Efflux of Sphingoid Bases by P-Glycoprotein in Human Intestinal Caco-2 Cells

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概要

• 論文の詳細を見る

• The aim of this study was to determine whether sphingoid bases that originated from various dietary sources, such as mammals, plants, and fungi, are substrates for P-glycoprotein in differentiated Caco-2 cells, which are used as a model of intestinal epithelial cells. In Caco-2 cells, the uptake of sphingosine, the most common sphingoid base found in mammals, was significantly higher at physiological temperatures than those of cis/trans-8-sphingenine, trans-4, cis/trans-8-sphingadienine, 9-methyl-trans-4, trans-8-sphingadienine, or sphinganine. Verapamil, a potent P-glycoprotein inhibitor, increased the cellular accumulation of sphingoid bases, except for sphingosine, in a dose-dependent manner. Incubation with 1 μM digoxin for 48 h caused up-regulation of murtidrug-resistance (MDR)1 mRNA and decreased the accumulation of sphingoid bases in Caco-2 cells, except for sphingosine. Thus P-glycoprotein probably contributes to the selective absorption of sphingosine from dietary sphingolipids in the digestive tract.

• 社団法人 日本農芸化学会の論文
• 2004-12-23

著者

• MIYAZAWA Teruo

  Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University

• Tsuzuki Tsuyoshi

  Food & Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University

• Ohnishi Masao

  Department of Food Science, Obihiro University of Agriculture and Veterinary Medicine

• Ohnishi M

  Obihiro Univ. Agriculture And Veterinary Medicine Obihiro Jpn

• Ohnishi Masao

  Dep. Of Agricultural And Life Sci. Obihiro Univ. Of Agriculture And Veterinary Medicine

• Ohnishi M

  Department Of Agricultural And Life Sciences Obihiro University Of Agriculture And Veterinary Medici

• Miyazawa Teruo

  Biodynamic Chemistry Graduate School Of Life Sci. And Agriculture Tohoku Univ.

• Miyazawa T

  Tohoku Univ. Miyagi Jpn

• Miyazawa T

  Tohoku Univ. Sendai Jpn

• Miyazawa Teruo

  Department Of Food Chemistry Faculty Of Agriculture Tohoku University

• Miyazawa Teruo

  Food & Biodynamic Chemistry Laboratory Graduate School Of Life Science And Agriculture Tohoku Un

• Kinoshita Mikio

  Department of Orthodontics, Osaka Dental University

• Nagata Junichi

  Food Function And Labeling Program Inc. Administrative Agency National Inst. Of Health And Nutrition

• Nagata Junichi

  Division Of Food Science Incorporated Administrative Agency National Institute Of Health And Nutriti

• SAITO Morio

  Division of Food Science, The National Institute of Health and Nutrition

• Saito Morio

  Division Of Food Science Incorporated Administrative Agency National Institute Of Health And Nutriti

• Tsuzuki Tsuyoshi

  Food And Biodynamic Chemistry Laboratory Graduate School Of Agricultural Science Tohoku University

• KASHIMA Minoru

  NOF Corporation

• Ohnishi M

  Iwate Univ. Iwate Jpn

• Ohnishi Masao

  Department Of Agricultural And Life Science Obihiro University Of Agriculture And Veterinary Medicin

• HIRATA Takashi

  Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University

• Kojima Michiyuki

  Department Of Bioresource Chemistry Obihiro University Of Agriculture And Veterinary Medicine

• Kondo Maki

  Dept. Cell Biol. Nat. Inst. Basic Biol.

• Miyazawa Teruo

  Tohoku Univ.

• SUGAWARA Tatsuya

  Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University

• Kinoshita Mikio

  Dep. Of Agricultural And Life Sci. Obihiro Univ. Of Agriculture And Veterinary Medicine

• Ohnishi M

  Laboratory Of Applied Bioscience Obihiro University Of Agriculture And Veterinary Medicine

• Sugawara Tatsuya

  Div. Of Applied Biosciences Graduated School Of Agriculture Kyoto Univ.

• Sugawara Tatsuya

  Division Of Applied Biosciences Graduate School Of Agriculture Kyoto University

• Kinoshita Mikio

  Department Of Agricultural And Life Sciences Obihiro University Of Agriculture And Veterinary Medici

• Komai Michio

  Nof Corporation

• Hirata Takashi

  Division Of Applied Biosciences Graduate School Of Agriculture Kyoto University

• Masuko Tsuyoshi

  Department Of Surgery Division Gi And Colorectal Surgery Research Unit Of Biological Regulation And

• Masuko Tsuyoshi

  Department Of Surgery Tohoku University Graduate School Of Medicine

• KINOSHITA Mikio

  Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medicine

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