Immune Pancytopenia Associated with a Leukemic B-Cell Tumor Carrying t(14;18)(q32;q21) Translocation
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概要
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We report a 75-year-old man who was initially suggested to have acute leukemia. The hemoglobin level was 3.8 g/dL, white cell count was 7,700/μL with an absence of mature neutrophils and 69.0% leukemic cells, and platelet was 0.4×104/μL. Coombs antiglobulin test was positive. Leukemic cells were CD5-, CD10+, CD20+, CD23-, and IgG/λdim+. The bone marrow consisted of normal hematopoietic precursors, whereas fluorescence in situ hybridization detected the BCL2/IgH fusion gene. He was treated with rituximab-containing chemotherapy, resulting in the resolution of pancytopenia. The underlying disease was a leukemic B-cell tumor with t(14;18)(q32;q21), and the pancytopenia was mainly caused by autoimmune mechanisms.
著者
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Oguma Shigeru
Department Of Hematology And Oncology Graduate School Of Medicine Kyoto University
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Mizumoto Chisaki
Department Of Hematology And Oncology Graduate School Of Medicine Kyoto University
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KATSURADA Tatsuya
Department of Hematology, Takeda General Hospital
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Yoshida Yataro
Department Of Gynecology And Obstetrics And Blood Transfusion Service Faculty Of Medicine. Kyoto Uni
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Ohno Hitoshi
Department Of Hematology And Oncology Clinical Sciences For Pathological Organs Graduate School Of M
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Yoshida Yataro
Department of Hematology, Takeda General Hospital, Japan
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Mizumoto Chisaki
Department of Hematology, Takeda General Hospital, Japan
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