Fat- and Cholesterol-Enriched Diet Feeding Affects Gene Expression Related to Cholesterol Metabolism in Rats
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概要
- 論文の詳細を見る
This study was designed to investigate the effects of a fat- and cholesterol-enriched diet on gene expression related to cholesterol metabolism in rats. Rats were fed a cholesterol-free diet with 50 g/kg corn oil or a fat- and cholesterol-enriched diet containing 5 g/kg cholesterol and 100 g/kg palm oil for 2 weeks. There were no significant differences in food intake, final body weight and liver weight among the groups. The serum total cholesterol and very low-density lipoprotein + intermediate-density lipoprotein + LDL-cholesterol concentrations in the cholesterol-free diet group were significantly lower than those in the fat- and cholesterol-enriched diet group throughout the experimental period. The serum HDL-cholesterol concentration in the fat- and cholesterol-enriched diet group was significantly lower than that in the cholesterol-free diet at week 1, but there was no significant difference between the groups at week 2. There was no significant difference in the serum triglyceride concentration between the groups throughout the experimental period. The hepatic ADD1/SREBP-1c (adipocyte determination differentiation-dependent factor 1/ sterol regulatory element binding protein), PPARγ (peroxisome proliferator-activated receptor), LDL receptor, scavenger receptor class B type 1, and HMG-CoA reductase mRNA levels in the fat- and cholesterol-enriched diet group were significantly lower that those in the cholesterol-free diet group. However, there were no significant differences in the hepatic fatty acid synthase and cholesterol 7α-hydroxylase mRNA levels between the groups. The results of this study demonstrate that ADD1/SREBP-1c and PPARγ are regulated by food fat in the rat liver and that the decline in nuclear ADD1/SREBP-1c and PPARγ upon feeding the fat- and cholesterol-enriched diet may in part explain the decrease in mRNAs encoding enzymes of the cholesterol biosynthetic pathway.
- 日本油化学会の論文
著者
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Han Kyu-ho
農業･食品産業技術総合研究機構北海道農業研究センター 北海道畑輪作研究チーム
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Han Kyu-ho
Department Of The Electronics Engineering The Korea University
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FUKUSHIMA Michihiro
Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medici
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HASHIMOTO Naoto
Department of Upland Agriculture, National Agricultural Research Center for Hokkaido Region (NARCH)
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OHBA Kiyoshi
Hokkaido Tokachi Area Regional Food Processing Technology Center
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SHIMADA Ken-ichiro
Department of Food Science, Obihiro University of Agriculture and Veterinary Medicine
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SEKIKAWA Mitsuo
Department of Food Science, Obihiro University of Agriculture and Veterinary Medicine
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CHIJI Hideyuki
Department of Food Science and Human Nutrition, Faculty of Human Ecology, Fuji Women's College
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TAMURA Akiko
Department of Animal Science, Obihiro University of Agriculture and Veterinary Medicine
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WATANABE Shoko
Department of Animal Science, Obihiro University of Agriculture and Veterinary Medicine
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Ohba Kiyoshi
Hokkaido Tokachi Area Regional Food Processing Technol. Center
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島田 謙一郎
帯広畜産大学畜産科学科
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Shimada Ken-ichiro
Graduate School Of Global Information And Telecommunications Studies Waseda University
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Sekikawa Mitsuo
Department Of Agriculture And Life Science Obihiro University Of Agriculture And Veterinary Medicine
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Chiji Hideyuki
Department Of Agricultural Chemistry Faculty Of Agriculture Hokkaido University
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Shimada Kenichiro
Department Of Food Science Obihiro University Of Agriculture And Veterinary Medicine
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Shimada Ken-ichiro
Department Of Food Science Obihiro University Of Agriculture And Veterinary Medicine
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Watanabe Shoko
Department Of Animal Science Obihiro University Of Agriculture And Veterinary Medicine
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Han Kyu-ho
Department Of Food Science Obihiro University Of Agriculture And Veterinary Medicine
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Hashimoto Naoto
Department Of Radiology Fukushima Medical College
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CHIJI Hideyuki
Department of Food Science and Human Nutrition, Faculty of Human Ecology, Fuji Women′s College
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TAMURA Akiko
Department of Bioresource Science, Obihiro University of Agriculture and Veterinary Medicine
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HAN Kyu-Ho
Department of Animal Science, Obihiro University of Agriculture and Veterinary Medicine
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HAN Kyu-Ho
Department of Bioresource Science, Obihiro University of Agriculture and Veterinary Medicine
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HASHIMOTO Naoto
Department of Animal Science, Obihiro University of Agriculture and Veterinary Medicine
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HASHIMOTO Naoto
Department of Bioresource Science, Obihiro University of Agriculture and Veterinary Medicine
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WATANABE Shoko
Department of Bioresource Science, Obihiro University of Agriculture and Veterinary Medicine
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SHIMADA Ken-ichiro
Department of Animal Science, Obihiro University of Agriculture and Veterinary Medicine
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FUKUSHIMA Michihiro
Department of Bioresource Science, Obihiro University of Agriculture and Veterinary Medicine
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