Validation of an Ion Trap Tandem Mass Spectrometric Analysis of Mulberry 1-Deoxynojirimycin in Human Plasma: Application to Pharmacokinetic Studies
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概要
- 論文の詳細を見る
Mulberry 1-deoxynojirimycin (DNJ) is a potent α-glucosidase inhibitor. Although it is useful for the treatment of diabetes, the human absorption and metabolism of DNJ have never been characterized. We developed a method using hydrophilic interaction chromatography coupled with ion trap tandem mass spectrometry, and found that orally administered DNJ was absorbed into the blood and then excreted into the urine.
- 社団法人 日本農芸化学会の論文
著者
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NAKAGAWA Kiyotaka
Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University
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MIYAZAWA Teruo
Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University
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OIKAWA Shinichi
Department of Internal Medicine, Nippon Medical School
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Tsuzuki Tsuyoshi
Food & Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University
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Kimura Toshiyuki
National Institute Of Information And Communications Technology
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Nakagawa Kiyotaka
Grad. Sch. Agr. Sci. Tohoku Univ.
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Kubota Hiroyuki
Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University
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KARIYA Jun
Project M Co., Ltd.
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