Anti-Inflammatory Effect of Buckwheat Sprouts in Lipopolysaccharide-Activated Human Colon Cancer Cells and Mice
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概要
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In conducting an in vitro screening of ethanol extracts from various natural foods using a human colon cancer cell line (CoLoTC cells), an extract of buckwheat sprouts (ExtBS) was found to express significant anti-inflammatory activity. The anti-inflammatory activity of ExtBS was confirmed by oral administration of lipopolysaccharide (LPS) to mice. Inflammatory cytokines (interleukin 6 and tumor necrosis factor alpha) were markedly up-regulated in the spleen and liver from LPS-administrated mice, and combinatory treatment with LPS and ExtBS decreased up-regulation of them in both cytokines. Both serum cytokine levels corresponded to their gene expressions in tissues, but no anti-inflammatry effect in mice was observed when ExtBS was treated intraperitoneally. ExtBS oral administration also showed protective activity as to hepatic injury induced by galactosamine/LPS treatment. Based on these data, we suggest that ExtBS contains anti-inflammatory compounds.
- 社団法人 日本農芸化学会の論文
著者
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ISHII SATOSHI
Department of Soil, Water, and Climate, University of Minnesota
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OHBA Kiyoshi
Hokkaido Tokachi Area Regional Food Processing Technology Center
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Ohnishi Masao
Department of Food Science, Obihiro University of Agriculture and Veterinary Medicine
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Kinoshita Mikio
Department of Orthodontics, Osaka Dental University
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TOKUJI Yoshihiko
Department of Animal Science, Obihiro University of Agriculture and Veterinary Medicine
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KATSUMURA Takafumi
Department of Agricultural and Life Sciences, Obihiro University of Agriculture and Veterinary Medic
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SHIOZUKA Chikara
Department of Agricultural and Life Sciences, Obihiro University of Agriculture and Veterinary Medic
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OOYAUCHI Keisuke
Department of Agricultural and Life Sciences, Obihiro University of Agriculture and Veterinary Medic
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KAWASAKI Kunito
Department of Agricultural and Life Sciences, Obihiro University of Agriculture and Veterinary Medic
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TAKIGAWA Shigenobu
National Agricultural Research Center for Hokkaido Region
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FUKUSHIMA Tatsunobu
Yokohama Research Laboratories, Mitsubishi Rayon Co., Ltd.
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KAWAHARA Mika
Hokkaido Tokachi Area Regional Food Processing Technology Center
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