Effects of Mold Oil Containing γ-Linolenic Acid on the Blood Cholesterol and Eicosanoid Levels in Rats(Food & Nutrition)
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概要
- 論文の詳細を見る
The oil produced by the mold Mortierella ramanniana var. angulispora IFO 8187, containing approximately 6% of γ-linolenic acid (GLA) and 10% linoleic acid (LA), was examined for its effects on blood cholesterol and eicosanoid levels in rats. When rats were fed cholesterol-enriched diets containing 10% fats, the hypocholesterolemic activity of the mold oil was comparable with that of safflower oil containing 75% LA and was significantly greater than in palm olein containing 16% LA. That the hypocholesterolemic effect could be ascribed exclusively to GLA was confirmed by comparing the effects of ethyl-GLA prepared from the mold oil and ethyl-LA. In rats fed the mold oil the aortic production of PGI_2 tended to be higher, whereas the level of plasma TXB_2 was similar to or lower than those in rats fed safflower oil. The specific activity of Δ^6-desaturase in liver microsomes was significantly higher and the ratio of arachidonate/linoleate in liver phosphatidylcholine was much higher in the mold oil than in safflower oil. These results are indicative of the specific function of the Mortierella oil in the regulation of eicosanoid production as well as cholesterol metabolism.
- 社団法人日本農芸化学会の論文
- 1986-10-23
著者
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TANAKA Kazunari
Laboratory of Nutrition, Nagasaki Prefectural Women's Junior College
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SUGANO Michihiro
Laboratory of Food Chemistry, Department of Food Science and Technology, Faculty of Agriculture (46-
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Sugano Michihiro
Laboratory Of Food Chemistry Division Of Bioresource And Bioenvironmental Sciences Graduate School K
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Sugano Michihiro
Laboratory Of Nutrition Chemistry Kyushu University School Of Agriculture
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YOSHIDA Katsuko
Laboratory of Nutrition Chemistry, Kyushu University School of Agriculture
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Tanaka K
Research Institute For Food Science Kyoto University:department Of Biochemistry College Of Agricultu
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ISHIDA Takahiro
Laboratory of Nutrition Chemistry, Kyushu University School of Agriculture
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NIWA Motohiro
Brewing Science Laboratory, Kirin Brewery Co., Ltd.
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ARIMA Masahiro
Brewing Science Laboratory, Kirin Brewery Co., Ltd.
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MORITA Akihito
Brewing Science Laboratory, Kirin Brewery Co., Ltd.
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Morita Akihito
Brewing Science Laboratory Kirin Brewery Co. Ltd.
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Niwa Motohiro
Brewing Science Laboratory Kirin Brewery Co. Ltd.
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Arima M
Kobe Univ. Commerce Kobe Jpn
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Tanaka Kazunari
Laboratory Of Genetic Engineering Graduate School Of Life And Environmental Sciences Kyoto Prefectur
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Ishida T
Laboratory Of Nutrition Chemistry Kyushu University School Of Agriculture
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Ishida Takahiro
Laboratory Of Nutrition Chemistry Kyushu University School Of Agriculture
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Yoshida K
Kyushu Univ. School Of Agriculture Fukuoka Jpn
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Yoshida Katsuko
Laboratory Of Nutrition Chemistry Kyushu University School Of Agriculture
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