Dietary Cholesterol Influences on Various Lipid Indices and Eicosanoid Production in Rats Fed Dietary Fat Desirable for the Protection of Ischemic Heart Disease.
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概要
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Young male Sprague-Dawley rats were fed diets containing 10% fat with P/S and n-6/n-3 ratios of 1.2 and 5.0, respectively, and differing levels of dietary cholesterol (0.05 to 1.0% by weight) for 3 weeks, following which the tissue lipid concentration, fatty acid composition, desaturation of linoleic acid, and eicosanoid production were examined. The composition of dietary fat was that recommended for the prevention of atherosclerosis. Dietary cholesterol did not largely influence the concentration of serum cholesterol, but it markedly increased liver cholesterol in a dose-depended manner. The Δ6-desaturase activity in liver microsomes, linoleate desaturation index in liver phosphatidylcholine, and the production of prostaglandin by the aorta and thromboxane A2 by platelets all decreased to a similar extent in relation to dietary cholesterol above 0.2%. Thus, dietary cholesterol influenced various lipid parameters characteristically even when dietary fat with a fatty acid composition desirable for the prevention of atherosclerosis was consumed simultaneously. The dietary cholesterol level of 0.2% was the point of maximum influence in rats upon the indices examined.
- 財団法人 学会誌刊行センターの論文
著者
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Sugano Michihiro
Laboratory Of Food Chemistry Division Of Bioresource And Bioenvironmental Sciences Graduate School K
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LEE Joon
Laboratory of Nutrition Chemistry, Kyushu University School of Agriculture
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Lee Joon
Laboratory Of Nutrition Chemistry Kyushu University School Of Agriculture:(present Office)college Of
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Ikeda Ikuo
Laboratory Of Food And Biomolecular Science Department Of Food Function And Health Division Of Biosc
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