Absent or Extremely Low Neutrophil Alkaline Phosphatase Activity Levels in Patients with Myelodysplastic Syndromes
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概要
- 論文の詳細を見る
Three patients with myelodysplastic syndrome (MDS) had absent or extremely low levels of neutrophil alkaline phosphatase (NAP) activity (arbitrarily defined as an NAP score <10). All patients showed varying degrees of hypogranulation in neutrophil morphology. The NAP activity levels transiently normalized following the administration of granulocyte colony-stimulating factor (G-CSF) in two cases. No patients experienced any severe infectious episodes. These results suggest that NAP activity is not central to the neutrophil function.
- 社団法人 日本内科学会の論文
著者
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Kawahara Masahiro
Department Of Analytical Chemistry Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Yoshinaga Noriyoshi
Department Of Hematology And Oncology Graduate School Of Medicine Kyoto University
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Oguma Shigeru
The Center For Hematological Diseases Takeda General Hospital
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Yoshida Yataro
The Center For Hematological Diseases Takeda General Hospital
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Katsurada Tatsuya
The Center For Hematological Diseases Takeda General Hospital
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Kawabata Hiroshi
Department of Electronic Science and Engineering, Kyoto University, Kyoto 606-8501, Japan
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Nakabo Yukiharu
The Center for Hematological Diseases, Takeda General Hospital, Japan
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Kawahara Masahiro
Department of Hematology/Oncology, Graduate School of Medicine, Kyoto University, Japan
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Yoshinaga Noriyoshi
Department of Hematology/Oncology, Graduate School of Medicine, Kyoto University, Japan
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Yoshida Yataro
The Center for Hematological Diseases, Takeda General Hospital, Japan
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Kawabata Hiroshi
Department of Hematology/Oncology, Graduate School of Medicine, Kyoto University, Japan
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