Application of Supermex System to Screen Behavioral Traits Produced by Tributyltin in the Rat

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概要

• 論文の詳細を見る

• It has been unknown whether or not endocrine disruptors exert their effects on neuronal functions, particularly leading to behavioral alterations. To address this hypothesis, we applied the Supermex system that detects the radiated body heat of an animal, representing the spontaneous motor activity of it. Intracisteral administration of tributyltin, an endocrine disruptor, into 5-day-old Wistar rats caused hyperactivity at 4-5 weeks of age. It was about 1.4 fold more hyperactive than vehicle-treated rats in the dark phase, but not in the light phase. Thus, it might be possible to apply the Supermex system to screen the behavioral deficits produced by other endocrine disruptors.

• 公益社団法人日本薬学会の論文
• 2002-10-01

著者

• Kunimoto Manabu

  Department of Public Health, School of Pharmaceutical Sciences, Kitasato University

• Oka Syuichi

  Human Stress Signal Research Center (hss) National Institute Of Advanced Industrial Science And Tech

• Oka Syuichi

  Institute Of Molecular And Cell Biology National Institute Of Advanced Industrial Science And Techno

• MORITA Masatoshi

  Endocrine Disrupters Research Laboratory, National Institute for Environmental Studies

• Morita M

  National Inst. Environmental Studies Tsukuba

• Morita M

  Endocrine Disruptors And Dioxin Research Projects National Institute For Environmental Studies

• Kunimoto Manabu

  National Institute For Environmental Studies:department Of Public Health School Of Pharmaceutical Sc

• Kunimoto Manabu

  The National Institute For Environmental Studies Tsukuba

• Kunimoto Manabu

  Department Of Public Health School Of Pharmaceutical Sciences Kitasato University

• Morita Masatoshi

  Endocrine Disrupters Research Laboratory National Institute For Environmental Studies

• Kunimoto M

  National Institute For Environmental Studies:department Of Public Health School Of Pharmaceutical Sc

• Morita M

  Endocrine Disrupters Research Laboratory National Institute For Environmental Studies

• Ishido Masami

  Endocrine Disruptors and Dioxin Research Projects, National Institute for Environmental Studies

• Masuo Yoshinori

  International Patent Organism Depositary National Institute of Advanced Industrial Science and Techn

• Oka Syuichi

  International Patent Organism Depositary National Institute of Advanced Industrial Science and Techn

• Masuo Yoshinori

  Human Stress Signal Research Center (hss) National Institute Of Advanced Industrial Science And Tech

• Ishido M

  Environmental Risk Res Program National Inst. For Environmental Studies

• Morita Masatoshi

  Endocrine Disrupter Research Laboratory National Institute For Environmental Studies

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