Cell Culture and Motility Study on a Polymer Surface with a Nanometer-Scaled Stripe Structure
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概要
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We developed a large cell culture surface with a nanostripe structure by paving polydimethylsiloxane (PDMS) replicas of a glass mold. The stripe structure has a height of 180 nm and top width of 500 nm with 400-nm intervals between stripes. Human stomach cancer SH-10-TC cells cultured on the surface changed their morphology to elongated shapes parallel to the nanostripes. In addition, cell motility parallel to the stripes was greatly enhanced. These findings strongly suggest that the nanostripe structure affected the cell physiology.
著者
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ABE Keiko
Department of Pathology, Tohoku University Graduate School of Medicine
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Yoshimura Etsuro
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The U
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TSUKAHARA Takehiko
Department of Applied Chemistry, Graduate School of Engineering, the University of Tokyo
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SATO Kiichi
Department of Applied Chemistry, School of Engineering, The University of Tokyo
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Abo Mitsuru
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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SAKAMOTO Yasuyuki
Department of Applied Biological Chemistry, School of Agricultural and Life Sciences, The University
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KITAMORI Takehiko
Center for NanoBio Integration, The University of Tokyo
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