Dietary Protein-dependent Changes in Rat Intestinal 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Activity(Food & Nutrition)

概要

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The effects of dietary protein on intestinal 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase were studied in rats. When the rats' diet was changed from a commercial non-purified diet to a purified diet containing either soybean protein or casein as a protein source, the reductase activity in the jejunum increased progressively while that in the ileum decreased. The extent of the change in the jejunal activity was prominent in rats fed soybean protein. When rats were given a purified diet containing casein for 8 days then a purified diet containing soybean protein, the enzyme activity increased progressively both in the jejunum and ileum. The protein-dependent change became apparent within 1 to 3 days. Among the various animal (sardine and lactalbumin) and vegetable (soybean and wheat gluten) proteins tested, soybean protein was the one that had a specific effect on the intestinal reductase. The contents of mucosal cholesterol was essentially the same except for a slight higher level for the ileum from rats fed lactalbumin. The concentration of serum cholesterol were lower in rats fed vegetable proteins, while the hepatic cholesterol-lowering action of dietary protein was evident only with soybean protein.
社団法人日本農芸化学会の論文
1986-06-23