Negative Correlation between Urinary Selenium and Arsenic Levels of the Residents Living in an Arsenic-Contaminated Area in Bangladesh

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概要

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• Toxicological and metabolic interactions of selenium (Se) with arsenic (As) have been reported in many experimental studies. However, for human populations, possible interactions between As and Se and their toxicological significance have not been established. In this study, we have examined the relationship between Se and As in spot urine samples collected from the inhabitants of two rural communities of northeast Bangladesh. The urinary As (U_<As>) and Se (U_<Se>) concentrations were determined by hydride generation atomic absorption spectrometry (HGAAS). Negative correlation between U_<As> and U_<Se> was found in both males and females. Considering the exposure condition in these communities, it is unlikely that the correlation reflected the correlation between the intakes of these elements. This result suggests that As exposure from drinking water or food may change Se metabolism in humans. Possible toxicological significance of the interaction is discussed.

• 公益社団法人日本薬学会の論文
• 2003-06-01

著者

• Watanabe Chiho

  Department of Human Ecology, Graduate School of Medicine, University of Tokyo

• Watanabe Chiho

  Department Of Human Ecology School Of International Health Graduate School Of Medicine University Of

• Watanabe Chiho

  Department Of Environmental Health Sciences Tohoku University School Of Medicine

• MIYAZAKI KAORI

  Department of Geriatric Medicine, Tokyo Medical University

• OHTSUKA Ryutaro

  Department of Human Ecology, School of Medicine, University of Tokyo

• INAOKA Tsukasa

  Department of Public Health, Kumamoto University School of Medicine

• Miyazaki K

  Department Of Human Ecology School Of International Health Graduate School Of Medicine University Of

• Miyazaki Kaori

  Department Of Gastroenterology Graduate School Of Comprehensive Human Science University Of Tsukuba

• Inaoka T

  Department Of Environmental Sociology Faculty Of Agriculture Saga University

• Inaoka Tsukasa

  Department Of Environmental Sociology Faculty Of Agriculture Saga University

• USHIJIMA Kayo

  Department of Public Health, Kumamoto University School of Medicine

• Ushijima K

  Department Of Public Health Kumamoto University School Of Medicine

• Ushijima Kayo

  Department Of Public Health School Of Medicine Fukuoka University

• Kadono Takefumi

  Department of Dermatology, University of Tokyo

• Kadono Takefumi

  Department Of Dermatology University Of Tokyo

• Ohtsuka Ryutaro

  National Inst. Environmental Studies Ibaraki Jpn

• Ohtsuka Ryutaro

  Department Of Human Ecology School Of International Health Graduate School Of Medicine University Of

• Ohtsuka Ryutaro

  Department Of Human Ecology Graduate School Of Medical Sciences The University Of Tokyo

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