Increased Monocytic Adhesion by Senescence in Human Umbilical Vein Endothelial Cells
スポンサーリンク
概要
- 論文の詳細を見る
We investigated whether replicative senescence of endothelial cells contributed to the pathogenesis of atherosclerosis in human umbilical vein endothelial cells (HUVECs). HUVECs at a population-doubling level of 30 (PDL30) divided much more slowly than those at PDL9. The percentage of SA-β-Gal-positive cells and the mRNA expression levels of PAI-1 and p21 at PDL30 were significantly higher than those at PDL9. The changes induced by aging were evaluated according to the mRNA expression level of genes related to the endothelial cell function. The expression level of many adhesion molecules promoting monocytic adhesion was significantly increased, and monocytic adhesion on HUVECs was found to be significantly promoted by aging. Monocytic adhesion is an essential early event in the development of atherosclerosis, and our results suggest that replicative senescence of the vascular endothelial cells induced increased expression of adhesion molecules. The consequent increase in monocytic adhesion may then promote the pathogenesis of atherosclerosis.
著者
-
Ito Junya
Laboratory Of Animal Reproduction Azabu University
-
Ikeda Ikuo
Laboratory Of Food And Biomolecular Science Department Of Food Function And Health Division Of Biosc
-
YANAKA Miyuki
Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University
-
HONMA Taro
Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University
-
SATO Kenta
Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University
-
SHINOHARA Nahoko
Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University
-
TANAKA Yurie
Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University
-
TSUDUKI Tsuyoshi
Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University
-
Shinohara Nahoko
Laboratory Of Food And Biomolecular Science Graduate School Of Agriculture Tohoku University
関連論文
- Removal of Acrosomal Membrane from Sperm Head Improves Development of Rat Zygotes Derived from Intracytoplasmic Sperm Injection
- Dietary Soy Protein Isolate and Its Undigested High Molecular Fraction Upregulate Hepatic ATP-Binding Cassette Transporter G5 and ATP-Binding Cassette Transporter G8 mRNA and Increase Biliary Secretion of Cholesterol in Rats
- Structured Triacylglycerol Containing Medium-Chain Fatty Acids in sn-1(3) Facilitates the Absorption of Dietary Long-Chain Fatty Acids in Rats
- Effects of Dietary Shrimp, Squid and Octopus on Serum and Liver Lipid Levels in Mice
- Effects of Dietary Fats and Curcumin on IgE-Mediated Degranulation of Intestinal Mast Cells in Brown Norway Rats
- Effects of Glyco- and Tauro-Cholic and Chenodeoxycholic Acids on Lymphatic Absorption of Micellar Cholesterol and Sitosterol in Rats
- Comparison of Effects of Dietary Unesterified and Esterified Plant Sterols on Cholesterol Absorption in Rats
- Dietary Gallate Esters of Tea Catechins Reduce Deposition of Visceral Fat, Hepatic Triacylglycerol, and Activities of Hepatic Enzymes Related to Fatty Acid Synthesis in Rats
- Cholesterol Esterase Bound to Intestinal Brush Border Membranes Does Not Accelerate Incorporation of Micellar Cholesterol into Absorptive Cells(Biochemistry & Molecular Biology)
- Lymphatic Transport of Dietary Cholesterol Oxidation Products, Cholesterol and Triacylglycerols in Rats(Food & Nutrition Science)
- Intestinal Absorbability of Wheat Allergens, Subunits of a Wheat α-Amylase Inhibitor, Expressed by Bacteria(Food & Nutrition Science)
- Concentration of Serum Lipids and Aortic Lesion Size in Female and Male Apo E-Deficient Mice Fed Docosahexaenoic Acid
- Effects of Docosahexaenoic and Eicosapentaenoic Acid on Lipid Metabolism, Eicosanoid Production, Platelet Aggregation and Atherosclerosis in Hypercholesterolemic Rats
- Effects of Dietary α-Linolenic, Eicosapentaenoic and Docosahexaenoic Acids on Hepatic Lipogenesis and β-Oxidation in Rats
- Ethylene Glycol-supplemented Calcium-free Media Improve Zona Penetration of Vitrified Rat Oocytes by Sperm Cells
- Dietary Effect of EPA-rich and DHA-rich Fish Oils on the Immune Function of Sprague-Dawley Rats
- Oxysterol Regulation of Estrogen Receptor α-Mediated Gene Expression in a Transcriptional Activation Assay System Using HeLa Cells
- Effects of Feeding Oyster, Crassostrea gigas, on Serum and Liver Lipid Levels in Rats
- Protection Against the Diabetogenic Effect of Feeding tert-Butylhydroquinone to Rats Prior to the Administration of Streptozotocin
- Application of the Random Arbitrary Primed Polymerase Chain Reaction Differential Display Method to Isolate Genes of Cholesterol Metabolism-related Proteins from Rat Liver
