Modulating Effect of Sesamin, a Functional Lignan in Sesame Seeds, on the Transcription Levels of Lipid- and Alcohol-Metabolizing Enzymes in Rat Liver : A DNA Microarray Study
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概要
- 論文の詳細を見る
Sesamin, a major lignan in sesame seeds, has multiple functions such as cholesterol-lowering and anti-hypertensive activities. To investigate the effect of sesamin on gene expression in the liver, a DNA microarray analysis was carried out. The ingestion of sesamin dissolved in olive oil up-regulated the expression of 38 genes, 16 of which encode proteins possessing a lipid-metabolizing function, and 16 of which encode proteins possessing a xenobiotic/endogenous substance metabolizing function. In particular, sesamin significantly increased the expression of β-oxidation-associated enzymes in peroxisomes and auxiliary enzymes required for degradation, via the β-oxidation pathway, of unsaturated fatty acids in mitochondria. The ingestion of sesamin also resulted in an increase in the gene expression of acyl-CoA thioesterase involved in acyl-CoA hydrolase and very-long-chain acyl-CoA thioesterase. Interestingly, it induced the expression of the gene for aldehyde dehydrogenase, an alcohol-metabolizing enzyme. These results suggest that sesamin regulates the metabolism of lipids, xenobiotics, and alcohol at the mRNA level.
- 社団法人 日本農芸化学会の論文
- 2005-01-23
著者
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ABE Keiko
Department of Pathology, Tohoku University Graduate School of Medicine
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Abe Keiko
Agricultural And Life Sciences Dep. Of Applied Biological Chemistry
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Kiso Yoshinobu
Suntory Institute For Health Care Science
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Tsuruoka Nobuo
Suntory Institute For Biomedical Research
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Tsuruoka Nobuo
Suntory Institute For Health Care Science
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MATSUMOTO Ichiro
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The U
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Abe Keiko
Department Of Cardiovascular Physiology And Medicine Graduate School Of Biomedical Sciences Hiroshim
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Kiso Yoshinobu
Suntory Institute For Fundamental Research.
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KIDOKORO Ayako
Suntory Institute for Health Care Science
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Abe Keiko
Graduate School Of Agricultural And Life Sciences Univ. Of Tokyo
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Abe Keiko
Department Of Agricultural Chemistry The University Of Tokyo
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Matsumoto Ichiro
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Matsumoto Ichiro
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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