Simple Synthesis of Deuterium and ^<13>C Labeled Trifluoromethyl Phenyldiazirine Derivatives as Stable Isotope Tags for Mass Spectrometry
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概要
- 論文の詳細を見る
The synthesis of trifluoromethyl diazirine with a stable isotope tag is reported. We found that both Friedel-Crafts acylation and reduction of aryl carbonyl to methylene, using commercially available stable-isotope reagents, were utilized for the synthesis of diazirinyl fatty acid derivatives. The stable isotope labeled diazirine may be valuable for identifying binding sites by mass spectrometry.
- 公益社団法人日本薬学会の論文
- 2004-11-01
著者
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Hatanaka Yasumaru
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Hatanaka Yasumaru
Faculty Of Pharmaceutical Sciences Hokkaido University
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Hashimoto M
Department Of Agricultural And Life Science Obihiro University Of Agriculture And Veterinary Medicin
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Hashimoto Makoto
Department Of Dermatology Asahikawa Medical College
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Hashimoto Makoto
Department Of Agricultural And Life Science Obihiro University Of Agriculture And Veterinary Medicin
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Hatanaka Yasumaru
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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