Up-Regulation of Genes Related to the Ubiquitin-Proteasome System in the Brown Adipose Tissue of 24-h-Fasted Rats

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概要

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• The functional balance between brown adipose tissue (BAT) and white adipose tissue (WAT) is important for metabolic homeostasis. We compared the effects of fasting on the gene expression profiles in BAT, WAT and liver by using a DNA microarray analysis. Tissues were obtained from rats that had been fed or fasted for 24 h. Taking the false discovery rate into account, we extracted the top 1,000 genes that had been differentially expressed between the fed and fasted rats. In all three tissues, a Gene Ontology analysis revealed that the lipid and protein biosynthesis-related genes had been markedly down-regulated. The whole-body fuel shift from glucose to triacylglycerol and the induction of autophagy were also observed. There was marked up-regulation of genes in the ‘protein ubiquitination’ category particularly in BAT of the fasted rats, suggesting that the ubiquitin-proteasome system was involved in saving energy as an adaptation to food shortage.

• 社団法人 日本農芸化学会の論文
• 2008-01-23

著者

• Shimizu Kentaro

  Graduate School Of Agricultural And Life Sciences The University Of Tokyo

• MINAMI Michiko

  Department of Natural and Environmental Science, Faculty of Education, Tokyo Gakugei University

• Kadota Koji

  Dep. Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Univ. Of

• ABE Keiko

  Graduate School of Agricultural and Life Sciences, the University of Tokyo

• Nakai Yuji

  Graduate School Of Natural Science And Technology Kanazawa University

• Kato Hisanori

  Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo

• Minami Michiko

  Department Of Natural And Environmental Science Faculty Of Education Tokyo Gakugei University

• Matsumoto Ichiro

  Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo

• Kato Hisanori

  Graduate School Of Agricultural And Life Sciences The University Of Tokyo

• Kadota Koji

  Graduate School Of Agricultural And Life Sciences The University Of Tokyo

• HASHIDA Hiroko

  Department of Natural and Environmental Science, Faculty of Education, Tokyo Gakugei University

• Hashida Hiroko

  Department Of Natural And Environmental Science Faculty Of Education Tokyo Gakugei University

• Abe Keiko

  Graduate School Of Agricultural And Life Sciences Univ. Of Tokyo

• Nakai Yuji

  Graduate School Of Agricultural And Life Sciences The University Of Tokyo

• Abe Keiko

  Graduate School Of Agricultural And Life Sciences The University Of Tokyo

• Matsumoto Ichiro

  Graduate School Of Agricultural And Life Sciences The University Of Tokyo

• Nakai Yuji

  Graduate School of Agricultural and Life Sciences, The University of Tokyo

• Nakai Yuji

  Graduate School of Agricultural and Life Science, The University of Tokyo

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