The Change in Conjugated Linoleic Acid Concentration in Blood of Japanese Fed a Conjugated Linoleic Acid Diet
スポンサーリンク
概要
- 論文の詳細を見る
Conjugated linoleic acid (CLA) is a collective term used for fatty acids with a conjugated double bond that are geometrical and positional isomers of linoleic acid. Anti-obesity and anti-cancer properties, an immunopotentiation effect, and promotion of bone formation by CLA have been shown in cell culture and animal studies. A mixture of 9c11t- and 10t12c-CLA is now used as a health food supplement after testing in clinical trials. These trials focused on improvement of lipid metabolism by CLA, whereas few studies have examined absorption and metabolism of CLA in humans. In addition, there is no report concerning absorption and metabolism of CLA in Japanese. This study was designed to examine CLA concentration in blood, the elimination rate of CLA, and metabolic differences between 9c11t-CLA and 10t12c-CLA in blood in Japanese who ingested CLA (about 2 g/d, equal weights of 9c11t-CLA and 10t12c-CLA) for 3 wk. Blood samples were collected 1 wk before the 3-wk period, on the first and last days of the period, and 1 wk after the end of the period, and the CLA concentration and distribution in blood were investigated. The CLA concentration in blood was significantly increased by CLA ingestion and reached 36 μmol/L. The CLA concentration in blood one week after the intake period was significantly lower than that at the end of CLA intake. The 10t12c-CLA level in plasma decreased faster than that of 9c11t-CLA. This suggests faster metabolism (fatty acid β oxidation) of 10t12c-CLA compared with 9c11t-CLA.
著者
-
Ito Junya
Laboratory Of Animal Reproduction Azabu University
-
NOSAKA Naohisa
Central Research Laboratory, Nisshin OilliO Group
-
Ikeda Ikuo
Laboratory Of Food And Biomolecular Science Department Of Food Function And Health Division Of Biosc
-
SHINOHARA Nahoko
Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University
-
TSUDUKI Tsuyoshi
Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University
-
Shinohara Nahoko
Laboratory Of Food And Biomolecular Science Graduate School Of Agriculture Tohoku University
-
Tsuduki Tsuyoshi
Laboratory Of Food And Biomolecular Science Graduate School Of Agriculture Tohoku University
-
Aoyama Toshiaki
Central Research Laboratory Nisshin Oillio Group
-
Sato Kenta
Laboratory Of Food And Biomolecular Science Graduate School Of Agriculture Tohoku University
-
Honma Taro
Laboratory Of Food And Biomolecular Science Graduate School Of Agriculture Tohoku University
-
ARAI Tatsuya
Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University
-
Nosaka Naohisa
Central Res. Lab. The Nisshin Oillio Group Ltd.
-
Aoyama Toshiaki
Central Res. Lab. The Nisshin Oillio Group Ltd.
-
ITO Junya
Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University
-
NOSAKA Naohisa
Central Research Laboratory, The Nisshin OilliO Group, Ltd.
-
Aoyama Toshiaki
Central Research Laboratory, The Nisshin OilliO Group, Ltd.
