Safety Evaluation of Hypoallergenic Wheat Flour by Using a DNA Microarray
スポンサーリンク
概要
- 論文の詳細を見る
The effect of the consumption of hypoallergenic wheat flour (HWF) on the expression of a wide spectrum of genes was analyzed by using a DNA microarray. Gene expression profiles in the liver and intestines of rats fed on a diet composed mainly of HWF were compared with those of rats fed on a normal flour-based diet. Among the eight thousand transcripts represented on the GeneChip microarray, no more than 30 genes exhibited up- or down-regulation of two-fold or more after one week or two months of HWF consumption. No adverse effects were apparent. Up-regulation of some of the genes known to respond to the interferon-γ signal was apparent in the one-week experiment, which may be related to possible oral immunotolerance resulting from HWF feeding. This DNA microarray technology presents an efficient method for evaluating the safety of foods.
- 社団法人 日本農芸化学会の論文
- 2006-06-23
著者
-
MORIYAMA Megumi
Omu milk Products Co., Ltd.
-
Arai Soichi
Department Of Nutritional Science Tokyo University Of Agriculture
-
Abe Keiko
Department Of Cardiovascular Physiology And Medicine Graduate School Of Biomedical Sciences Hiroshim
-
KATO Hisanori
Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo
-
Fu Zhengwei
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
-
Fu Zhengwei
Department Of Applied Biochemistry United Graduate School Tokyo University Of Agriculture And Technl
-
Kato Hisanori
Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo
-
Endo Yoshie
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
-
Arai Soichi
Department Of Agricultural Chemistry Faculty Of Agriculture The University Of Tokyo
-
NARASAKA Sachiko
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The U
-
Narasaka Sachiko
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
-
Moriyama Megumi
Omu Milk Products Co. Ltd. Fukuoka Jpn
-
Moriyama Megumi
Omu Milk Products Co. Ltd.
-
Abe Keiko
Department Of Agricultural Chemistry The University Of Tokyo
-
Abe Keiko
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
-
ARAI Soichi
Department of Agricultural Chemicatry, The University of Tokyo
関連論文
- Preparation of Hypoallergenic Wheat Flour Noodles and Evaluation of Their Physical Properties
- Vascular Ehlers-Danlos syndrome-All three coronary artery spontaneous dissections
- Nifedipine Interferes with Migration of Vascular Smooth Muscle Cells via Inhibition of Pyk2-Src Axis
- PE-127 Role of Src and Cas in Dorsal Ruffling, Lamellipodia and Migration in Vascular Smooth Muscle Cells(PE022,Atherosclerosis, Basic (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Angiotensin II-Induced Osteopontin Expression in Vascular Smooth Muscle Cells Involves G_, Ras, ERK, Src and Ets-1
- PJ-617 Role of HIF-1-dependent Expression of the VLDL Receptor in the Progression of Atherosclerosis(Atherosclerosis, basic(08)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Identification of β and γ Subunits of Laminins Localized in the Basement Membrane of Rat Circumvallate Papillae(Biochemistry & Molecular Biology)
- Changes in Cell Morphology and Cell-to-cell Adhesion Induced by Extracellular Ca^ in Cultured Taste Bud Cells(Biochemistry & Molecular Biology)
- PE-125 DNA Double-Strand Breaks and DNA Repair Enzyme Activity are Increased in Human Atherosclerotic Plaque(Atherosclerosis, basic-6, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-277 DEC1, a Member of the Fifth Clock-Gene Family, is Induced by Angiotensin II, Growth Factors, and Hypoxia in Vascular Cells(Hypertension, basic-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Addition of Signal Leader Sequences to the N-Termini of Olfactory Receptor Proteins Enhances Their Expression in Xenopus Oocyte
- Random Expression of Main and Vomeronasal Olfactory Receptor Genes in Immature and Mature Olfactory Epithelia of Fugu rubripes
- Identification of Taste-Tissue-Specific cDNA Clones from a Subtraction cDNA Library of Rat Circumvallate and Foliate Papiollae
- Molecular Cloning, Characterization, and Expression of Wheat Cystatins
- Salicylic Acid Carboxyl Methyltransferase Induced in Hairy Root Cultures of Atropa belladonna after Treatment with Exogeneously Added Salicylic Acid
- Importance of luxury flow for critically ill patients receiving a left ventricular assist system
- Structural Organization of the Gene Encoding Corn Cystatin
- Two Distinct Species of Corn Cystatin in Corn Kernels
- Organization and Primary Sequence of Multiple Genes Encoding Type II mRNA Species of Rice Prepro-glutelin(Biological Chemistry)
- A Mainstay of Functional Food Science in Japan-History, Present Status, and Future Outlook
