Quantitative Determination of Click Reaction in the Presence of Glycine Derivatives and in Dilute Solution
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概要
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The click reaction is one of the latest techniques for the functional analysis of bioactive compounds and the analysis makes novel concepts and strategies for medicinal chemistry. N-methylated glycine derivatives have inhibitory activity for the click reaction in direct Cu(I) system because of decrease of Cu(I) concentration. The Cu(I) concentration recovered effectively by sodium ascorbate. Quantitative determination of click reaction at various ligand concentrations revealed that the decrease in reaction yields was observed in a substrate concentration-dependent manner.
著者
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橋本 誠
北海道大学大学院農学研究院
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Hashimoto Makoto
Obihiro Univ. Agriculture And Veterinary Medicine Hokkaido Jpn
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Hashimoto Makoto
Div. Of Applied Sci. Graduate School Of Agriculture Hokkaido Univ.
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Hashimoto Makoto
Department Of Agricultural And Life Science Obihiro University Of Agriculture And Veterinary Medicin
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Hashimoto Makoto
Department Of Agricultural And Life Science Obihiro University Of Agriculture And Veterinary Medicin
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Hashimoto Makoto
Department Of Bioresource Science Obihiro University Agriculture
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Hashimoto Makoto
Department Of Biology And Biochemistry University Of Bath:department Of Bioresource Science Obihiro
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Hashimoto Makoto
Department Of Agricultural And Life Science Obihiro University Of Agriculture And Veterinary Medicin
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