Convergent Synthesis of Arisugacin Skeletons and Their Acetylcholinesterase Inhibitory Activity

スポンサーリンク

概要

• 論文の詳細を見る
• 2001-04-25

著者

• Hayashi M

  The Kitasaro Institute And School Of Pharmaceutical Sciences The Kitasato University

• Hayashi M

  Kitasato Institute For Life Sciences Kitasato University And The Kitasato Institute

• Hayashi Mitsuo

  Institute For Life Science Research Asahi Chemical Industry Co. Ltd.

• Omura Satoshi

  Research Center For Biological Function The Kitasato Institute And School Of Pharmaceutical Sciences

• SUNAZUKA Toshiaki

  Research Center for Biological Function, The Kitasato Institute and School of Pharmaceutical Science

• HARIGAYA Yoshihiro

  Research Center for Biological Function, The Kitasato Institute and School of Pharmaceutical Science

• Miyoshi Hideto

  Kyoto Univ. Kyoto Jpn

• OTOGURO KAZUHIKO

  Research Center for Tropical Diseases, The Kitasato Institute

• Nagai Kenichiro

  Kitasato Institute For Life Sciences And Graduate School Of Infection Control Sciences Kitasato Univ

• Sunazuka T

  信州大学医学部附属病院 薬剤部

• Sunazuka Toshiaki

  Kitasato Univ. Tokyo Jpn

• Hayashi Masahiko

  Kitasato Institute For Life Sciences Kitasato University And The Kitasato Institute

• Otoguro Kazuhiko

  Research Centre For Tropical Diseases The Kitasato Institute

• Otoguro Kazuhiko

  Kitasato Inst. Tokyo Jpn

• Otoguro Kazuhiko

  Research Center For Biological Function The Kitasato Institute

• Otoguro K

  Research Centre For Tropical Diseases The Kitasato Institute

• Koyama Nobuhiro

  School Of Pharmacy Kitasato University

• Tian Zhiming

  Research Center For Biological Function The Kitasato Institute And Kitasato University

• HANDA Masaki

  Research Center for Biological Function, The Kitasato Institute and Kitasato University

• NAGAI Kenichiro

  Research Center for Biological Function, The Kitasato Institute and Kitasato University

• KIMURA Ryouko

  Research Center for Biological Function, The Kitasato Institute and Kitasato University

• SHIRAHATA Tatsuya

  Research Center for Biological Function, The Kitasato Institute and Kitasato University

• TIAN Zhi-Ming

  Research Center for Biological Function, The Kitasato Institute and Kitasato University

• Takamatsu S

  Univ. Mississippi Ms Usa

• Shirahata Tatsuya

  Research Center For Biological Function The Kitasato Institute And Kitasato University

• Kimura Ryouko

  Research Center For Biological Function The Kitasato Institute And Kitasato University

