A Short Peptide GPIGS Promotes Proliferation of Hair Bulb Keratinocytes and Accelerates Hair Regrowth in Mice(Pharmacology)
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概要
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The aim of this study was to discover a novel agent that promotes hair growth. We carried out a screening test in 298 types of conditioned medium (CM) from cultures of bacteria by using a hair bulb keratinocyte (HBK) growth assay. As a result, we found a HBK growth factor in the CM of Bacillus sp. M18. This HBK growth factor was purified by collecting biologically active fractions in three steps, including HP-20 batch processing, LH-20 chromatography and C_<18> reverse-phase high-pressure liquid chromatography, and identified as a short peptide GPIGS. GPIGS increased Akt phosphorylation in HBKs. Moreover, the GPIGS-stimulated HBK growth was inhibited by the treatment with LY294002, an inhibitor of phosphatidylinositol 3-kinase (PI-3K). These results suggest that GPIGS promotes HBK growth via the PI-3K/Akt pathway. In addition to in vitro tests, GPIGS was found to accelerate hair regrowth in telogen mice. Our results indicate that GPIGS is a potential agent to promote hair growth.
- 公益社団法人日本薬学会の論文
- 2005-03-01
著者
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Oka Syuichi
Institute Of Molecular And Cell Biology National Institute Of Advanced Industrial Science And Techno
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Oka Syuichi
Institute For Biological Resources And Functions National Institute Of Advanced Industrial Science A
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MAEKAWA Takaaki
Institute of Agricultural and Forest Engineering, University of Tsukuba
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Maekawa Takaaki
Institute Of Agricultural And Forest Engineering Food And Bioresource Process Engineering Laboratory
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Kawano Yasuhiro
Institute For Biological Resources And Functions National Institute Of Advanced Industrial Science A
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TSURUDA Akinori
Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science
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Tsuruda Akinori
Institute For Biological Resources And Functions National Institute Of Advanced Industrial Science A
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