Zinc Neurotoxicity and its Role in Neurodegenerative Diseases

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概要

• 論文の詳細を見る

• Zinc is an extremely most abundant trace element in the brain. Substantial amounts of zinc exist in the presynaptic vesicles, and are released with glutamate during the neuronal excitation. Synaptically-released zinc is believed to play crucial roles in normal brain functions. Therefore, zinc deficiency impairs brain development and capabilities of learning and memory. Notwithstanding, recent studies have indicated that excess zinc is linked with several neurodegenerative diseases and has a causative role in delayed neuronal death after transient global ischemia. We have developed the sensitive assay system for zinc neurotoxicity in vitro using GT1-7 cells (immortalized hypothalamic neurons) to elucidate the functions of zinc in neurodegenerative diseases. Pharmacological experiments have exhibited the involvement of energy failure, metal-metal interaction, and disruption of calcium homeostasis in zincinduced neurotoxicity. It is inferred that zinc might play its part in brain functions as Janus, an ancient Roman god with two faces, and that zinc homeostasis is essential for the neuronal survival. Our assay system provides a good method for screening the protective substances of zinc neurotoxicity as a therapeutic target of the global ischemia.

• 公益社団法人日本薬学会の論文
• 2006-02-01

著者

• SADAKANE Yutaka

  Department of Analytical Chemistry, School of Pharmaceutical Sciences, Kyushu University of Health a

• Kawahara Masahiro

  Department Of Chemistry And Biotechnology School Of Engineering

• Kawahara Masahiro

  Department Of Analytical Chemistry Faculty Of Pharmaceutical Sciences The University Of Tokyo

• Konoha Keiko

  Department Of Analytical Chemistry School Of Pharmaceutical Sciences Kyushu University Of Health And

• Sadakane Y

  Department Of Analytical Chemistry School Of Pharmaceutical Sciences Kyushu University Of Health And

• Kawahara Masahiro

  Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo

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