Angioimmunoblastic T-Cell Lymphoma Initially Presenting with Replacement of Bone Marrow and Peripheral Plasmacytosis
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概要
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A 73-year-old man presented with lymphadenopathy, hepatosplenomegaly, and a variety of hematological and immunological abnormalities. The bone marrow was replaced by polymorphic cellular infiltrates containing aggregates of CD10+ T-cells. Circulating lymphoplasmacytic/immunoblastic cells showed an early plasma cell immunophenotype on flow cytometric analysis. Combination of these observations indicated that the underlying disorder of this patient was angioimmunoblastic T-cell lymphoma (AITL); postmortem pathology was consistent with progression of peripheral T-cell lymphoma. Even in the absence of definitive lymph node biopsy, the appearance of the bone marrow and the peripheral blood can lead to the diagnosis of AITL.
著者
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Okamoto Eiichi
Department of Medicine and Biological Science
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KATSURADA Tatsuya
Department of Hematology, Takeda General Hospital
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Yoshida Yataro
Department Of Gynecology And Obstetrics And Blood Transfusion Service Faculty Of Medicine. Kyoto Uni
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Sakai Hisashi
Department Of Electric Engineering Hiroshima Denki Institute Of Technology
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Ohno Hitoshi
Department Of Hematology And Oncology Clinical Sciences For Pathological Organs Graduate School Of M
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Tanaka Hideaki
Department Of Applied Chemistry & Biochemistry Faculty Of Engineering Kumamoto University
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