Photoactive ligands probing the sweet taste receptor. Design and synthesis of highly potent diazirinyl D-phenylalanine derivatives
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概要
- 論文の詳細を見る
Some D-Amino acids such as D-tryptophan and D-phenylalanine are well known as naturally-occurring sweeteners. Photoreactive D-phenylalanine derivatives containing trifluoromethyldiazirinyl moiety at 3- or 4-position of phenylalanine, were designed as sweeteners for functional analysis with photoaffinity labeling. The trifluoromethyldiazirinyl D-phenylalanine derivatives were prepared effectively with chemo-enzymatic methods using L-amino acid oxidase and were found to have potent activity toward the human sweet taste receptor.
- 2010-02-01
著者
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橋本 誠
北海道大学大学院農学研究院
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Abe Keiko
Agricultural And Life Sciences Dep. Of Applied Biological Chemistry
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Hashimoto Makoto
Obihiro Univ. Agriculture And Veterinary Medicine Hokkaido Jpn
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Hashimoto Makoto
Div. Of Applied Sci. Graduate School Of Agriculture Hokkaido Univ.
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Misaka Takumi
Dep. Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Univ. Of
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Misaka Takumi
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Abe Keiko
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Hashimoto Makoto
Department Of Agricultural And Life Science Obihiro University Of Agriculture And Veterinary Medicin
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Hashimoto Makoto
Department Of Agricultural And Life Science Obihiro University Of Agriculture And Veterinary Medicin
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Hashimoto Makoto
Department Of Bioresource Science Obihiro University Agriculture
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Hashimoto Makoto
Department Of Biology And Biochemistry University Of Bath:department Of Bioresource Science Obihiro
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Hashimoto Makoto
Department Of Agricultural And Life Science Obihiro University Of Agriculture And Veterinary Medicin
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Koizumi Ayako
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Tanaka Takaharu
Suntory Institute For Bioorganic Research
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Abe Keiko
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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