• Harigaya Y

  School Of Pharmacy Kitasato University

• Omura Satoshi

  Research Center For Biological Function The Kitasato Institute

関連論文

• Production of the New Antibiotic Tetrahydrokalafungin by Transformants of the Kalafungin Producer Streptomyces tanashiensis
• Isolation of Restriction-reduced Mutants from Streptomyces(Microbiology & Fermentation Industry)
• Biochemical and Spectroscopic Properties of Cyanide-Insensitive Quinol Oxidase from Gluconobacter oxydans
• Application of PCR for Selection of Gram-Positive Bacteria with High DNA G+C Content among New Isolates
• Quantitative Analysis of the Antimicrobial Activity and Membrane-perturbation Potencyof Antifouling Para-substituted Alkylphenols
• New Analogs of the Pyripyropene Family of ACAT Inhibitors via α-Pyrone Fragmentation and γ-Acylation/Cyclization
• Kinetic Mechanism of Quinol Oxidation by Cytochrome bd Studied with Ubiquinone-2 Analogs
• Mitochondrial Dehydrogenases in the Aerobic Respiratory Chain of the Rodent Malaria Parasite Plasmodium yoelii yoelii
• Microbial Conversion of EM574 and EM523, Gastrointestinal motor Stimulating Agents
• Bioactive Metabolites of EM574 and EM523, Erythromycin Derivatives Having Strong Gastrointestinal Motor Stimulating Activity
• Vagus-Dependent and Vagus-Independent Mechanisms of Action of the Erythromycin Derivative EM574 and Motilin in Dogs
• Total Synthesis of Madindolines, Potent Selective Inhibitors of Interleukine 6, Novel Bioactive Microbial Metabolites
• Construction of a single Component Producer from the Wild Type Avermectin Producer Streptomyces avermitilis
• The Neuritogenesis Inducer Lactacystin Arrests Cell Cycle at Both Go/G1 and G2 Phases in Neuro 2a Cells
• Direct Production of 5-Oxo Derivatives of Avermectins by a Recombinant Strain of Streptomyces avermitilis
• Arohynapene D, a New Anticoccidial Agent Produced by Penicillium sp.FO-2295
• Fudecalone, a New Anticoccidial Agent Produced by Penicillium sp.FO-2030
• Terpendoles, Novel ACAT Inhibitors Produced by Albophoma yamanashiensis II.Structure Elucidation of Terpendoles A, B, C and D
• Terpendoles, Novel ACAT Inhibitors Produced by Albophoma yamanashiensis I.Production, Isolation and Biological Properties
• Isolation and Characterization of Covalently Closed Circular DNA Associated with Chromosomal and Membrane Fraction from Streptomyces ambofaciens
• Genetic and Biochemical Features of Spiramycin Biosynthesis in Streptomyces ambofaciens--Curing,Protoplast Regeneration and Plasmid Transfer
• Extraction and Characterization of Plasmids from Macrolide Antibiotic-Producing Streptomycetes
• Structural Modification of the Lincomycin Antibiotic
• Chemical Synthesis and Structural Study of Lincomycin Sulfoxides and a Sulfone
• Semisynthetic Modification of Antibiotic Lincomycin
• Dechlorogeodin and Its New Dihydro Derivatives, Fungal Metabolites with Herbicidal Activity
• Chlovalicin, a New Cytocidal Antibiotic Produced by Sporothrix sp. FO-4649 II. Physicochemical Properties and Structural Elucidation
• Chlovalicin, a New Cytocidal Antibiotic Produced by Sporothrix sp. FO-4649 I. Taxon9omy, Fermentation, Isolation and Biological Activities
• Andrastins A-S, New Protein Farnesyltransferase Inhibitors Produced by Penicillium sp. F)-3929 I. producing Strain, Fermentation, Isolation, and Biological Activities
• Herquline B, a New Platelet Aggregation Inhibitor Produced by Penicillium herquei Fg-372
• Macrosphelide, a Novel Inhibitor of Cell-cell Adhesion Molecule I.Taxonomy, Fermentation, Isolation and Biological Activities
