t(11;18)(q21;q21)-positive Advanced-stage MALT Lymphoma Associated with Monoclonal Gammopathy : Resistance to Rituximab or Rituximab-containing Chemotherapy
スポンサーリンク
概要
- 論文の詳細を見る
Here we describe two cases of mucosa-associated lymphoid tissue (MALT) lymphoma with monoclonal immunoglobulins (Igs). The first case was a 77-year-old man with primary lymphoma of the lung. Immunoelectrophoresis detected IgM-κ in serum and κ light chain excretion into urine. Three months after treatment with single-agent rituximab, a large amount of pleural fluid was found to have accumulated. The fluid contained CD5-, CD10-, CD19+, CD38+ and CD138-/+ lymphoma cells with lymphoplasmacytoid appearance. Although a small fraction of the cells were CD20+, the majority of the lymphoma cells were negative and expressed surface-membrane IgM-κ at low levels. The cells possessed a karyotype of 46, XY, t(11;18)(q21;q21). The second case was a 55-year-old man who underwent total gastrectomy due to gastric perforation. Surgical specimens demonstrated the histopathological features of MALT lymphoma associated with plasma cell differentiation. The lymphoma cells had a 46, XY, t(11;18)(q21;q21) karyotype. Monoclonal Igs detected were serum IgA (M)-κ and urinary κ light chain. The patient was subsequently treated with six cycles of R-CVP (rituximab, cyclophosphamide, vincristine and prednisolone) ; however, serum monoclonal Ig levels were not affected. The lymphoma cells in both cases may have contained two populations, a rituximab-sensitive CD20+ population and a rituximab-resistant population that had differentiated into the Ig-secreting plasma cell stage. [J Clin Exp Hematopathol 48(2) : 47-54, 2008]
- 2008-11-01
著者
-
Isoda Kotaro
Kyoto Byori
-
OHNO Hitoshi
Department of Hematology, Takeda General Hospital
-
Ohno Hitoshi
Department Of Hematology And Oncology Graduate School Of Medicine Kyoto University
-
Ohno Hitoshi
Department Of Hematology And Oncology Clinical Sciences For Pathological Organs Graduate School Of M
関連論文
- Coexistence of Mucosa-associated Lymphoid Tissue Lymphoma with Plasma Cell Features and Adenocarcinoma Cells in Pleural Fluid
- t(11;18)(q21;q21)-positive Advanced-stage MALT Lymphoma Associated with Monoclonal Gammopathy : Resistance to Rituximab or Rituximab-containing Chemotherapy
- Epstein-Barr virus-positive diffuse large B-cell lymphoma carrying a t(9;14)(p13;q32) translocation
- Gallium-67 demonstration of extensive soft-tissue involvement of multiple myeloma
- Extraosseous accumulation of ^Tc-MDP in lymph node metastases of small cell carcinoma of the esophagus
- Epstein-Barr virus-associated T-cell lymphoma in an adult patient : prominent infiltrates within the liver portal area revealed by autopsy
- Relationship between ^Tc-GSA scintigraphic indices of liver function reserve and portal circulation in patients with chronic liver disease
- Arteriovenous malformation of the gallbladder : CT and angiographic findings
- Successful Allogeneic Bone Marrow Transplantation for Acute Myelogenous Leukemia after Drug-Induced Cardiomyopathy
- Numerous aggregates of "tiny" micromegakaryocytes in the bone marrow
- Polyclonal Proliferation of Plasma Cells Associated with Marked Hypergammaglobulinemia in an Elderly Patient
- Reappraisal of BCL3 as a Molecular Marker of Anaplastic Large Cell Lymphoma
- Immune Pancytopenia Associated with a Leukemic B-Cell Tumor Carrying t(14;18)(q32;q21) Translocation
- Comparison of gene expression profiles of lymphoma cell lines from transformed follicular lymphoma, Burkitt's lymphoma and de novo diffuse large B-cell lymphoma
- Synchronous presentation of Epstein-Barr virus-associated Hodgkin's disease and adult T-cell leukemia/lymphoma (ATLL) in a patient from an endemic area of ATLL
- Class switch recombination of the immunoglobulin heavy chain gene frequently occurs in B-cell lymphomas associated with rearrangement of the BCL2 gene
- Rituximab alone was effective for the treatment of a diffuse large B-cell lymphoma associated with hemophagocytic syndrome
- Erythropoientin-Producing Renal Cell Carcinoma Arising from Acquired Cystic Disease of the Kidney
- Coexistent Rearrangements of c-MYC, BCL2, and BCL6 Genes in a Diffuse Large B-Cell Lymphoma
- The duration of functioning of a subcutaneous implantable port for the treatment of hematological tumors : a single institution-based study
- Three Approaches for Laparoscopic Unroofing of Simple and Complicated Renal Cysts
- Laparoscopic Marsupialization of a Symptomatic Simple Renal Cyst : A Case Report
- Spontaneous recovery from renal infarction resulting from renal artery dissection
- A contact investigation of the transmission of Mycobacterium tuberculosis from a nurse working in a newborn nursery and maternity ward
- Phase II study of ABVd therapy for newly diagnosed clinical stage II-IV Hodgkin lymphoma : Japan Clinical Oncology Group study (JCOG 9305)
- Pathogenetic and Clinical Implications of Non-Immunoglobulin ; BCL6 Translocations in B-Cell Non-Hodgkin's Lymphoma
- Double-Hit Lymphoma with t(8;14)(q24;q32) and t(12;14)(q24;q32) Chromosomal Translocations
- Applicability of LCS to the laparoscopic varicocelectomy
- Angioimmunoblastic T-Cell Lymphoma Initially Presenting with Replacement of Bone Marrow and Peripheral Plasmacytosis
- Outbreak of pandemic 2009 influenza A/H1N1 infection in the hematology ward : fatal clinical outcome of hematopoietic stem cell transplant recipients and emergence of the H275Y neuraminidase mutation
- Short- and long-term effects of rituximab for the treatment of thrombotic thrombocytopenic purpura : four case reports
- Histopathology of Bone Marrow "Clot" Section of a Mantle Cell Lymphoma
- Intravascular Large B-Cell Lymphoma Associated with t(14;19)(q32;q13) Translocation
- Association of Primary Myeloperoxidase Deficiency and Myeloproliferative Neoplasm
- Observer variation study of the assessment and diagnosis of incidental colonic FDG uptake