Hepatoprotective Effects of Purple Potato Extract against D-Galactosamine-Induced Liver Injury in Rats
スポンサーリンク
概要
- 論文の詳細を見る
We investigated the hepatoprotective effect of purple potato extract (PPE) against D-galactosamine (GalN)-induced liver injury in rats. PPE (400 mg) was administered once daily for 8 d, and then GalN (250 mg/kg of body weight) was injected at 22 h before the rats were killed. Serum tumor necrosis factor alpha (TNF-α), lactate dehydrogenase (LDH), alanine aminotransferase (ALT), and asparate aminotranferase (AST) levels increased significantly after injection of GalN, but PPE inhibited GalN-induced alterations in serum TNF-α, LDH, ALT, and AST levels. Hepatic lipid peroxide and glutathione levels in the control + GalN group were higher and lower respectively than those in the control group, and those in the PPE + GalN group did not differ from that in the control group. The lipid peroxide level in hepatic microsomes treated with 2,2′-azobis (2-amidinopropane) dihydrochloride in the PPE group was significantly lower than that in the control group. This suggests that PPE has hepatoprotective effects against GalN-induced hepatotoxicity via inhibition lipid peroxidation and/or inflammation in rats.
- 社団法人 日本農芸化学会の論文
- 2006-06-23
著者
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Nakao Takashi
Memuro Upland Farming Research Station National Agricultural Research Center For Hokkaido Region
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橋本 誠
北海道大学大学院農学研究院
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Han Kyu-ho
農業･食品産業技術総合研究機構北海道農業研究センター 北海道畑輪作研究チーム
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Han Kyu-ho
岩手大学 大学院連合農学研究科
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Han Kyu-ho
Department Of The Electronics Engineering The Korea University
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FUKUSHIMA Michihiro
Department of Agricultural and Life Science, Obihiro University of Agriculture and Veterinary Medici
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NODA Takahiro
Department of Upland Agriculture, National Agricultural Research Center for Hokkaido Region (NARCH)
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HASHIMOTO Naoto
Department of Upland Agriculture, National Agricultural Research Center for Hokkaido Region (NARCH)
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YAMAUCHI Hiroaki
Department of Upland Agriculture, National Agricultural Research Center for Hokkaido Region (NARCH)
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SHIMADA Ken-ichiro
Department of Food Science, Obihiro University of Agriculture and Veterinary Medicine
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SEKIKAWA Mitsuo
Department of Food Science, Obihiro University of Agriculture and Veterinary Medicine
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CHIJI Hideyuki
Department of Food Science and Human Nutrition, Faculty of Human Ecology, Fuji Women's College
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島田 謙一郎
帯広畜産大学畜産科学科
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Shimada Ken-ichiro
Graduate School Of Global Information And Telecommunications Studies Waseda University
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HASHIMOTO Makoto
Department of Dermatology, Asahikawa Medical College
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Sekikawa Mitsuo
Dep. Of Animal Sci. Obihiro Univ. Of Agriculture And Veterinary Medicine
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Sekikawa Mitsuo
Department Of Agriculture And Life Science Obihiro University Of Agriculture And Veterinary Medicine
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Yada H
National Agriculture Res. Center For Hokkaido Region
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TOPPING David
CSIRO Division of Health Sciences and Nutrition
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Chiji Hideyuki
Department Of Food Science And Human Nutrition Faculty Of Human Ecology Fuji Women's College
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Chiji Hideyuki
Department Of Agricultural Chemistry Faculty Of Agriculture Hokkaido University
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Shimada Kenichiro
Department Of Food Science Obihiro University Of Agriculture And Veterinary Medicine
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Yamauchi H
Department Of Upland Agriculture National Agricultural Research Center For Hokkaido Region
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Yamauchi Hiroaki
Department Of Food Science And Technology Faculty Of Agriculture
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Noda Takahiro
Department Of Internal Medicine And Gastrointestinal Endoscopy Saga Medical School
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Shimada Ken-ichiro
Department Of Food Science Obihiro University Of Agriculture And Veterinary Medicine
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Hashimoto Makoto
Department Of Dermatology Asahikawa Medical College
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Hashimoto Makoto
Obihiro Univ. Agriculture And Veterinary Medicine Hokkaido Jpn
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Han Kyu-ho
Department Of Food Science Obihiro University Of Agriculture And Veterinary Medicine
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Hashimoto Naoto
Department Of Upland Agriculture National Agricultural Research Center For Hokkaido Region
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Hashimoto Naoto
Department Of Radiology Fukushima Medical College
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Hashimoto Makoto
Div. Of Applied Sci. Graduate School Of Agriculture Hokkaido Univ.
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Fukushima Michihiro
Department Of Food Science Obihiro University Of Agriculture And Veterinary Medicine
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Sekikawa Mistuo
Department Of Animal And Food Hygiene Obihiro University Of Agriculture And Veterinary Medicine
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Hashimoto Makoto
Department Of Agriculture And Life Science Obihiro University Of Agriculture And Veterinary Medicine
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Hashimoto Makoto
Department Of Agricultural And Life Science Obihiro University Of Agriculture And Veterinary Medicin
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Hashimoto Makoto
Department Of Agricultural And Life Science Obihiro University Of Agriculture And Veterinary Medicin
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Hashimoto Makoto
Department Of Bioresource Science Obihiro University Agriculture
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Hashimoto Makoto
Department Of Biology And Biochemistry University Of Bath:department Of Bioresource Science Obihiro
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Hashimoto Makoto
Department Of Agricultural And Life Science Obihiro University Of Agriculture And Veterinary Medicin
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Noda Takahiro
Department of Anatomy, Jichi Medical School
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HAN Kyu-Ho
Department of Animal Science, Obihiro University of Agriculture and Veterinary Medicine
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HASHIMOTO Naoto
Department of Animal Science, Obihiro University of Agriculture and Veterinary Medicine
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SHIMADA Ken-ichiro
Department of Animal Science, Obihiro University of Agriculture and Veterinary Medicine
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