Application of Supermex System to Screen Behavioral Traits Produced by Tributyltin in the Rat
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概要
- 論文の詳細を見る
It has been unknown whether or not endocrine disruptors exert their effects on neuronal functions, particularly leading to behavioral alterations. To address this hypothesis, we applied the Supermex system that detects the radiated body heat of an animal, representing the spontaneous motor activity of it. Intracisteral administration of tributyltin, an endocrine disruptor, into 5-day-old Wistar rats caused hyperactivity at 4-5 weeks of age. It was about 1.4 fold more hyperactive than vehicle-treated rats in the dark phase, but not in the light phase. Thus, it might be possible to apply the Supermex system to screen the behavioral deficits produced by other endocrine disruptors.
- 公益社団法人日本薬学会の論文
- 2002-10-01
著者
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Kunimoto Manabu
Department of Public Health, School of Pharmaceutical Sciences, Kitasato University
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Oka Syuichi
Human Stress Signal Research Center (hss) National Institute Of Advanced Industrial Science And Tech
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Oka Syuichi
Institute Of Molecular And Cell Biology National Institute Of Advanced Industrial Science And Techno
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MORITA Masatoshi
Endocrine Disrupters Research Laboratory, National Institute for Environmental Studies
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Morita M
National Inst. Environmental Studies Tsukuba
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Morita M
Endocrine Disruptors And Dioxin Research Projects National Institute For Environmental Studies
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Kunimoto Manabu
National Institute For Environmental Studies:department Of Public Health School Of Pharmaceutical Sc
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Kunimoto Manabu
The National Institute For Environmental Studies Tsukuba
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Kunimoto Manabu
Department Of Public Health School Of Pharmaceutical Sciences Kitasato University
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Morita Masatoshi
Endocrine Disrupters Research Laboratory National Institute For Environmental Studies
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Kunimoto M
National Institute For Environmental Studies:department Of Public Health School Of Pharmaceutical Sc
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Morita M
Endocrine Disrupters Research Laboratory National Institute For Environmental Studies
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Ishido Masami
Endocrine Disruptors and Dioxin Research Projects, National Institute for Environmental Studies
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Masuo Yoshinori
International Patent Organism Depositary National Institute of Advanced Industrial Science and Techn
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Oka Syuichi
International Patent Organism Depositary National Institute of Advanced Industrial Science and Techn
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Masuo Yoshinori
Human Stress Signal Research Center (hss) National Institute Of Advanced Industrial Science And Tech
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Ishido M
Environmental Risk Res Program National Inst. For Environmental Studies
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Morita Masatoshi
Endocrine Disrupter Research Laboratory National Institute For Environmental Studies
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