関連論文
- Removal of Acrosomal Membrane from Sperm Head Improves Development of Rat Zygotes Derived from Intracytoplasmic Sperm Injection
- Effect of Life-Long Dietary n-6/n-3 Fatty Acid Ratio on Life Span, Serum Lipids and Serum Glucose in Wistar Rats
- Dietary Soy Protein Isolate and Its Undigested High Molecular Fraction Upregulate Hepatic ATP-Binding Cassette Transporter G5 and ATP-Binding Cassette Transporter G8 mRNA and Increase Biliary Secretion of Cholesterol in Rats
- Structured Triacylglycerol Containing Medium-Chain Fatty Acids in sn-1(3) Facilitates the Absorption of Dietary Long-Chain Fatty Acids in Rats
- Effects of Dietary Shrimp, Squid and Octopus on Serum and Liver Lipid Levels in Mice
- Effects of Dietary Fats and Curcumin on IgE-Mediated Degranulation of Intestinal Mast Cells in Brown Norway Rats
- Effects of Glyco- and Tauro-Cholic and Chenodeoxycholic Acids on Lymphatic Absorption of Micellar Cholesterol and Sitosterol in Rats
- Comparison of Effects of Dietary Unesterified and Esterified Plant Sterols on Cholesterol Absorption in Rats
- Dietary Gallate Esters of Tea Catechins Reduce Deposition of Visceral Fat, Hepatic Triacylglycerol, and Activities of Hepatic Enzymes Related to Fatty Acid Synthesis in Rats
- Cholesterol Esterase Bound to Intestinal Brush Border Membranes Does Not Accelerate Incorporation of Micellar Cholesterol into Absorptive Cells(Biochemistry & Molecular Biology)
- Lymphatic Transport of Dietary Cholesterol Oxidation Products, Cholesterol and Triacylglycerols in Rats(Food & Nutrition Science)
- Intestinal Absorbability of Wheat Allergens, Subunits of a Wheat α-Amylase Inhibitor, Expressed by Bacteria(Food & Nutrition Science)
- Concentration of Serum Lipids and Aortic Lesion Size in Female and Male Apo E-Deficient Mice Fed Docosahexaenoic Acid
- Effects of Docosahexaenoic and Eicosapentaenoic Acid on Lipid Metabolism, Eicosanoid Production, Platelet Aggregation and Atherosclerosis in Hypercholesterolemic Rats
- Effects of Dietary α-Linolenic, Eicosapentaenoic and Docosahexaenoic Acids on Hepatic Lipogenesis and β-Oxidation in Rats
- Ethylene Glycol-supplemented Calcium-free Media Improve Zona Penetration of Vitrified Rat Oocytes by Sperm Cells
- Current Topics in Food and Biodynamic Chemistry Research
- Vegetable Oil Enriched with Phytosterol Ester and the Degree of Serum Cholesterol Lowering Effect in Healthy Subjects
- Effects of Phytosterol Esters on Serum Lipids and Fecal Steroids Excretion in Hamsters
- Effects of Phytosterol Ester-Enriched Vegetable Oil on Serum Cholesterol and Assessment of Safety in Healthy Men
- Dietary Effect of EPA-rich and DHA-rich Fish Oils on the Immune Function of Sprague-Dawley Rats
- Oxysterol Regulation of Estrogen Receptor α-Mediated Gene Expression in a Transcriptional Activation Assay System Using HeLa Cells
- Effects of Feeding Oyster, Crassostrea gigas, on Serum and Liver Lipid Levels in Rats
- Protection Against the Diabetogenic Effect of Feeding tert-Butylhydroquinone to Rats Prior to the Administration of Streptozotocin
- Application of the Random Arbitrary Primed Polymerase Chain Reaction Differential Display Method to Isolate Genes of Cholesterol Metabolism-related Proteins from Rat Liver
- Effect of Dietary Seal and Fish Oils on Lipid Metabolism in Hamsters
- Effect of Dietary Seal and Fish Oils in Triacylglycerol Metabolism in Rats
- Lymphatic Absorption of Seal and Fish Oils and Their Effect on Lipid Metabolism and Eicosanoid Production in Rats
- Development of External Genitalia in Fetal and Neonatal Domestic Cats(Anatomy)
- Effect of Oleic Acid Level under Constant n-6/n-3 and P/S Ratios of Dietary Fats on Lipid Metabolism in Rats(Food & Nutrition)
- The P/S Ratio of Dietary Fats and Lipid Metabolism in Rats : Gamma-linolenic Acid as a Source of Polyunsaturated Fatty Acid(Food & Nutrition)
- Recommended Methods of Fatty Acid Methylester Preparation for Conjugated Dienes and Trienes in Food and Biological Samples
- Anti-angiogenic Activity of Tocotrienol(Food & Nutrition Science)
