Successful Treatment of a Patient with Multicentric Castleman's Disease who Presented with Thrombocytopenia, Ascites, Renal Failure and Myelofibrosis Using Tocilizumab, an Anti-Interleukin-6 Receptor Antibody
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概要
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We herein describe an unusual case of multicentric Castleman's disease accompanied by thrombocytopenia, ascites, renal failure and myelofibrosis in a Japanese woman. The patient was initially diagnosed as having myelodysplastic syndrome with myelofibrosis. The general condition of the patient deteriorated rapidly; however, treatment with tocilizumab, an anti-interleukin-6 receptor antibody, together with corticosteroids dramatically improved her symptoms. The clinical features of this case were similar to those of three cases previously reported by Takai et al. (Rinsho Ketsueki, 2010, 51:320-5), which were determined to be thrombocytopenia, anasarca, fever, reticulin myelofibrosis and organomegaly (TAFRO) syndrome, a possibly distinct clinical entity.
著者
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Takaori-kondo Akifumi
Department Of Hematology And Oncology Graduate School Of Medicine Kyoto University
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MATSUMURA Yumi
Department of Dermatology Graduate School of Medicine Kyoto University
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KATSURADA Tatsuya
Department of Hematology, Takeda General Hospital
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Kadowaki Norimitsu
Department Of Hematology And Oncology Graduate School Of Medicine Kyoto University
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Kondo Tadakazu
Department Of Hematology And Oncology Graduate School Of Medicine Kyoto University
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Kotani Shin-ichi
Department Of Hematology And Oncology Kyoto University Hospital
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Kawabata Hiroshi
Department of Electronic Science and Engineering, Kyoto University, Kyoto 606-8501, Japan
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Haga Hironori
Department of Diagnostic Pathology Graduate School of Medicine, Kyoto University
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