Disruption of the Availability of Amino Acids Induces a Rapid Reduction of Serine Phosphorylation of Insulin Receptor Substrate-1 in Vivo and in Vitro
スポンサーリンク
概要
- 論文の詳細を見る
Insulin receptor substrate-1 (IRS-1) plays a pivotal role in insulin signal transduction. It has been shown that the amino acids modulate insulin signaling at the level of IRS-1. Here we show that an amino acid unbalanced diet causes a reduction in serine phosphorylation as well as an elevation in insulin-induced tyrosine phosphorylation of IRS-1 in rat muscle. In fibroblasts and myotube cells, the effect of amino acid deprivation on IRS-1 phosphorylation was evident only when cells were pretreated with reagents causing hyperphosphorylation of serines of IRS-1. But, the target kinases of these reagents were not inactivated by amino acid deprivation, suggesting that amino acid deprivation activates serine/threonine phosphatase(s) of IRS-1. The phosphatases regulated by mammalian target of rapamycin do not appear to participate in the dephosphorylation either. These results suggest that amino acid deprivation dephosphorylates IRS-1 through unidentified serine/threonine phosphatases and thereby potentiates insulin signaling.
- 社団法人 日本農芸化学会の論文
- 2005-05-23
著者
-
KATO Hisanori
Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo
-
Kato Hisanori
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
-
Toyoshima Yuka
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
-
OHNE Yoichiro
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The U
-
Ohne Yoichiro
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
関連論文
- Evidence of Introduction by Molecular Cloning of Artificial Inverted Sequence at the 5' Terminus of the Sense Strand of Rat Insulin-like Growth Factor-I cDNA(Biological Chemistry)
- The Tyrosine Kinase Activity of the Chicken Insulin Receptor Is Similar to That of the Human Insulin Receptor
- Nutritional Regulation of Insulin-like Growth Factor-I Receptor mRNA Levels in Growing Chickens
- Effect of Epidermal Growth Factor on Molar Tooth Morphogenesis in Serum-free and Serum-containing Media
- Immunohistochemical and Ultrastructural Studies of Experimental Epithelial Dysplasia Induced by Excisional Wounding and Trp-P-2 Application in Hamster Tongues
- Effects of MeIQx and EGF Applications on the Hamster Tongue after Excisional Wounding
- Gene Expression Analysis of the Anti-obesity Effect by Apple Polyphenols in Rats Fed a High Fat Diet or a Normal Diet
- Decrease of the Obese Gene Expression in Bovine Subcutaneous Adipose Tissue by Fasting
- Dietary Protein as a Potent Regulator of the Hyaluronan Synthase Gene in Rat Skin(Food & Nutrition Science)
- Response of the Insulin-Like Growth Factor System to Vitamin A Depletion and Repletion in Rats
- Effects of Protein Deprivation on α1 (I) and α1 (III) Collagen and Its Degrading System in Rat Skin(Food & Nutrition Science)
- Effects of Dexamethasone on the Production of Insulin-like Growth Factor-I and Insulin-like Growth Factor Binding Proteins in Primary Cultures of Rat Hepatocytes
- IS-21 Analysis of BRCA1 Gene Deletion in Japanese Ovarian Cancer by FISH
- Sardine Peptide with Angiotensin I-Converting Enzyme Inhibitory Activity Improves Glucose Tolerance in Stroke-Prone Spontaneously Hypertensive Rats
- PCR Method for Detecting Trace Amounts of Buckwheat (Fagopyrum spp.) in Food
- Distribution of Messenger RNAs of Insulin-like Growth Factor (IGF)-Binding Proteins-1 and -3 between Parenchymal and Nonparenchymal Cells in Rat Liver(Biological Chemistry)
- A New cDNA Clone Relating to Larger Molecular Species of Rat Insulin-like Growth Factor-I mRNA(Biological Chemistry)
- Disruption of the Availability of Amino Acids Induces a Rapid Reduction of Serine Phosphorylation of Insulin Receptor Substrate-1 in Vivo and in Vitro
- Safety Evaluation of Hypoallergenic Wheat Flour by Using a DNA Microarray
- Diurnal Fluctuation in the Enzyme Activity and the Messenger RNA Level of Pineal Serotonin N-Acetyltransferase in Normal and Hereditary Microphthalmic Rats
- Response of the Insulin-Like Growth Factor System to Vitamin A Depletion and Repletion in Rats
- The solvent extraction of bivalent metal picrates by 15-crown-5, 18-crown-6, and dibenzo-18-crown-6.