- Combined Intervention of Medium-Chain Triacylglycerol Diet and Exercise Reduces Body Fat Mass and Enhances Energy Expenditure in Rats
- Effect of Randomly Interesterified Triacylglycerols Containing Medium- and Long-Chain Fatty Acids on Energy Expenditure and Hepatic Fatty Acid Metabolism in Rats
- Effects of Ingestion of Margarine Containing Medium-Chain Triglycerides for 4 Weeks on Blood Parameters and Postprandial Thermogenesis
- Effects of Margarine Containing Medium-chain Triacylglycerols on Body Fat Reduction in Humans
- Effect of Medium-Chain Triglycerides on Postprandial Concentrations of Remnant-Like Particles in Healthy Men
- Effect of Medium-chain Triglycerides on the Postprandial Triglyceride Concentration in Healthy Men(Food & Nutrition Science)
- Effects of Dietary Medium-Chain Triacylglycerols on Serum Lipoproteins and Biochemical Parameters in Healthy Men(Food & Nutrition Sience)
- Decrease of Food Intake in Rats after Ingestion of Medium-Chain Triacylglycerol
- Effects of α-Tocopherol and Tocotrienols on Blood Pressure and Linoleic Acid Metabolism in the Spontaneously Hypertensive Rat (SHR)
- Reduction by Phytate-reduced Soybean β-Conglycinin of Plasma Triglyceride Level of Young and Adult Rats
- Effect of Soy and Milk Whey Protein Isolates and Their Hydrolysates on Weight Reduction in Genetically Obese Mice
- Physiological Effects of Water-soluble Soybean Fiber in Rats
- Hydrolysis of Micellar Phosphatidylcholine Accelerates Cholesterol Absorption in Rats and Caco-2 Cells
- Heat-Epimerized Tea Catechins Have the Same Cholesterol-Lowering Activity as Green Tea Catechins in Cholesterol-Fed Rats
- Lymphatic Absorption of Structured Triacylglycerols, 1(3)-Stearoyl-2, 3(1)-Dilinoleoylglycerol and 2-Linoleoyl-1, 3-Distearoylglycerol in Rats
- Influence of Tea Catechins on Lipid Metabolism
- Effects of Dietary Carbohydrates on Cholesterol Metabolism in Rats of Different Ages(Food & Nutrition)
- Improved Method for Preparation of the Methyl Ester of Conjugated Linoleic Acid〔和文〕
- Chinese Hypertriglycerideamic Subjects of Different Ages Responded Differently to Consuming Oil with Medium- and Long-Chain Fatty Acids
- Comparisons of the Effects of Dietary Fats on Serum and Liver Lipid Levels of Rats
- Larger Diet-Induced Thermogenesis and Less Body Fat Accumulation in Rats Fed Medium-Chain Triacylglycerols than in Those Fed Long-Chain Triacylglycerols
- Nutritional Effects of Randomly Interesterified and Physically Mixed Oils Containing Medium-chain Fatty Acids on Rats
- Effect of Medium-Chain Fatty Acids-Containing Dietary Oil on Hepatic Fatty Acid Oxidation Enzyme Activity in Rats
- Effects of Co-Administration of Tea Epigallocatechin-3-gallate (EGCG) and Caffeine on Absorption and Metabolism of EGCG in Humans
- Kinetics of Nuclear Status and Kinase Activities During In Vitro Maturation of Canine Oocytes
- Suppression of Postprandial Hypertriglyceridemia in Rats and Mice by Oolong Tea Polymerized Polyphenols
- Missense Mutation of Abcg5 in Stroke-Prone Spontaneously Hypertensive Rats Does Not Influence Lymphatic Sitosterol Absorption Regardless of the Dose : Comparison with Wistar Rats
- Missense Mutation in Abcg5 in SHRSP Rats Does Not Accelerate Intestinal Absorption of Plant Sterols : Comparison with Wistar Rats
- Effect of Dietary n-6/n-3 Ratio on Liver n-6/n-3 Ratio and Peroxisomal β-Oxidation Activity in Rats
- Increased Monocytic Adhesion by Senescence in Human Umbilical Vein Endothelial Cells
- Anti-Angiogenic Effects of Conjugated Docosahexaenoic Acid in Vitro and in Vivo
- Distribution of Tocotrienols in Rats Fed a Rice Bran Tocotrienol Concentrate
- Effect of Randomly Interesterified Triacylglycerol Containing Medium- and Long-Chain Fatty Acids on Hepatic Fatty Acid Oxidation after a Single Administration to Rats
- Chinese Hypertriglycerideamic Subjects of Different Ages Responded Differently to Consuming Oil with Medium- and Long-Chain Fatty Acids
- Effects of a High-Protein Diet on Host Resistance to Paracoccidioides brasiliensis in Mice
