Anti-allergic activity of Glycopeptide isolated from Perilla frutescens BRITTON

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概要

• 論文の詳細を見る

• シソ(Perilla frutescens B_<RITTON>)葉熱水抽出液から分離精製されたシソ糖ペプチド(Pe-GP,6kDa)の抗アレルギー活性を検討した。Pe-GPは,ラット腹腔内より単離してIgEで感作したマスト細胞において,特異抗原で刺激したときに誘発されるヒスタミン遊離反応を抑制した。同様にPe-GPはconcanavalin A,compound48/80,mastoparan,ionophore A23187などの誘発するヒスタミン遊離反応も抑制した。これらの結果からPe-GPはヒスタミン遊離機構のうちカルシウム動員以降の経路を主として抑えると考えられる。Pe-GPの生体内における抗アレルギー活性は,IgEを静注して受動感作したマウスの耳介浮腫反応により検討した。抗原塗布前にあらかじめ腹腔内に投与しておくと,Pe-GPは5-100mg/mlの範囲で濃度依存的に浮腫を抑制し抗アレルギー活性を示した。Pe-GPの抗アレルギー活性を有する医薬品としての開発が,健康食品と同様,期待される。

• 2001-12-31

著者

• Oka Syuichi

  Human Stress Signal Research Center (hss) National Institute Of Advanced Industrial Science And Tech

• Oka Syuichi

  Institute Of Molecular And Cell Biology National Institute Of Advanced Industrial Science And Techno

• Oka Syuichi

  Institute For Biological Resources And Functions National Institute Of Advanced Industrial Science A

• TERASAWA Katsutoshi

  Faculty of Medicine, Toyama Medical and Pharmaceutical University

• AKIYAMA Hiroshi

  Division of Food, National Institute of Health Sciences

• HATANAKA YASUMARU

  Faculty of Pharmaceutical Sciences, Hokkaido University

• Hatanaka Yasumaru

  University Of Toyama

• Hatanaka Yasumaru

  Faculty Of Pharmaceutical Sciences Hokkaido University

• Hatanaka Y

  University Of Toyama

• SADAKANE Yutaka

  Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

• NAKAGOMI Kazuya

  Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

• TANIMURA Takenori

  Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

• TAKAGI Shinobu

  Faculgy of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

• FUKUMORI Yasunori

  Hokuren Federation of Agricultural Cooperatives

• Takagi Shinobu

  Faculgy Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University:institute Of Molecul

• Sadakane Yutaka

  Faculty Of Pharmaceutical Sciences Kyushu University Of Health And Welfare

• Nakagomi K

  Department Of Analytical Chemistry School Of Pharmaceutical Sciences Teikyo University

• Nakagomi Kazuya

  Faculty Of Pharmaceutical Sciences Teikyo University

• Tanimura Takenori

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• Akiyama Hiroshi

  Division Of Foods National Institute Of Health Sciences

• Terasawa Katsutoshi

  Faculty Of Medicine Toyama Medical And Pharmaceutical University

• Sadakane Y

  Department Of Analytical Chemistry School Of Pharmaceutical Sciences Kyushu University Of Health And

• Nakagomi Kazuya

  Department Of Analytical Chemistry School Of Pharmaceutical Sciences Teikyo University

• Hatanaka Y

  Toyama Medical And Pharmaceutical Univ. Toyama Jpn

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