• Isochromophilones III~VI, Inhibitors of Acyl-CoA:Cholesterol Acyltransferase Produced by Penicillium multicolor FO-3216
• A New Anti-influenza Virus Antibiotic, 10-Norparvulenone from Microsphaeropsis sp. FO-5050
• A New Antimicrobial Antibiotic from Actinoplanes capillaceus sp. K95-5561^T
• New Members of the Macrosphelides from Microsphaeropsis sp. FO-5050 IV
• Phenopyrrozin, a New Radical Scavenger Produced by Penicillium sp.FO-2047
• New Glycosidases Inhibitors, Panosialins D and wD Produced by StreptOmyces sp.OH-5186
• Verticipyrone, a New NADH-fumarate Reductase Inhibitor, Produced by Verticillium sp. FKI-1083
• Paecilaminol, a New NADH-Fumarate Reductase Inhibitor, Produced by Paecilomyces sp. FKI-0550
• Aγ-Lactone Form Nafuredin, Nafuredin-γ, also Inhibits Helminth Complex I
• Parasite Mitochondria as a Target for Chemotherapy
• Isolation of a New Antibiotic Oligomycin G Produced by Streptomyces sp. WK-6150
• Ferroverdins, Inhibitors of Cholesteryl Ester Transfer Protein Produced by Streptomyces sp. WK-5344 I. Production, Isolation and Biological Properties
• Photometric Analyses of Optically-Trapped Single Microparticles in Solution
• Antimalarial Activity of Radicicol, Heptelidic Acid and Other Fungal Metabolites
• Two New Components of the Aspochalasins Produced by Aspergillus sp.
• Reversal of Multidrug Resistance by 7-O-Benzoylpyripyropene A in Multidrug-Resistant Tumor Cells
• Enhancement of Drug Accumulation by Andrastin A Produced by Penicillium sp. FO-3929 in Vincristine-resistant KB Cells
• Madindolines, Novel Inhibitors of IL-6 Activity from Streptomyces sp. K93-0711 II. Physico-chemical Properties and Structural Elucidation
• Macrosphelides C and D, Novel Inhibitors of Cell Adhesion
• Amphistin, a New Melanogenesis Inhibitor, Produced by an Actinomycete
• Efficient Chemical Conversion of Louisianin A to C and D, The Inhibitor of Angiogenesis
• Pyridindolols K1 and K2, New Alkaloids from Streptomyces sp. K93-0711
• Madindoline, a Novel Inhibitor of IL-6 Activity from Streptomyces sp. K93-0711 I. Taxonomy, Fermentation, Isolation and Biological Activities
• A New Inhibitor of Melanogenesis, Albocycline K3, Produced by Streptomyces sp. OH-3984
• Macrosphelide, a Novel Inhibitor of Cell-cell Adhesion Molecule II. Physicochemical Properties and Structural Elucidation
• Louisianins A, B, C and D:Non-steroidal Growth Inhibitors of Testosterone-responsive SC 115 Cells II.Physico-chemical Properties and Structural Elucidation
• Louisianins A, B, C and D:Non-steroidal Growth Inhibitors of Testosterone-responsive SC 115 Cells I.Taxonomy, Fermentation, Isolation and Biological Characteristics
• Stachybocins, Novel Endothelin Receptor Antagonists, Produced by Stachybotrys sp.M6222 II.Structure Determination of Stachybocins A, Band C
• Stachybocins, Novel Endothelin Receptor Antagonists, Produced by Stachybotrys sp.M6222 I.Taxonomy, Fermentation, Isolation and Characterization
• Argadin, a New Chitinase Inhibitor, Produced by Clonostachys sp.FO-7314
• Argifin, a New Chitinase Inhibitor, Produced by Gliocladium sp. FTD-0668 : I. Taxonomy, Fermentation, and Biological Activities
• Synthesis and Inhibitory Activities of Isochromophilone Analogues against gp120-CD4 Binding
• Structure-specific Inhibition of Cholesteryl Ester Transfer Protein by Azaphilones
• Pyripyropenes, Novel ACAT Inhibitors Produced by Aspergillus fumigatus III.Structure Elucidation of Pyripyropenes E to L
• Synthesis and Anti-platelet Aggregation Activity of Water-soluble Staurosporine Derivatives
• Staurosporine, a Potentially Important Gift from a Microorganism
