Simple Deuterium Introduction at α-Position of Carbonyl in Diazirinyl Derivatives for Photoaffinity Labeling
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概要
- 論文の詳細を見る
Post-functional deuterium incorporation into diazirinyl acetophenone derivatives is reported. Treatment of the compounds with sodium hydroxide in CH3OD at rt for 10 min achieved deuterium incorporation at α-position of the carbonyl group without decomposition of diazirinyl ring. Further deuterium can introduce by reduction of benzyl carbonyl with triethylsilane-d-TFA. Straightforward deuterium introduction into diazirinyl derivatives may contribute to the functional analysis of low molecular compounds with diazirine-based photoaffinity labeling.
- 2010-12-31
著者
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橋本 誠
北海道大学大学院農学研究院
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Hashimoto Makoto
Obihiro Univ. Agriculture And Veterinary Medicine Hokkaido Jpn
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Hashimoto Makoto
Div. Of Applied Sci. Graduate School Of Agriculture Hokkaido Univ.
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MURAI Yuta
Division of Applied Science, Graduate School of Agriculture, Hokkaido University
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Hashimoto Makoto
Department Of Agricultural And Life Science Obihiro University Of Agriculture And Veterinary Medicin
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Hashimoto Makoto
Department Of Agricultural And Life Science Obihiro University Of Agriculture And Veterinary Medicin
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Hashimoto Makoto
Department Of Bioresource Science Obihiro University Agriculture
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Hashimoto Makoto
Department Of Biology And Biochemistry University Of Bath:department Of Bioresource Science Obihiro
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Hashimoto Makoto
Department Of Agricultural And Life Science Obihiro University Of Agriculture And Veterinary Medicin
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Murai Yuta
Div. Of Applied Sci. Graduate School Of Agriculture Hokkaido Univ.
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