Chlorella suppresses methylmercury transfer to the fetus in pregnant mice
スポンサーリンク
概要
- 論文の詳細を見る
To investigate the effects of chlorella on methylmercury (MeHg) transfer to the fetus during pregnancy, female C57BL/6N mice (aged 10 weeks) were housed for 7 to 8 weeks, from 4 weeks before mating to birth, with diets containing 0% or 10% chlorella powder (CP) and MeHg-containing drinking water (2 µg Hg/ml). The consumption volume of the MeHg-containing water was limited to 15 ml/mouse/week throughout the experiment. Distilled water and a basal diet (0% CP) was given to control mice. Except for the mating period, during the 5th week, mice were housed individually until parturition. Two neonates were randomly selected from each mother mouse within 24 hr after parturition for Hg analysis of the blood, brain, liver, and kidneys. Mother mice were sacrificed on the same day as neonates to obtain tissue samples for Hg analysis. The blood and brain Hg levels of both neonates and mothers in the CP diet group were significantly lower than those in the basal diet group. Although the hepatic and renal Hg levels were not significant in mothers between the two dietary groups, in neonates, the CP diet group showed significantly lower Hg levels in these tissues than the basal diet group. The results obtained here revealed that continuous CP intake suppressed MeHg transfer to the fetus, in addition to effective suppressing MeHg accumulation in brains of the mothers.
- 日本トキシコロジー学会の論文
著者
-
UCHIKAWA Takuya
Department of Research & Development, Chlorella Industry Co., Ltd.
-
KUMAMOTO Shoichiro
Department of Research & Development, Chlorella Industry Co., Ltd.
-
ANDO Yotaro
Department of Research & Development, Chlorella Industry Co., Ltd.
-
Yasutake Akira
Biochemistry Section Department Of Basic Medical Sciences National Institute For Minamata Disease
-
Maruyama Isao
Department Of Research & Development Chlorella Industry Co. Ltd.
-
Maruyama Isao
Department Of Biological Sciences Faculty Of Science University Of Kanagawa
-
Kumamoto Shoichiro
Department Of Research & Development Chlorella Industry Co. Ltd.
-
Uchikawa Takuya
Department Of Research & Development Chlorella Industry Co. Ltd.
関連論文
- The influence of Parachlorella beyerinckii CK-5 on the absorption and excretion of methylmercury (MeHg) in mice
- Demethylation of Methylmercury in Human Neuroblastoma, Glioblastoma and Liver Cells
- Resistance of human brain microvascular endothelial cells in culture to methylmercury : cell-density-dependent defense mechanisms
- Suppression of fibroblast growth factor-2 expression : Possible mechanism underlying methylmercury-induced inhibition of the repair of wounded monolayers of cultured human brain microvascular endothelial cells
- Methylmercury Retards the Repair of Wounded Monolayer of Human Brain Microvascular Endothelial Cells by Inhibiting Their Proliferation without Nonspecific Cell Damage
- Neurotoxic action of inorganic mercury injected in the intraventricular space of mouse cerebrum
- Nontrivial Quantized Berry Phases for Itinerant Spin Liquids(Condensed matter : structure and mechanical and thermal properties)
- Selective and Simple Quantification of Metallothionein III in Mouse Brain
- Kinetic Study on Methylmercury Uptake by Rat Erythrocytes (Proceedings of the 19th Symposium on Toxicology and Environmental Health)
- Effects of Iron Overload on Hepatic and Renal Metallothionein Levels in Rats
- Mechanism of Methylmercury Efflux from Rat Astrocytes (Proceedings of the 19th Symposium on Toxicology and Environmental Health)
- Simple Method for Methylmercury Estimation in Biological Samples Using Atomic Absorption Spectroscopy
- Reappraisal of the Historic 1959 Cat Experiment in Minamata by the Chisso Factory
- Chronic Effects of Methylmercury in Rats : II. Pathological Aspects
- Chronic Effects of Methylmercury in Rats : I. Biochemical Aspects
- "P-15 Biological Effects of Chronic Exposure to Methylmercury of Low Level.
- Influence of Dietary Levels of Protein and Sulfur Amino Acids on Metabolism of Glutathione and Related Amino Acids in Mice
- Role of Mitochondria in Biotransformation of Methylmercury (Proceedings of the 23rd Symposium on Toxicology and Environmental Health)
- Influence of Dietary Protein Levels on the Acute Toxicity of Methylmercury in Mice (Proceedings of the 21st Symposium on Toxicology and Environmental Health)
- Influence of Dietary Protein Levels on the Subacute Toxicity of Methylmercury in Mice (Proceedings of the 20th Symposium on Toxicology and Environmental Health)
- Influence of Supplementary Sulfur Amino Acids on the Fate of Methylmercury in Mice Fed on a Low Protein Diet
- Studies on Plasma Methylmercury Compound and Its Brain Uptake (Proceedings of the 16 th Symposium on Environmental Pollutants and Toxicology)
- Influence of Low Protein Diet on the Fate of Methylmercury and Tissue Glutathione Levels (Regular Presentations) (Proceedings of the 15 th Symposium on Environmental Pollutants and Toxicology)
- Sex Difference of Acute Toxicity of Methylmercury in Mice (Proceedings of the 14th Symposium on Environmental Pollutants and Toxicology)
- Current Hair Mercury Levels in Japanese for Estimation of Methylmercury Exposure
- Current Hair Mercury Levels in Japanese : Survey in Five Districts
- Acute Phase Effects of Methylmercury on Glutathione Metabolisms (Proceedings of the 20th Symposium on Toxicology and Environmental Health)
- Wistar-Imamichi Rats Exhibit a Strong Resistance to Cadmium Toxicity
- Increase of Calcium Concentration in the Testes of Mice Treated with Rare Earth Metals
- Neurobehavioral effects of combined prenatal exposure to low-level mercury vapor and methylmercury
- The enhanced elimination of tissue methylmercury in Parachlorella beijerinckii-fed mice
- Collateral occurrence of deimination of keratins with differentiation of an immortalized newborn rat keratinocyte cell line cultured at air-liquid interface
- Chlorella suppresses methylmercury transfer to the fetus in pregnant mice
- Methylmercury inhibits electron transport chain activity and induces cytochrome c release in cerebellum mitochondria
- Induction by mercury compounds of metallothioneins in mouse tissues : inorganic mercury accumulation is not a dominant factor for metallothionein induction in the liver
- Site-Specific Induction of Metallothionein in N-Nitrosodimethylamine-Treated Rat Liver
- Neurobehavioral changes and alteration of gene expression in the brains of metallothionein-I/II null mice exposed to low levels of mercury vapor during postnatal development
- Chronic Low-Dose Methylmercury Administration Decreases Mitochondrial Enzyme Activities and Induces Myopathic Changes in Rats
- Chlorella suppresses methylmercury transfer to the fetus in pregnant mice
- Neurobehavioral changes and alteration of gene expression in the brains of metallothionein-I/II null mice exposed to low levels of mercury vapor during postnatal development
- Uniform Matrix Product State in the Thermodynamic Limit
- Effect of dental amalgam on gene expression profiles in rat cerebrum, cerebellum, liver and kidney
- Distribution of mercury in metallothionein-null mice after exposure to mercury vapor : amount of metallothionein isoform does not affect accumulation of mercury in the brain
- Quantum Entanglement of Tensor Networks with Symmetry Projections