Effect of Dominant-Negative Expression of L1 Cytoplasmic Domain on the Localization of Brain Ankyrins in Human Neuroblastoma NB-1 Cells
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概要
- 論文の詳細を見る
Two isoforms of brain ankyrin, 440 kD and 220 kD ankyrin_B, and neuronal cell adhesion molecule L1, which can bind to brain ankyrin, are both expressed in human neuroblastoma NB-1 cells. To examine the potential importance of the interaction between brain ankyrins and L1 in neuronal cell functions, an expression vector encoding a cytoplasmic domain of L1 has been constructed and transfected in NB-1 cells. The results obtained show that the expressed L1 cytoplasmic domain is ineffective in perturbing the interaction between brain ankyrins and L1, possibly because it exists in a monomeric form.
- 公益社団法人日本薬学会の論文
- 2001-12-01
著者
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Han Jin-yi
Regional Environment Division National Institute For Environmental Studies:(present Address)college
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Adachi Tatsumi
National Institute For Environmental Studies:department Of Basic Medical Sciences National Institute
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Adachi Tatsumi
Regional Environment Division National Institute For Environmental Studies:department Of Basic Medic
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Kunimoto Manabu
National Institute For Environmental Studies:department Of Public Health School Of Pharmaceutical Sc
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Kunimoto Manabu
The National Institute For Environmental Studies Tsukuba
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Kunimoto Manabu
Regional Environment Division National Institute For Environmental Studies:department Of Public Heal
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Kunimoto Manabu
Regional Environment Division National Institute For Environmental Studies
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Kunimoto M
National Institute For Environmental Studies:department Of Public Health School Of Pharmaceutical Sc
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Ishido Masami
Regional Environment Division, National Institute for Environmental Studies
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Ishido M
Environmental Risk Res Program National Inst. For Environmental Studies
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Ishido Masami
Regional Environment Division National Institute For Environmental Studies
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