- Invasive ductal adenocarcinoma of the pancreas may originate from the larger pancreatic duct : a study of 13 tumors less than 2cm in diameter
- Evidence of Introduction by Molecular Cloning of Artificial Inverted Sequence at the 5' Terminus of the Sense Strand of Rat Insulin-like Growth Factor-I cDNA(Biological Chemistry)
- Isolation and Characterization of a Novel Polysaccharide As a Possible Allergen Occurring in Wheat Flour
- Heterogeneous Nuclear Ribonucleoprotein K Interacts with and Is Proteolyzed by Calpain in vivo(Biochemistry & Molecular Biology)
- Purification and Characterization of an α-Amylase of Pichia burtonii Isolated from the Traditional Starter "Murcha" in Nepal
- Blood Substrates and Hormonal Responses to Increased Egg White Protein Intake Prior to a 12,000m Run in Heat
- The Tyrosine Kinase Activity of the Chicken Insulin Receptor Is Similar to That of the Human Insulin Receptor
- Nutritional Regulation of Insulin-like Growth Factor-I Receptor mRNA Levels in Growing Chickens
- Identification of Novel Fluorescent Pyrrolopyridinium Compound Formed from Maillard Reaction of 3-Deoxyglucosone and Butylamine
- Functional Expression and Enzymatic Properties of Two Sitophilus zeamais Cysteine Proteinases Showing Different Autolytic Processing Profiles In Vitro
- Purification and Properties of a Cysteine Proteinase Occurring in Dormant Wheat Seeds
- Characterization of a Gene Family Encoding Cysteine Proteinases of Sitophilus zeamais (Maize Weevil), and Analysis of the Protein Distribution in Various Tissues Including Alimentary Tract and Germ Cells
- Significance of the C-Terminal Domain of Erwinia uredovora Ice Nucleation-Active Protein(Ina U)
- Cloning and Sequencing of an Ice Nucleation Active Gene of Erwinia uredovora
- Large-scale Production and Purification of an Erwinia ananas Ice Nucleation Protein and Evaluation of Its Ice Nucleation Activity
- Establishment of Monoclonal Antibodies and Their Application to the Purification of Oryzacystatin(Biological Chemistry)
- Immunoassay of Oryzacystatin Occurring in Rice Seeds during Maturation and Germination(Biological Chemistry)
- DPJ-010 Techinical and Theoretical Evaluation of Off-pump Surgical Radiofrequency Ablation(DPJ02,Cardiovascular Surgery/CABG (IHD),Digital Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Combined surgery for ischemic cardiomyopathy : Report of a case
- PJ-397 Impact of Radiofrequency Maze Surgery on Postoperative Cardiac Function(Arrhythmia, therapy(20)(A),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Effect of Epidermal Growth Factor on Molar Tooth Morphogenesis in Serum-free and Serum-containing Media
- Immunohistochemical and Ultrastructural Studies of Experimental Epithelial Dysplasia Induced by Excisional Wounding and Trp-P-2 Application in Hamster Tongues
- Effects of MeIQx and EGF Applications on the Hamster Tongue after Excisional Wounding
- Gene Expression Analysis of the Anti-obesity Effect by Apple Polyphenols in Rats Fed a High Fat Diet or a Normal Diet
- I-11 Slide-Styler(Pneumatic massage apparatus) increases blood pressure and decreases pulse rate in normal subjects.(Proceedings of the 45th Meeting of Japan Society of Physiological Anthropology)
- Decrease of the Obese Gene Expression in Bovine Subcutaneous Adipose Tissue by Fasting
- NMR Structural Studies of a Rice Cysteine Proteinase Inhibitor, Oryzacystatin-I
- Crystallization and Preliminary X-Ray Diffraction Studies of a Rice Cysteine Proteinase Inhibitor, Oryzacystation-I
- Surgical Treatments for Infective Endocarditis Involving Valve Annulus
- Exposure to a high total dosage of glucocorticoids produces non-alcoholic steatohepatits
- Primary Structure of an Allergenic Peptide Occurring in the Chymotryptic Hydrolysate of Gluten
- Fabrication and Quality Evaluation of Hypoallergenic Wheat Products
- Controlled Enzymatic Treatment of Wheat Proteins for Production of Hypoallergenic Flour
- Dietary Protein as a Potent Regulator of the Hyaluronan Synthase Gene in Rat Skin(Food & Nutrition Science)
- Response of the Insulin-Like Growth Factor System to Vitamin A Depletion and Repletion in Rats
- Effects of Protein Deprivation on α1 (I) and α1 (III) Collagen and Its Degrading System in Rat Skin(Food & Nutrition Science)
- Isolation and Cultivation of a Novel Ice Nucleation-active Strain of Xanthomonas campestris
- Freeze Concentration of Some Foodstuffs Using Ice Nucleation-active Bacterial Cells Entrapped in Calcium Alginate Gel(Food & Nutrition)
- Pulmonary Paragonimiasis Misdiagnosed as Tuberculosis : With Special References on Paragonimiasis
- Construction of a Bioreactor with Immobilized Yeast Cells for Production of a Low-phenylalanine Peptide Mixture as a Phenylketonuria Foodstuff(Food & Nutrition)
