Validation of an Ion Trap Tandem Mass Spectrometric Analysis of Mulberry 1-Deoxynojirimycin in Human Plasma : Application to Pharmacokinetic Studies
スポンサーリンク
概要
- 論文の詳細を見る
Mulberry 1-deoxynojirimycin (DNJ) is a potent α-glucosidase inhibitor. Although it is useful for the treatment of diabetes, the human absorption and metabolism of DNJ have never been characterized. We developed a method using hydrophilic interaction chromatography coupled with ion trap tandem mass spectrometry, and found that orally administered DNJ was absorbed into the blood and then excreted into the urine.
- 社団法人 日本農芸化学会の論文
- 2008-08-23
著者
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NAKAGAWA Kiyotaka
Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University
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MIYAZAWA Teruo
Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University
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OIKAWA Shinichi
Department of Internal Medicine, Nippon Medical School
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Oikawa Shinichi
Department Of Internal Medicine Nippon Medical School
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Tsuzuki Tsuyoshi
Food & Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University
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Miyazawa Teruo
Biodynamic Chemistry Graduate School Of Life Sci. And Agriculture Tohoku Univ.
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Miyazawa T
Tohoku Univ. Miyagi Jpn
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Miyazawa T
Tohoku Univ. Sendai Jpn
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Miyazawa Teruo
Department Of Food Chemistry Faculty Of Agriculture Tohoku University
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Miyazawa Teruo
Food & Biodynamic Chemistry Laboratory Graduate School Of Life Science And Agriculture Tohoku Un
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Kimura Toshiyuki
National Institute Of Information And Communications Technology
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Kimura Toshiyuki
National Agricultural Res. Center For Tohoku Region
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Kubota Hiroyuki
Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University
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KARIYA Jun
Project M Co., Ltd.
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Nakagawa Kiyotaka
Food & Biodynamic Chemistry Laboratory Graduate School Of Life Science And Agriculture Tohoku Un
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Nakagawa K
Biodynamic Chemistry Graduate School Of Life Sci. And Agriculture Tohoku Univ.
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Miyazawa Teruo
Tohoku Univ.
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Tsuzuki Tsuyoshi
Food And Biomolecular Science Graduate School Of Life Science And Agriculture Tohoku University
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Kariya Jun
Project M Co. Ltd.
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Kubota Hiroyuki
Food And Biodynamic Chemistry Laboratory Graduate School Of Agricultural Science Tohoku University
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Oikawa Shinichi
Department Of Medicine Nippon Medical School
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Tsuduki Tsuyoshi
Laboratory Of Food And Biomolecular Science Graduate School Of Agriculture Tohoku University
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Masuko Tsuyoshi
Department Of Surgery Division Gi And Colorectal Surgery Research Unit Of Biological Regulation And
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Masuko Tsuyoshi
Department Of Surgery Tohoku University Graduate School Of Medicine
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