- Effect of Dietary Oils on Host Resistance to Fungal Infection in Psychologically Stressed Mice
- Validation of an Ion Trap Tandem Mass Spectrometric Analysis of Mulberry 1-Deoxynojirimycin in Human Plasma : Application to Pharmacokinetic Studies
- Effect of Dietary Oils on Lymphocyte Immunological Activity in Psychologically Stressed Mice
- Slow Absorption of Conjugated Linoleic Acid in Rat Intestines, and Similar Absorption Rates of 9c,11t-Conjugated Linoleic Acid and 10t,12c-Conjugated Linoleic Acid
- Dietary Alpha-Linolenic Acid Inhibits Angiotensin-Converting Enzyme Activity and mRNA Expression Levels in the Aorta of Spontaneously Hypertensive Rats
- Effect of Dietary Alpha-Linolenic Acid on Vascular Reactivity in Aorta of Spontaneously Hypertensive Rats
- Phosphorylation of inositol 1,4,5-triphosphate receptor 1 during in vitro maturation of porcine oocytes
- Factors Affecting Fertilization and Embryonic Development During Intracytoplasmic Sperm Injection in Pigs
- Lowering Systolic Blood Pressure and Increases in Vasodilator Levels in SHR with Oral α-Linolenic Acid Administration
- Possible involvement of phosphatidylinositol 3-kinase in the maintenance of metaphase II attest in porcine oocytes matured in vitro
- Increased lipid accumulation in liver and white adipose tissue in aging in the SAMP10 mouse
- Effect of Dietary Lard Containing Higher α-Linolenic Acid on Plasma Triacylglycerol in Rats
- The change in conjugated linoleic acid concentration in blood of Japanese fed a conjugated linoleic acid diet
- Increased Monocytic Adhesion by Senescence in Human Umbilical Vein Endothelial Cells
- The Metabolic Conversion of 9, 11, 13-Eleostearic Acid (18 : 3) to 9, 11-Conjugated Linoleic Acid (18 : 2) in the Rat
- Comparison of Diet-Induced Thermogenesis of Foods Containing Medium- versus Long-Chain Triacylglycerols
- Dietary Supplementation of Gamma-Linolenic Acid Improves Skin Parameters in Subjects with Dry Skin and Mild Atopic Dermatitis
- Jacaric Acid, a Linolenic Acid Isomer with a Conjugated Triene System, Reduces Stearoyl-CoA Desaturase Expression in Liver of Mice
- Effect of Dietary Linoleic, α-Linolenic and Arachidonic Acids on Lipid Metabolism, Tissue Fatty Acid Composition and Eicosanoid Production in Rats
- Increased Lipid Accumulation in Liver and White Adipose Tissue in Aging in the SAMP 10 Mouse
- Effect of a Liver X Receptor Agonist on Deposition and Lymphatic Absorption of Plant Sterols in Stroke-Prone Spontaneously Hypertensive Rats Having a Mutation in ATP-Binding Cassette Transporter G5
- High Developmental Rates of Mouse Oocytes Cryopreserved by an Optimized Vitrification Protocol : The Effects of Cryoprotectants, Calcium and Cumulus Cells
- SHRSP/Izm and WKY/NCrlCrlj Rats Having a Missense Mutation in Abcg5 Deposited Plant Sterols in the Body, but Did Not Change Their Biliary Secretion and Lymphatic Absorption—Comparison with Jcl:Wistar and WKY/Izm Rats
- The Change in Conjugated Linoleic Acid Concentration in Blood of Japanese Fed a Conjugated Linoleic Acid Diet
- SHRSP/Izm and WKY/NCrlCrlj Rats Having a Missense Mutation in Abcg5 Deposited Plant Sterols in the Body, but Did Not Change Their Biliary Secretion and Lymphatic Absorption-Comparison with Jcl : Wistar and WKY/Izm Rats
- Successful Production of Offspring Using Cryopreserved Sperm via Nonsurgical Artificial Insemination in Rats
- Physiological Effects and Tissue Distribution from Large Doses of Tocotrienol in Rats
- Dietary Fats Modulate Age-Dependent Effects of Dietary Proteins on Cholesterol Metabolism in Rats
- Effects of Dietary Short-Necked Clam, Tapes japonica, on Serum and Liver Cholesterol Levels in Mice.
- Lymphatic Transport of Stearic Acid and Its Effect on Cholesterol Transport in Rats.
- Dietary Cholesterol Influences on Various Lipid Indices and Eicosanoid Production in Rats Fed Dietary Fat Desirable for the Protection of Ischemic Heart Disease.
- Effects of Heat-Killed Lactobacillus pentosus S-PT84 on Postprandial Hypertriacylglycerolemia in Rats