- Enlarged-scale Production of a Low-phenylalanine Peptide Substance as a Foodstuff for Patients with Phenylketonuria
- Effects of Dexamethasone on the Production of Insulin-like Growth Factor-I and Insulin-like Growth Factor Binding Proteins in Primary Cultures of Rat Hepatocytes
- Transepithelial Transport of the Bioactive Tripeptide, Val-Pro-Pro, in Human Intestinal Caco-2 Cell Monolayers(Food & Nutrition Science)
- Chemical and Nutritional Properties of Hypoallergenic Wheat Flour
- Occurrence of Bound Salt in Freeze-concentrated Soy Sauce
- Inhibitory Effect of Arphamenine A on Intestinal Dipeptide Transport
- Physicochemical Study of Calcium-binding Properties of Chemical Substances as Inhibitors against Calcium Phosphate Insolubilization
- Inhibitory Activity of Oligo- and Poly-L-glutamic Acids against Calcium Phosphate Insolubilization and Calcium Binding with Special Relevance to Their Molecular Weight Dependence
- IS-21 Analysis of BRCA1 Gene Deletion in Japanese Ovarian Cancer by FISH
- Gene Cloning and Characterization of a Bacillus vietnamensis Metalloprotease
- Gibberellin-responsive Gene Expression Taking Place with Oryzains α and γ as Cysteine Proteinases of Rice Seeds
- Nutritional Effects of an Oligopeptide Mixture with a Very High Fischer Ratio on the Amino Acid Absorption and Cerebral Amine Metabolism in Rats Suffering from Galactosamine-induced Liver Injurry(Food & Nutrition)
- Enzymatic Modification of Zein to Produce a Non-bitter Peptide Fraction with a Very High Fischer Ratio for Patients with Hepatic Encephalopathy(Food & Nutrition)
- High-Pressure Sterilization of Ice Nucleation-active Bacterial Cells(Food & Nutrition)
- Heat-induced Gel Properties of Freeze-concentrated Egg White Produced Using Bacterial Ice Nuclei(Food & Nutrition)
- n-Alkylphenyldimethylammonium Salts as Inhibitors of the Ice Nucleating Activity of Erwinia ananas(Food & Nutrition)
- Modulating Effect of Sesamin, a Functional Lignan in Sesame Seeds, on the Transcription Levels of Lipid- and Alcohol-Metabolizing Enzymes in Rat Liver : A DNA Microarray Study
- Variance Analysis of a Clinical Pathway of Video-Assisted Single Lobectomy for Lung Cancer
- pH-Dependent Structural Change in Neoculin with Special Reference to Its Taste-Modifying Activity
- Improvement of Digestibility, Reduction in Allergenicity, and Induction of Oral Tolerance of Wheat Gliadin by Deamidation
- Up-Regulation of Genes Related to the Ubiquitin-Proteasome System in the Brown Adipose Tissue of 24-h-Fasted Rats
- Cell Culture and Motility Study on a Polymer Surface with a Nanometer-Scaled Stripe Structure
- Sardine Peptide with Angiotensin I-Converting Enzyme Inhibitory Activity Improves Glucose Tolerance in Stroke-Prone Spontaneously Hypertensive Rats
- Cathepsin D-Like Aspartic Proteinase Occurring in a Maize Weevil, Sitophilus zeamais, as a Candidate Digestive Enzyme
- Intraoperative Epicardial Echocardiography Locates the Origin of a Coronary-Pulmonary Artery Fistula
- Expression of the Stress-Related Genes for Glutathione S-Transferase and Ascorbate Peroxidase in the Most-Glycinin-Deficient Soybean Cultivar Tousan205 during Seed Maturation
- Application of an Aspergillus saitoi Protease Preparation to Soybean Curd to Modify Its Functional and Rheological Properties
- Polyphenols in Alcoholic Beverages Activating Constitutive Androstane Receptor CAR
- Human Bitter Taste Receptors hTAS2R8 and hTAS2R39 with Differential Functions to Recognize Bitter Peptides
- Antimicrobial Activity of Nutmeg against Escherichia coli O157
- PCR Method for Detecting Trace Amounts of Buckwheat (Fagopyrum spp.) in Food
- Distribution of Messenger RNAs of Insulin-like Growth Factor (IGF)-Binding Proteins-1 and -3 between Parenchymal and Nonparenchymal Cells in Rat Liver(Biological Chemistry)
- A New cDNA Clone Relating to Larger Molecular Species of Rat Insulin-like Growth Factor-I mRNA(Biological Chemistry)
- Non-Acidic Compounds Induce the Intense Sweet Taste of Neoculin, a Taste-Modifying Protein
- Disruption of the Availability of Amino Acids Induces a Rapid Reduction of Serine Phosphorylation of Insulin Receptor Substrate-1 in Vivo and in Vitro
- Gibberellin-induced Cysteine Proteinase Occurring in Germinating Rice Seeds and Its Specificity for Digesting Oxidized Insulin B-Chain(Food & Nutrition)
- Safety Evaluation of Hypoallergenic Wheat Flour by Using a DNA Microarray
- Diurnal Fluctuation in the Enzyme Activity and the Messenger RNA Level of Pineal Serotonin N-Acetyltransferase in Normal and Hereditary Microphthalmic Rats
- Response of the Insulin-Like Growth Factor System to Vitamin A Depletion and Repletion in Rats
- The solvent extraction of bivalent metal picrates by 15-crown-5, 18-crown-6, and dibenzo-18-crown-6.