- Effect of Dietary Seal and Fish Oils on Lipid Metabolism in Hamsters
- Effect of Dietary Seal and Fish Oils in Triacylglycerol Metabolism in Rats
- Lymphatic Absorption of Seal and Fish Oils and Their Effect on Lipid Metabolism and Eicosanoid Production in Rats
- Development of External Genitalia in Fetal and Neonatal Domestic Cats(Anatomy)
- Effect of Oleic Acid Level under Constant n-6/n-3 and P/S Ratios of Dietary Fats on Lipid Metabolism in Rats(Food & Nutrition)
- The P/S Ratio of Dietary Fats and Lipid Metabolism in Rats : Gamma-linolenic Acid as a Source of Polyunsaturated Fatty Acid(Food & Nutrition)
- Effects of α-Tocopherol and Tocotrienols on Blood Pressure and Linoleic Acid Metabolism in the Spontaneously Hypertensive Rat (SHR)
- Hydrolysis of Micellar Phosphatidylcholine Accelerates Cholesterol Absorption in Rats and Caco-2 Cells
- Heat-Epimerized Tea Catechins Have the Same Cholesterol-Lowering Activity as Green Tea Catechins in Cholesterol-Fed Rats
- Lymphatic Absorption of Structured Triacylglycerols, 1(3)-Stearoyl-2, 3(1)-Dilinoleoylglycerol and 2-Linoleoyl-1, 3-Distearoylglycerol in Rats
- Influence of Tea Catechins on Lipid Metabolism
- Effects of Dietary Carbohydrates on Cholesterol Metabolism in Rats of Different Ages(Food & Nutrition)
- Improved Method for Preparation of the Methyl Ester of Conjugated Linoleic Acid〔和文〕
- Comparisons of the Effects of Dietary Fats on Serum and Liver Lipid Levels of Rats
- Kinetics of Nuclear Status and Kinase Activities During In Vitro Maturation of Canine Oocytes
- Suppression of Postprandial Hypertriglyceridemia in Rats and Mice by Oolong Tea Polymerized Polyphenols
- Missense Mutation of Abcg5 in Stroke-Prone Spontaneously Hypertensive Rats Does Not Influence Lymphatic Sitosterol Absorption Regardless of the Dose : Comparison with Wistar Rats
- Missense Mutation in Abcg5 in SHRSP Rats Does Not Accelerate Intestinal Absorption of Plant Sterols : Comparison with Wistar Rats
- Increased Monocytic Adhesion by Senescence in Human Umbilical Vein Endothelial Cells
- Slow Absorption of Conjugated Linoleic Acid in Rat Intestines, and Similar Absorption Rates of 9c,11t-Conjugated Linoleic Acid and 10t,12c-Conjugated Linoleic Acid
- Phosphorylation of inositol 1,4,5-triphosphate receptor 1 during in vitro maturation of porcine oocytes
- Factors Affecting Fertilization and Embryonic Development During Intracytoplasmic Sperm Injection in Pigs
- Possible involvement of phosphatidylinositol 3-kinase in the maintenance of metaphase II attest in porcine oocytes matured in vitro
- The change in conjugated linoleic acid concentration in blood of Japanese fed a conjugated linoleic acid diet
- Increased Monocytic Adhesion by Senescence in Human Umbilical Vein Endothelial Cells
- Jacaric Acid, a Linolenic Acid Isomer with a Conjugated Triene System, Reduces Stearoyl-CoA Desaturase Expression in Liver of Mice
- Effect of Dietary Linoleic, α-Linolenic and Arachidonic Acids on Lipid Metabolism, Tissue Fatty Acid Composition and Eicosanoid Production in Rats
- Increased Lipid Accumulation in Liver and White Adipose Tissue in Aging in the SAMP 10 Mouse
- Effect of a Liver X Receptor Agonist on Deposition and Lymphatic Absorption of Plant Sterols in Stroke-Prone Spontaneously Hypertensive Rats Having a Mutation in ATP-Binding Cassette Transporter G5
- High Developmental Rates of Mouse Oocytes Cryopreserved by an Optimized Vitrification Protocol : The Effects of Cryoprotectants, Calcium and Cumulus Cells
- SHRSP/Izm and WKY/NCrlCrlj Rats Having a Missense Mutation in Abcg5 Deposited Plant Sterols in the Body, but Did Not Change Their Biliary Secretion and Lymphatic Absorption—Comparison with Jcl:Wistar and WKY/Izm Rats
- The Change in Conjugated Linoleic Acid Concentration in Blood of Japanese Fed a Conjugated Linoleic Acid Diet
- SHRSP/Izm and WKY/NCrlCrlj Rats Having a Missense Mutation in Abcg5 Deposited Plant Sterols in the Body, but Did Not Change Their Biliary Secretion and Lymphatic Absorption-Comparison with Jcl : Wistar and WKY/Izm Rats
- Successful Production of Offspring Using Cryopreserved Sperm via Nonsurgical Artificial Insemination in Rats
- Dietary Fats Modulate Age-Dependent Effects of Dietary Proteins on Cholesterol Metabolism in Rats
- Effects of Dietary Short-Necked Clam, Tapes japonica, on Serum and Liver Cholesterol Levels in Mice.
- Lymphatic Transport of Stearic Acid and Its Effect on Cholesterol Transport in Rats.
- Dietary Cholesterol Influences on Various Lipid Indices and Eicosanoid Production in Rats Fed Dietary Fat Desirable for the Protection of Ischemic Heart Disease.
- Effects of Heat-Killed Lactobacillus pentosus S-PT84 on Postprandial Hypertriacylglycerolemia in Rats