• Uncoupling Mechanism of Glycoside Antibiotic Aculeximycin in Isolated Rat-Liver Mitochondria
• Uncoupling Action of Antibiotic Sporaviridins with Rat-liver Mitochondria
• Effect of 14-Membered Ring Macrolide Compounds on Rat Leucocyte Chemotaxis and the Structure-activity Relationships
• Effcects of Erythromycin and Its Derivatives on Interlcukin-8 Release by Human Bronchial Epithelial Cell Line BEAS-2B Cells
• Characterization of the Ubiquinol Oxidation Sites in Cytochromes bo and bd from Escherichia coli using Aurachin C Analogues
• Synthesis and Antiangiogenic Activity of Staurosporine Derivatives
• Zelkovamycin, a New Cyclic Peptide Antibiotic from Streptomyces sp. K96-0670 I. Production, Isolation and Biological Properties
• Chloropeptins, New Anti-HIV Antibiotics Inhibiting gp120-CD4 Binding from Streptomyces sp. I. Taxonomy, Fermentation, Isolation, and Physico-chemical Properties and Biological Activities
• Chemical Modification and Structure-activity Relationships of Pyripyropenes 1. Modification at the Four Hydroxyl Groups
• Structure-activity Relationships of Pyripyropenes Fungal Acyl-CoA:Cholesterol Acyltransferase Inhibitors
• Physalins Possessing an Endoperoxy Structure from Physalis alkekengi var. francheti. Structural Revision of Physalin K
• Heme-dependent Radical Generation from Antimalarial Fungal Metabolites, Radicicol ad Heptelidic acid
• Andrastins A-C, New Protein Farnesyltransferase Inhibitors Produced by Penicillium sp. FO-3929 II. Structure Elucidation and Biosynthesis
• Terpendoles, Novel ACAT Inhibitors Produced by Albophoma yamanashiensis III.Production, Isolation and Structure Elucidation of New Components
• Potent Antimalarial Activities of Polyether Antibiotic, X-206
• Funalenone, a Novel Collagenase Inhibitor Produced by Aspergillus niger
• Novel Cyclopentanone Derivatives Pentenocins A and B, with Interleukin-1βConverting Enzyme Inhibitory Activity, Produced by Trichoderma hamatum FO-6903
• Malolactomycins C and D, New 40-Membered Macrolides Active against Botrytis
• Amidepsine E, an Inhibitor of Diacylglycerol Acyltransferase Produced by Humicola sp. FO-5969
• Nafuredin, a Novel Inhibitor of NADH-fumarate Reductase, Produced by Aspergillus niger FT-0554
• Total Syntheses of the AChE Inhibitors (±)-Arisugacins F and G
• Determination of Absolute Stereochemistries of Arisugacin F and Territrem B, Novel Acetylcholinesterase Inhibitors
• Convergent Synthesis of Arisugacin Skeletons and Their Acetylcholinesterase Inhibitory Activity
• Structure-activity Relationships Study of Pyripyropenes : Reversal of Cancer Cell Multidrug Resistance
• Structure-activity Relationships of Lactacystin, the First Non-protein Neurotrophic Factor
• Pyripyropenes, Novel ACTA Inhibitors Produced by Aspergillus Fumigatus IV. Structure Elucidation of Pyripyropenes M to R
• Characterization of Actinomycetes Isolated from Fallen Leaves
• Hydranthomycin, a New Agroactive Antibiotic Produced by Streptomyces sp.K93-5305
• Screening Method for Cellulose Biosynthesis Inhibitors with Herbicidal Activity
• New Brominated and Halogen-less Derivatives and Structure-activity Relationship of Azaphilones Inhibiting gp120-CD4 Binding
• Chloropeptins, New Anti-HIV Antibiotics Inhibiting gp120-CD4 Binding from Streptomyces sp. II. Structure Elucidation of Chloropeptin I
• Structure Elucidation of Roselipins, Inhibitors of Diacylglycerol Acyltransferase Produced by Gliocladium roseum KF-1040
• A Tightly Bound Quinone Functions in the Ubiquinone Reaction Sites of Quinoprotein Alcohol Dehydrogenase of an Acetic Acid Bacterium, Gluconobacter suboxydans

もっと見る 閉じる

スポンサーリンク