Sciences Tohoku University School Of Medicine

• Nishimura Noriko

  Research Center for Environmental Risk, National Institute for Environmental Studies

• Tohyama Chiharu

  Center For Disease Biology And Integrative Medicine Graduate School Of Medicine University Of Tokyo

• Tohyama Chiharu

  Center For Disease Biology And Integrative Medicine Graduate School Of Medicine University Of Tokyo:

• Watanabe Chiho

  Department Of Human Ecology Graduate School Of Medicine University Of Tokyo

• Akagi Toshiya

  Center For Disease Biology And Integrative Medicine Graduate School Of Medicine University Of Tokyo

• Watanabe Chiho

  Dep. Of Human Ecology Graduate School Of Medicine Univ. Of Tokyo

• Yoshioka Wataru

  Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, University of Toky

• Shimizu Hana

  Department of Human Ecology, School of International Health, Graduate School of Medicine, University

• Nishimura Noriko

  Research Center For Environmental Risk National Institute For Environmental Studies

• Yoshioka Wataru

  Center For Disease Biology And Integrative Medicine Graduate School Of Medicine University Of Tokyo

• Tohyama Chiharu

  Center For Biological Safety Research National Institute Of Health Sciences Environmental Health Sci

• Shimizu Hana

  Department Of Human Ecology School Of International Health Graduate School Of Medicine University Of

• Shimizu Hana

  Department Of Human Ecology School Of International Health Graduate School Of Medicine The University Of Tokyo

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