Immune Pancytopenia Associated with a Leukemic B-Cell Tumor Carrying t(14;18)(q32;q21) Translocation

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概要

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• We report a 75-year-old man who was initially suggested to have acute leukemia. The hemoglobin level was 3.8 g/dL, white cell count was 7,700/μL with an absence of mature neutrophils and 69.0% leukemic cells, and platelet was 0.4×104/μL. Coombs antiglobulin test was positive. Leukemic cells were CD5-, CD10+, CD20+, CD23-, and IgG/λdim+. The bone marrow consisted of normal hematopoietic precursors, whereas fluorescence in situ hybridization detected the BCL2/IgH fusion gene. He was treated with rituximab-containing chemotherapy, resulting in the resolution of pancytopenia. The underlying disease was a leukemic B-cell tumor with t(14;18)(q32;q21), and the pancytopenia was mainly caused by autoimmune mechanisms.

著者

• Oguma Shigeru

  Department Of Hematology And Oncology Graduate School Of Medicine Kyoto University

• Mizumoto Chisaki

  Department Of Hematology And Oncology Graduate School Of Medicine Kyoto University

• KATSURADA Tatsuya

  Department of Hematology, Takeda General Hospital

• Yoshida Yataro

  Department Of Gynecology And Obstetrics And Blood Transfusion Service Faculty Of Medicine. Kyoto Uni

• Ohno Hitoshi

  Department Of Hematology And Oncology Clinical Sciences For Pathological Organs Graduate School Of M

• Yoshida Yataro

  Department of Hematology, Takeda General Hospital, Japan

• Mizumoto Chisaki

  Department of Hematology, Takeda General Hospital, Japan

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